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美国食品和药物管理局近期通过了Razadyne ER可用于治疗轻至中度的早老性痴呆。Razadyne
ER含有的速率控制膜成分能令药物在24小时内缓慢释放，同时含有的速效和缓释剂量只需每日服药一次，大大方便了患者用药及家人的照料。
早在2001年2月，美国食品和药物管理局就通过了名为REMINYL(R)的制剂，该药成分与Razadyne ER相同，每日服用两次。如今，有约200万早老性痴呆患者服用REMINYL(R)。2005年4月，REMINYL(R)改名为Razadyne ER，临床研究表明，每日只需服用一次的Razadyne ER在疗效、安全性和耐受性方面与REMINYL(R)相近。
一项有965名患者参与的临床试验发现，治疗6个月后，服用Razadyne ER患者的认识改善要较安慰剂组显著（根据“早老性痴呆评估量表”得分），此外，该组患者“早老性痴呆合作研究及日常生活能力”（ADCS-ADL）量表得分也明显优于安慰剂组。在该研究中，Razadyne ER的初始剂量为8mg/天共服用4周，随后增加至16mg/天共4周，之后根据患者的耐受情况及药物的安全性，酌情可将剂量增至24mg/天。约有80%的患者完成了该项研究。
恶心、呕吐、腹泻、食欲减退及体重减轻是Razadyne ER最常见的副作用，但这些副反应通常是轻微且暂时的。需要指出的是，并不是所有的患者都适用Razadyne ER。部分患者会出现心率的减慢，从而发生昏厥。有的患者在服用了非甾体类抗炎药后会引发诸如胃溃疡等严重的胃肠道疾病。
氢溴酸加兰他敏 Galantamine Hydrobromide
作用与用途：本品为抗胆碱酯酶药，有较弱的抗胆碱酯酶作用，能透过血脑屏障，故对中枢神经系统作用比较强。使受阻碍的神经肌肉传导恢复，改善各种末梢神经肌肉障碍的麻痹状态。其治疗范围广，毒性较小，病人较易耐受。临床主要用于治疗脊髓灰质炎(小儿麻痹症)后遗症、肌肉萎缩及重症肌无力等。也可用于儿童脑型麻痹、外伤性感觉运动障碍、多发性神经炎及脊神经根炎等。
剂量与用法：口服，成人10mg/次，3次/日；小儿每日0.5mg～1mg/kg，分3次。皮下或肌注，成人2.5mg～10mg/次，1次/日。小儿每次0.05mg～0.1mg/kg，1次/日。对脊髓灰质炎后遗症可连续用药40～50日，一般20～40日为1个疗程，间隔30～45日后开始第二个疗程。经1～2个疗程后，病情仍未改善者，应停止使用。有效者可连续3个疗程。
副作用：
1 过量可发生流涎、眩晕、心动过缓及腹痛等不良反应。
2 癫痫、支气管哮喘、运动亢进、心绞痛、心动过缓者忌用。
Razadyne ER Description
This drug is used to treat mild to moderate confusion (dementia) related to Alzheimer's disease. It does not cure Alzheimer's disease, but it may improve memory, awareness, and the ability to perform daily functions. This medication works by restoring the balance of certain natural substances (neurotransmitters) in the brain.
Razadyne ER Directions
Take this medication by mouth with food, usually once daily in the morning with breakfast or as directed by your doctor. This medication may be taken on an empty stomach if necessary. Drink plenty of fluids with this medication unless instructed otherwise. To lower your risk of side effects, your dosage will be gradually increased to your target dose. Your dosage is based on your medical condition and response to therapy. Do not take more than the maximum recommended dose of 24 milligrams per day. Swallow the capsules whole. Do not crush or chew the capsules. Doing so can destroy the long action of the drug and may increase side effects. If you stop taking galantamine for several days, consult your doctor or pharmacist before restarting it. Your dosage should be reduced to lower the risk of side effects. Your dosage should then be increased gradually. Follow all your doctor's dosing instructions exactly. Use this medication regularly in order to get the most benefit from it. Do not stop taking it or increase the dosage unless your doctor instructs you to do so. It may take at least 4 weeks of continued use before the full benefit of this drug takes effect. Inform your doctor if your condition worsens.
Razadyne ER Cautions
Before taking galantamine, tell your doctor or pharmacist if you are allergic to it; or to daffodil plants; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe liver disease, severe kidney disease. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, kidney problems, stomach/intestinal problems (e.g., ulcers, bleeding), heart problems (e.g., sick sinus syndrome, bradycardia, AV block, arrhythmias), breathing/lung problems (e.g., severe asthma, COPD-chronic obstructive pulmonary disease), seizures, problems urinating (e.g., due to enlarged prostate). This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. Before having surgery, tell your doctor or dentist that you are taking this medication. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
Razadyne ER Side Effects
Nausea, vomiting, diarrhea, dizziness, loss of appetite, and weight loss may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: fainting, unusually slow heartbeat, difficult urination. Tell your doctor immediately if any of these rare but very serious side effects occur: seizures, black/bloody stools, vomit that looks bloody or like coffee grounds, severe stomach/abdominal pain, irregular heartbeat. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects.
Razadyne ER Active Ingredients
Galantamine
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注：以下产品不同规格和不同价格，购买时请以咨询为准！
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产地国家: 美国
原产地英文商品名:
RAZADYNE ER 24H CAPSULE 8mg/cap 30caps/bottle
原产地英文药品名:
GALANTAMINE HYDROBROMIDE
原产地英文化合物名称:
(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef]
[2]benzazepin-6-ol hydrobromide
中文参考商品译名:
RAZADYNE 24小时缓释胶囊 8毫克/胶囊 30胶囊/瓶
中文参考药品译名:
氢溴酸加兰他敏
生产厂家中文参考译名:
JANSSEN PHARMS
生产厂家英文名:
JANSSEN PHARMS
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产地国家: 美国
原产地英文商品名:
RAZADYNE ER 24H CAPSULE 16mg/cap 30caps/bottle
原产地英文药品名:
GALANTAMINE HYDROBROMIDE
原产地英文化合物名称:
(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef]
[2]benzazepin-6-ol hydrobromide
中文参考商品译名:
RAZADYNE 24小时缓释胶囊 16毫克/胶囊 30胶囊/瓶
中文参考药品译名:
氢溴酸加兰他敏
生产厂家中文参考译名:
JANSSEN PHARMS
生产厂家英文名:
JANSSEN PHARMS
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产地国家: 美国
原产地英文商品名:
RAZADYNE ER 24H CAPSULE 24mg/cap 30caps/bottle
原产地英文药品名:
GALANTAMINE HYDROBROMIDE
原产地英文化合物名称:
(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef]
[2]benzazepin-6-ol hydrobromide
中文参考商品译名:
RAZADYNE 24小时缓释胶囊 24毫克/胶囊 30胶囊/瓶
中文参考药品译名:
氢溴酸加兰他敏
生产厂家中文参考译名:
JANSSEN PHARMS
生产厂家英文名:
JANSSEN PHARMS
该药品相关信息网址1:
http://www.razadyneer.com/
该药品相关信息网址2:
http://www.rxlist.com/razadyne-er-drug.htm
该药品相关信息网址3:
http://www.drugs.com/cons/razadyne-er.html |
