pedtabs，乳酸杆菌和维生素B群

组成
每个套件包含
兰索拉唑胶囊
每个胶囊含有：
兰索拉唑30毫克（肠溶颗粒）
替硝唑片
每个薄膜包衣片剂包含....
替硝唑的IP 500毫克
克拉霉素片
每个薄膜包衣片剂包含....
克拉霉素的USP 250毫克

描述
幽门螺旋杆菌可能是与全球约50％的患病率最常见的细菌感染。幽门螺旋杆菌被牵连在人类胃炎和胃溃疡的病因。

包括如质子泵抑制剂兰索拉唑加替硝唑和克拉霉素新三联疗法为根除幽门螺旋杆菌为短，更简单和有效的药物治疗。
兰索拉唑和磺胺类药物代谢物的范围从0.6 mg/L-2.5毫克/升的中等收入国家这是比奥美拉唑更有力的四倍。
替硝唑，5 - 硝基咪唑是一种对幽门螺旋杆菌的抗菌剂和发挥快速杀菌作用。
克拉霉素具有良好的体外活性（90值0.03微克/升），这使得它适合纳入到方案根除幽门螺旋杆菌感染对幽门螺旋杆菌的MIC。

主治
PyloKit表示H.在活跃的慢性胃炎，十二指肠溃疡和胃溃疡的幽门螺旋杆菌根除。

剂量和给药方法
一个PyloKit包中包含两个胶囊（30毫克），兰索拉唑，替硝唑片（500毫克）和两克拉霉素片（250毫克）。一包是一天的治疗。从这个特别设计的包，兰索拉唑胶囊，替硝唑片剂和克拉霉素片是在上午和应采取同样在晚上。治疗建议的期限为七天。
肾脏和肝脏损害
应谨慎行事，而管理Pylokit与肾功能损害和肝脏疾病。

禁忌
兰索拉唑或替硝唑或克拉霉素过敏。

警告和注意事项
•克拉不应使用在怀孕的妇女，在没有合适的替代疗法是临床情况除外。如果怀孕的发生，同时服用克拉霉素，病人应告知潜在危害的foetus.Clarithromycin已经证明在猴子，大鼠，小鼠，兔和妊娠结局安道尔胚胎，胎儿发育有不良影响的剂量血浆2 17倍人最大推荐剂量治疗人类所取得的水平。
•伪膜性肠炎发生，几乎所有的抗菌剂，包括克拉霉素和可能的严重程度从轻微到危及生命。因此，重要的是要考虑这个诊断患者与腹泻的管理PyloKit后提出。

药物相互作用
茶碱：谁是病人接受茶碱使用克拉霉素可与血清中茶碱浓度的增加有关。
卡马西平：已被证明同时服用单剂量克拉霉素和卡马西平导致卡马西平的血药浓度增加。
华法林：克拉霉素的患者在接受warfarin的使用可能会导致在华法林时程增强效应。在这些患者中，凝血酶原时间应经常监测。
可能可以与克拉霉素同时给予地高辛：地高辛的影响。
特非那定：已被证明同时服用单剂量克拉霉素与特非那定，特非那定的血药浓度增加导致。
克拉不应接受特非那定治疗的患者，有现成的心脏异常（心律失常，心动过缓，QT间期延长，缺血性心脏疾病，充血性心脏衰竭）或电解质紊乱。
麦角麦角中毒的理论可能性contraindicates克拉霉素与麦角衍生物同时使用。
环孢菌​​素：克拉增加环孢素血药浓度，因此后者的剂量可能会减少，以避免肾毒性。
克拉霉素的细胞色素P450系统代谢的药物同时服用的患者使用这些药物的血清水平升高可能与。
酮康唑，氨苄西林酯，铁盐：兰索拉唑引起深刻和持久的抑制胃酸分泌的。因此，这是可能的，兰索拉唑，可能会干扰这些药物的吸收。
酒精：酒精的摄入量，在这种疗法可诱发的antabuse的效果，因此应避免。
双硫仑：同时服用可导致精神错乱和混乱。

怀孕
兰索拉唑，替硝唑，克拉霉素：有没有很好的控制，兰索拉唑或替硝唑或克拉霉素在孕妇的研究。克拉霉素是不是表明，在怀孕期间，因此这个组合是不是表示怀孕。

哺乳
它不知道是否兰索拉唑或替硝唑或克拉霉素母乳中排出。管理哺乳妇女时，应谨慎行事。

儿科使用
儿科人口PyloKit有效性和安全尚未确定。

副作用
的PyloKit药物的耐受性良好。副作用包括恶心，呕吐，腹泻和腹痛。其他罕见的副作用包括头痛，皮疹，金属味（味觉出现变化），很少舌炎，口腔炎，荨麻疹，火山喷发和中度白细胞减少症。

过量
在过量的情况下，停止用药，对症治疗，需要研究所的支持措施。

存储
存放在阴凉干燥的地方

PyloKit
Pedtabs, Lactic acid bacilli and vitamin B –complex

COMPOSITION
Each kit contains
Two capsules of Lansoprazole
Each capsule contains:
Lansoprazole 30 mg (as enteric coated granules)
Two tablets of Tinidazole
Each film-coated tablet contains ....
Tinidazole IP 500 mg
Two tablets of Clarithromycin
Each film-coated tablet contains ....
Clarithromycin USP 250 mg

Description
Helicobacter pylori is probably the most common bacterial infection with a worldwide prevalence of approximately 50%. Helicobacter pylori is implicated in the etiology of gastritis and peptic ulcers in humans.

