美国食品药品管理局（FDA）宣布批准贝西沙星（besifloxacin，喹诺酮类抗菌素）0.6%眼用混悬液（商品名Besivance）用于治疗细菌性结膜炎（非病毒引起），这是一种传染性强的化脓性眼部刺激性结膜炎。

FDA抗感染及眼科药品办公室主任表示，细菌性结膜炎易感染各年龄层的人群，有效的药物治疗可以减少患者的患病时间并降低感染他人的几率，为医务人员和患者提供多样的治疗手段非常重要。

细菌性结膜炎多见于儿童，在其他年龄人群中也有发生。其症状包括眼睛发红、肿胀、眼睑高度水肿、刺痒、流泪并伴有白色或黄色分泌物。病情持续时间通常为7-14天。

在临床试验中，实验组康复的时间快于仅含防腐剂的对照组。Besivance对于一岁及以上的儿童也有疗效。

临床研究过程中不良反应的发生率不到3%，主要是眼睛发红、视力模糊、眼睛疼痛、刺痒及头痛。Besivance仅为滴眼液，不用于眼部注射。Besivance由博士伦公司（Bausch & Lomb）生产。
制造商：
博士伦制药

药理分类：
喹诺酮类

活性成分（补）：
Besifloxacin 0.6％;蛇夫座。的SUSP;含有苯扎氯。
指示（补）：
易患细菌性结膜炎。

药理作用：
Besifloxacin是具有活性的一克（+）和革兰品种喹诺酮类（ - ）的细菌。其他同类产品一样，它通过抑制细菌DNA旋转酶，这是复制，转录和DNA修复必要的细菌，和拓扑异构酶IV，这是为细胞分裂过程中染色体的DNA分割必要的。它有一个比氨基糖苷类，大环内酯类，β-内酰胺抗生素不同的作用模式，并可能因此对病原体提供能够抵抗这些其他抗生素的覆盖面。

该产品是治疗由过敏表示要对以下细菌引起的细菌性结膜炎的菌株：中华网棒形G组，棒状杆菌pseudodiphtheriticum，纹状体棒状杆菌，流感嗜血杆菌，莫拉lacunata，金黄色葡萄球菌，表皮葡萄球菌，金黄色葡萄球菌hominus，金黄色葡萄球菌lugdunensis，缓症链球菌群，口腔链球菌，肺炎链球菌，唾液链球菌。

与其他抗感染，对besifloxacin长时间使用可能导致非敏感微生物过度生长，计有真菌。如果超感染，就会停止使用，并制定替代疗法。跳绳剂量或不能完成整个疗程的治疗可能会降低，直接的治疗效果，增加的可能性，细菌会产生耐药性，不会被besifloxacin或将来在其他抗菌药物治疗。

Besivance是外用眼科只使用，不应该被注入结膜，也不应该被引入到眼睛前房直接。

临床试验：
一项随机，双盲，车辆控制的临床试验，在其中细菌性结膜炎的患者，眼科0.6％，与besifloxacin暂停三次，为期5天剂量。在这项试验中，besifloxacin被证明是优于临床决议（45对比33％，分别为％）的车辆。结果显示，微生物为besifloxacin致病病原体的车辆相比，显着根除率（91对比60％，分别为％）。

法律分类：
接收

成人和儿童：
<1年：不推荐。 ≥一年：1下降，受影响的似乎（意味着），每日3次为七天（4-12小时外）。使用前摇瓶一次。

警告/注意事项：
治疗期间，接触或删除，如果症状镜头。妊娠（Cat.C）。哺乳的母亲。

不良反应（补）：
结膜发红，视力模糊，眼睛疼痛/瘙痒/过敏，头痛，二重感染（中止和治疗）。

注释：
避免污染与眼睛，手指或其他来源的材料涂抹的一角。彻底洗净双手才能使用。反转封瓶和每次使用前摇一次。删除仍处于倒置位置与瓶盖。倾斜的后脑勺，并与瓶倒置，轻轻挤压瓶子灌输一到受影响的似乎（意味着）下降。

如何提供：
的SUSP，为5mL

最后更新：
7/16/2009

Besivance (Besifloxacin Ophthalmic Suspension)
The active substance in Besivance (besifloxacin ophthalmic suspension) – besifloxacin – is a common bacterial fighter that both prevents and cures particular diseases caused by bacteria. The substance is used in a wide variety of medicines indicated for various diseases. The ophthalmic version is strictly directed towards the eye infections.

The infections of the eye occur from multiple reasons. The most common ones are the dust and the patients’ lack of care by rubbing their eyes without washing their hands before. They may also be caused by other medicines, as secondary effects. For all these reasons, Besivance (besifloxacin ophthalmic suspension) is probably the most appropriate solution. It has been approved by the FDA in 2009 and may be released with a medical prescription only, especially since there haven’t been any advanced tests performed with this medicine.

Administration
Besivance (besifloxacin ophthalmic suspension) is administered by drops in your eyes. The administration procedures are identical to those for other similar medicines. You need to tilt your head back and have someone drop it in your eye. You may ask a friend or even better, a family member, especially due to the frequency of administration. The first dose will probably be given by your doctor, to check out for any adverse reactions and to show you precisely how to do it.

The dose is one drop in the affected eye. You need four drops a day during your awake time, with at least 4 hours between two consecutive doses. The treatment should go on for about a week. It may be prolonged if the infection is severe.

Keep the Besivance (besifloxacin ophthalmic suspension) bottle in a safe place, away from children, moisture and direct sunlight, at the room temperature.

If you miss a dose, delay your treatment with a few hours then. If it is almost time for the next one, then forget about it. Overdoses are less likely to occur too. You will have to call a doctor if you get one, but there aren’t any major or life threatening effects to be worried about.

Contraindications
Besivance (besifloxacin ophthalmic suspension) is not indicated in the sufferers who might present an allergy to at least one component. Other than that, you should only use it for your affected eye, not for the healthy one too. If you accidentally ingest some of this medication, drink water to dilute the substance.

Don’t use it with contact lenses either, as it may harm both the lenses and your eyes.

Side effects
There aren’t any major adverse reactions to the Besivance (besifloxacin ophthalmic suspension) treatment. They normally include mild headaches and a small discomfort.