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沐舒坦缓释胶囊MUCOSOLVAN（AMBROXOL）

2012-11-28 22:54:30 作者：新特药房来源：互联网浏览次数：1564 文字大小：【大】【中】【小】

简介： 【药物名称】Ambroxol hydrochloride, NA-872, Mucosolvan, Mucosolvan-L, Mucosal-L, Ponophen【化学名称】trans-4-(2-Amino-3,5-dibromobenzylamino)cyclohexanol hydrochloride【CAS登记号】23828-9 ...

关键字：沐舒坦缓释胶囊氨溴索术后肺部并发症祛痰

【药物名称】Ambroxol hydrochloride, NA-872, Mucosolvan, Mucosolvan-L, Mucosal-L, Ponophen
【化学名称】trans-4-(2-Amino-3,5-dibromobenzylamino)cyclohexanol hydrochloride
【CAS登记号】23828-92-4, 18683-91-5 (free base)
【结构式】
【分子式】C13-H18-Br2-N2-O.Cl-H
【分子量】414.5671
【原研厂家】NicOx (Originator), Boehringer Ingelheim (Not Determined), Teijin (Not Determined)
【作用类别】Mucolytics, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders
【研发状态】Launched

部分中文沐舒坦处方资料（仅供参考）

名　称：沐舒坦 Mucosolvan

制造商：德国勃林格殷格翰大药厂 Boehringer Ingelheim Beijing Sixth Pharm

简介
沐舒坦 Mucosolvan
呼吸道清道夫-全新针剂型
廓清效果深入肺泡

成分
一安瓿2ml含15mg
lAmbroxol HCI盐酸氨溴（又称盐酸溴环已胺醇）

特性
沐舒坦的活性成分—盐酸氨溴（lAmbroxol HCI）在临床试验中证明,可调节浆液与粘液的分泌,促进肺部表面活物质的合成,加强纤毛摆动（增加粘液纤毛运输系统的清除能力）,使咯痰变得容易。

适应证
适用于伴痰液分泌不正常及排痰功能不良的急性、慢性呼吸道疾病。例如慢性支气管炎急性加重、喘息型支气管炎、支气管扩张及气管哮喘的祛痰治疗。
术后肺部并发症的预防性治疗。
早产儿及新生儿婴儿呼吸窘迫综合症（IRDS）的治疗。

禁忌证
已知对盐酸氨溴索或其他配方成分高反应性者不宜使用。

副作用
沐舒坦通常能很好耐受，曾有轻度的胃肠道副作用报道，主要为胃部灼热、消化不良和偶尔出现恶心、呕吐，过敏反应极少出现。

药物相互作用
沐舒坦与抗生素同时应用（阿莫西林、头孢呋新、红霉素、强力霉素）可导致抗生素在肺组织的浓度升高，与其它药物合所致临床相关不良影响未见报道。

剂量和用法
安瓿（15mg/2ml）

预防治疗
成人：每天2-3次，每次1安瓿，慢速静脉注射，严重病例要以增至每次2安瓿。
6岁以上儿童：每天2-3次，每次1安瓿
2-6岁儿童：每天3次，每次1/2安瓿
2岁以下儿童：每天2次，每次1/2安瓿
均为慢速静脉注射
婴儿呼吸窘迫综合症（IRDS）的治疗：
每日用药总重以婴儿体重计算30mg/kg，分4次给药，应使用注射泵给药。静脉输注时间至少5分钟。
本注射液亦可与葡萄糖、果糖、盐水或林格氏液混合静脉点滴使用。
沐舒坦（pH5.0）不能与pH大于6.3的其它溶液混合，因为pH值增加会导致产生沐舒坦游离碱沉淀。

