英文药名: Razadyne ER(Galantamine Extended Release Capsules)

中文药名: 加兰他敏缓释胶囊

生产厂家:

这个药通常也叫: Reminyl ER in Canada.

药品简介

美国食品和药物管理局近期通过了Razadyne ER可用于治疗轻至中度的早老性痴呆。Razadyne ER含有的速率控制膜成分能令药物在24小时内缓慢释放，同时含有的速效和缓释剂量只需每日服药一次，大大方便了患者用药及家人的照料。
早在2001年2月，美国食品和药物管理局就通过了名为REMINYL(R)的制剂，该药成分与Razadyne ER相同，每日服用两次。如今，有约200万早老性痴呆患者服用REMINYL(R)。2005年4月，REMINYL(R)改名为Razadyne ER，临床研究表明，每日只需服用一次的Razadyne ER在疗效、安全性和耐受性方面与REMINYL(R)相近。
一项有965名患者参与的临床试验发现，治疗6个月后，服用Razadyne ER患者的认识改善要较安慰剂组显著（根据“早老性痴呆评估量表”得分），此外，该组患者“早老性痴呆合作研究及日常生活能力”（ADCS-ADL）量表得分也明显优于安慰剂组。在该研究中，Razadyne ER的初始剂量为8mg/天共服用4周，随后增加至16mg/天共4周，之后根据患者的耐受情况及药物的安全性，酌情可将剂量增至24mg/天。约有80%的患者完成了该项研究。 恶心、呕吐、腹泻、食欲减退及体重减轻是Razadyne ER最常见的副作用，但这些副反应通常是轻微且暂时的。需要指出的是，并不是所有的患者都适用Razadyne ER。部分患者会出现心率的减慢，从而发生昏厥。有的患者在服用了非甾体类抗炎药后会引发诸如 胃溃疡等严重的胃肠道疾病。

RAZADYNE ER is the new name of REMINYL (galantamine HBr), Reminyl is already recognized for its safety and effectiveness in helping to preserve his or her cognitive skills and their ability to accomplish daily living activities. Reminyl comes in a once-daily formulation, RAZADYNE ER (galantamine HBr). RAZADYNE ER contains the active ingredient galantamine and is available in three dosage strengths, Razadyne ER 8mg, Razadyne ER 16mg, and Razadyne ER 24mg extended-release capsules. Razadyne ER helps those with mild to moderate AD delay the progression of symptoms including thinking and memory. RAZADYNE ER has the added benefit of being an extended-release capsule, taken only once a day.

The RAZADYNE ER capsules contain a rate-controlling membrane that allows the medication to be released gradually over a 24-hour period. This new formulation contains an immediate and extended release dose that allows for the convenience of once-daily dosing.

RAZADYNE ER is in a class of drugs called acetylcholinesterase inhibitors. Taken only once a day, the extended-release capsule is absorbed into the body consistently over a 24-hour period. Experts believe that RAZADYNE ER may block an enzyme that breaks down ACh in the brain, thereby making more ACh available.

Your doctor will be able to tell you whether it is safe to take RAZADYNE ER with other medications. Please inform your physician of any prescriptions, over- the-counter medication, vitamins, and herbal or dietary supplements that you may be taking.

Razadyne ER Side Effects:

In clinical trials, the most frequent adverse events with RAZADYNE ER were similar to those seen with RAZADYNE. The most common Razadyne ER side effects are nausea, vomiting, diarrhea, loss of appetite, and weight loss. Typically, these Razadyne ER side effects are mild and temporary. Razadyne ER may not be for everyone. Some people experience a slowed heart rate, which may lead to fainting. Serious stomach problems can occur in people taking medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) or those at risk for stomach ulcers.

REMINYL'S NAME HAS CHANGED TO RAZADYNE DUE TO PRESCRIBING ERRORS:

Rare but serious prescribing errors occurred due to confusion between REMINYL and AMARYL (glimepiride), a medication for Type 2 diabetes. To prevent further errors or confusion, Reminyl drugs name has changed REMINYL to RAZADYNE.

The most common adverse side effects with Razadyne ER were similar to those seen with Reminyl. The most common Razadyne ER side effects are nausea, vomiting, diarrhea, loss of appetite, and weight loss. Typically, these Razadyne ER side effects are mild and temporary. Razadyne ER may not be for everyone. Some people experience a slowed heart rate, which may lead to fainting. Serious stomach problems can occur in people taking medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) or those at risk for stomach ulcers.

Razadyne ER is now available from Canada. Razadyne ER is called Reminyl ER in Canada.
包装规格：
16mg *28 胶囊（Janssen 生产）
24mg *28 胶囊（Shire Pharma 生产）
8mg *28 胶囊（Shire Pharma 生产）