Newer triple therapies including proton pump inhibitor such as lansoprazole plus tinidazole and clarithromycin serve as shorter, simpler and effective drug regimen for the eradication of H. pylori.
The MICs of lansoprazole and its sulfonamide metabolite ranges from 0.6 mg/L-2.5 mg/L. It is four times more potent than omeprazole.
Tinidazole, a 5-nitroimidazole is an antimicrobial agent against H. pylori and exerts rapid bactericidal action.
Clarithromycin has good in vitro activity (MIC 90 value-0.03 µg/L) against H. pylori which make it suitable for incorporation into regimen for the eradication of H. pylori infection.

Indications
PyloKit is indicated for the eradication of H. pylori in active chronic gastritis, duodenal and gastric ulcers.

Dosage and Administration
One PyloKit pack contains two capsules of lansoprazole (30 mg), two tablets of tinidazole (500 mg) and two tablets of clarithromycin (250 mg). One pack is for one day treatment. From this specially designed pack, one capsule of lansoprazole, one tablet of tinidazole and one tablet of clarithromycin is to be taken in the morning and similarly one each in the evening. The duration of therapy recommended is for seven days.
Renal And Hepatic impairment
Caution should be exercised while administering Pylokit with renal impairment and hepatic disease.

Contraindications
Hypersensitivity to lansoprazole or tinidazole or clarithromycin.

Warnings and Precautions
• Clarithromycin should not be used in pregnant women except in clinical circumstances where no alternative therapy is appropriate. If pregnancy occurs while taking clarithromycin,the patient should be apprised of the potential hazards to the foetus.Clarithromycin has demonstrated adverse effects of pregnancy outcome andor embryo-foetal development in monkeys,rats,mice,and rabbits at doses that produced plasma levels 2 to 17 times the serum levels achieved in humans treated at the maximum recommended human doses.
• Pseudomembranous colitis has occurred with nearly all antibacterial agents including clarithromycin and may range in severity from mild to life-threatening. Therefore it is important to consider this diagnosis in patients who present with diarrhoea subsequent to the administration of PyloKit .

Drug Interactions
Theophylline: Clarithromycin use in patients who are receiving theophylline may be associated with an increase in serum theophylline concentrations.
Carbamazepine: Concomitant administration of single doses of clarithromycin and carbamazepine has been shown to result in increased plasma concentrations of carbamazepine.
Warfarin: The use of clarithromycin in patients receiving warfarin may result in potentiation of the effects of warfarin. Prothrombin time should be frequently monitored in these patients.
Digoxin: The effects of digoxin may be potentiated with concomitant administration of clarithromycin.
Terfenadine: Concomitant administration of single dose of clarithromycin and terfenadine have been shown to result in increased plasma concentrations of terfenadine.
Clarithromycin should not be given to patients receiving terfenadine therapy who have pre-existing cardiac abnormalities (arrhythmia, bradycardia, QT interval prolongation, ischemic heart disease, congestive heart failure) or electrolyte disturbances.
Ergot: The theoretical possibility of ergotism contraindicates the concurrent use of clarithromycin with ergot derivatives.
Cyclosporin: Clarithromycin increases the serum concentration of cyclosporin hence the dosage of latter may be reduced to avoid renal toxicity.
The use of clarithromycin in patients concurrently taking drugs metabolised by the cytochrome P450 system may be associated with elevations in serum levels of these drugs.
Ketoconazole, Ampicillin esters, Iron salts: Lansoprazole causes a profound and long lasting inhibition of gastric acid secretion. Therefore it is possible that lansoprazole may interfere with the absorption of these drugs.
Alcohol: Intake of alcohol during this therapy can precipitate an antabuse effect and hence should be avoided.
Disulfiram: Concomitant administration can cause delirium and confusion.

Pregnancy
Lansoprazole, Tinidazole, Clarithromycin: There are no well controlled studies of lansoprazole or tinidazole or clarithromycin in pregnant women. Clarithromycin is not indicated during pregnancy , Hence this combination is not indicated in pregnancy.

Lactation
It is not known whether lansoprazole or tinidazole or clarithromycin is excreted in breast milk. Caution should be exercised when administering to a nursing woman.

Paediatric Use
Safety and effectiveness of PyloKit in pediatric population has not been established.

Side Effects
The drugs of the PyloKit are well tolerated. Side effects include nausea, vomiting, diarrhoea and abdominal pain. Other rare side effects include headache, skin rash, metallic taste (change in taste), rarely glossitis, stomatitis, urticaria, eruptions and moderate leucopenia.

Overdosage
In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required.

Storage
Store in a cool dry place

Presentation
PyloKit ---------------------Box of 1 kit