Mucosolvan (Behringer Ingelheim)
DESCRIPTION
The active agent, Ambroxol is a proven, reliable and effective expectorant. It enables sticky phlegm to be removed from the respiratory system faster and more easily by enhancing the bronchial secretions that loosen congested phlegm. Ambroxol also releases and strengthens the cilia (tiny striking hairs inside the windpipe and bronchial tubes), which can then expel the abnormal phlegm with their conveyor-belt like action.
Ambroxol increases the body's production of surfactant, a substance that promotes the clearance mechanism for elimination of germs or other pathogens, which helps to prevent and overcome infection in the bronchi.
Ambroxol was first introduced in the form of Mucosolvan� in 1978 and has proven to be a reliable, trusted expectorant for the treatment of productive cough. Mucosolvan� is one of the leading therapies for cough and is available in many countries around the world.
MODE OF ACTION
Ambroxol is the active agent in Mucosolvan�. It makes phlegm in the airways thinner and less sticky. It does this by increasing the body's natural production of surfactant. This contributes to a secretomotoric effect: it helps the cilia - tiny hairs that line the respiratory tract - to transport the phlegm out of the lungs. Here is a step-by-step description of how Ambroxol works:
1. Ambroxol is quickly metabolised by the body. It goes straight to work at the mucus-secreting cells, where it changes the mucus so it becomes less viscous. This thinner, more liquid mucus helps lift the heavy, sticky phlegm off the walls of the airways.
2. Ambroxol frees and activates the cilia. Thanks to the effect of the thinner mucus, the cilia are no longer clogged by the thick, sticky phlegm. They are free to move again and help to push the phlegm up and out of the respiratory tract. Furthermore, Ambroxol enhances the movement of the cilia so they transport phlegm out of the airways more quickly.
3. Ambroxol is not a cough suppressant. It does not interfere with the body's natural cough response. This is important, because coughing is still needed to eject the excess phlegm from the airways. Ambroxol makes it easier to get the phlegm moving again.
HOW SUPPLIED
Mucosolvan Productive Cough Syrup
Mucosolvan Productive Cough Syrup for Children
Mucosolvan Productive Cough Cough Pastilles
Mucosolvan Productive Cough One-A-Day Capsules
Mucosolvan Productive Cough Effervescent Tablets
Mucosolvan Productive Cough Tablets
Marketed by:
Behringer Ingelheim
Mucosolvan is a registered trademark of Behringer Ingelheim
附件：

20122621442534.PDF

20122621442017.PDF
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产地国家: 德国
原产地英文商品名:
MUCOSOLVAN PROLONGED RELEASE RETARDKAPS 75mg/cap 50caps/box
原产地英文药品名:
AMBROXOL
中文参考商品译名:
沐舒坦RETARDKAPS缓释胶囊 75毫克/胶囊 50胶囊/盒
中文参考药品译名:
氨溴索
生产厂家中文参考译名:
勃林格殷格翰 & Co. KG Vertriebslinie Thomae
生产厂家英文名:
Boehringer Ingelheim Pharma GmbH & Co. KG Vertriebslinie Thomae
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产地国家: 德国
原产地英文商品名:
MUCOSOLVAN PROLONGED RELEASE RETARDKAPS 75mg/cap 20caps/box
原产地英文药品名:
AMBROXOL
中文参考商品译名:
沐舒坦RETARDKAPS缓释胶囊 75毫克/胶囊 20胶囊/盒
中文参考药品译名:
氨溴索
生产厂家中文参考译名:
勃林格殷格翰 & Co. KG Vertriebslinie Thomae
生产厂家英文名:
Boehringer Ingelheim Pharma GmbH & Co. KG Vertriebslinie Thomae
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产地国家: 德国
原产地英文商品名:
MUCOSOLVAN PROLONGED RELEASE RETARDKAPS 75mg/cap 10caps/box
原产地英文药品名:
AMBROXOL
中文参考商品译名:
沐舒坦RETARDKAPS缓释胶囊 75毫克/胶囊 10胶囊/盒
中文参考药品译名:
氨溴索
生产厂家中文参考译名:
勃林格殷格翰 & Co. KG Vertriebslinie Thomae
生产厂家英文名:
Boehringer Ingelheim Pharma GmbH & Co. KG Vertriebslinie Thomae