Flomax第二代产品在英国问世
Astellas制药公司称，其良性前列腺肥大症治疗药物Flomax(tamsulosin)的第二代产品已经在英国问世，该药产品名为Flomaxtra XL，每日用药一次。
Flomax XL采用了Astellas公司自身的口服控制吸收系统相关技术，它可以在24小时之内更加恒定和连贯地释放药物，血药浓度峰值更低，药物动力研究结果更为理想。Astellas公司希望该药能为患者和保健专职人员提供更好的治疗方式，特别是在夜尿症控制方面。
相关人士称，多年来，Flomax一直是治疗良性前列腺肥大症的主要治疗药物，而Flomaxtra XL效果会更好。除了在治疗夜尿症方面取得进步之外，与现有的其他药物相比，Flomaxtra XL在24小时内药物的平缓释放可以减少其副作用。相关数据表明，与常规的坦索罗辛（tamsulosin）相比，它对心血管造成的副作用更小。
Flomaxtra XL (tamsulosin)
Main use：Enlarged prostate gland
Active ingredient：Tamsulosin hydrochloride
Manufacturer：Astellas Pharma Limited
How does it work?
Flomaxtra XL tablets contain the active ingredient tamsulosin hydrochloride, which is a type of medicine called an alpha blocker.
It works by blocking alpha receptors that are found in the muscle in the prostate gland.
The prostate gland, which is found only in men, lies at the top of the tube connecting the bladder to the outside (urethra). The prostate gland often enlarges with advancing age (benign prostatic hyperplasia), pressing on the urethra and obstructing the flow of urine from the bladder. This can cause various urinary symptoms, such as difficulty passing urine.
Tamsulosin blocks alpha receptors in the muscle of the prostate gland, which causes the muscle in the prostate to relax. This allows urine to flow freely past the prostate and relieves the urinary symptoms.
Flomaxtra XL are 'prolonged-release' tablets. They are designed to release the tamsulosin gradually as they pass through the stomach and intestine, so that a steady amount of medicine is absorbed into the bloodstream throughout the day. The tablets must be swallowed whole and must not be chewed, broken or crushed, as this would stop
the prolonged-release action from working.
What is it used for?
Enlarged prostate gland (benign prostatic hyperplasia).
Warning!
This medicine may cause dizziness, light-headedness and on rare occasions fainting. Take care when moving from a lying down or sitting position to sitting or standing, particularly if you wake up in the night, until you know how this medicine affects you.
If you feel dizzy or light-headed at any time during treatment, sit or lie down until the symptoms pass.
This medicine may cause drowsiness, dizziness or blurred vision and so may affect your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.
This medicine does not cause prostate cancer, but prostate cancer can be another cause of an enlarged prostate gland. For this reason, tests for prostate cancer should be carried out before you start treatment with this medicine, and at regular intervals thereafter.
One test that can be carried out is a digital rectal examination(DRE), to check if the prostate gland is enlarged. The other is to measure the level of prostate specific antigen (PSA) in the blood.
An increase in the PSA levels may mean that the prostate gland is enlarged.
If you are scheduled to have eye surgery for cataracts it is important to let your eye specialist know if you are or have been taking this medicine. This is because tamsulosin can make your pupil dilate poorly and the iris (the coloured circular part of the eye)become floppy during the procedure. The specialist needs to know if you have been taking this medicine so they can take appropriate precautions with the medicines and techniques they use during the surgery. You may be asked to stop taking this medicine for a period of time before cataract surgery. Check with your doctor.
Use with caution in
Severely decreased kidney function.
Not to be used in
History of drops in blood pressure when moving from a sitting or lying position to standing, which causes dizziness (postural hypotension).
Severely decreased liver function.
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Label warnings
This medication is to be swallowed whole, not chewed.
Side effects
Medicines and their possible side effects can affect individual people in different ways.
The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Common (affect between 1 in 10 and 1 in 100 people)
Dizziness.
Uncommon (affect between 1 in 100 and 1 in 1000 people)
Headache.
Awareness of your heartbeat (palpitations).
A drop in blood pressure that occurs when going from lying down to sitting or standing, which results in dizziness and lightheadedness (postural hypotension).
Inflammation of the lining of the nose (rhinitis) causing a blocked or runny nose.
Disturbances of the gut such as diarrhoea, constipation, nausea or vomiting.
Skin reactions such as rash and itch.
Abnormal ejaculation.
Weakness or loss of strength (asthenia).
Rare (affect between 1 in 1000 and 1 in 10,000 people)
Fainting (syncope).
Swelling due to fluid retention (oedema).
Very rare (affect less than 1 in 10,000 people)Persistent painful erection of the penis (priapism).
Unknown frequency
Drowsiness.
Blurred vision.
Dry mouth.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.
Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
If this medicine is taken with other medicines that can reduce blood pressure, this effect may be enhanced, with an increased chance of dizziness or fainting. Other medicines that may reduce blood pressure include the following:
anaesthetics
medicines for high blood pressure
other alpha blockers
phosphodiesterase type 5 inhibitors for impotence, eg sildenafil, vardenafil, tadalafil.
Other medicines containing the same active ingredient
Flomax relief MR
Bazetham MR
Stronazon MR 
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产地国家: 英国
原产地英文商品名:
FLOMAXTRA XL 400mcg/tab 30tabs/box
原产地英文药品名:
TAMSULOSIN HYDROCHLORIDE
中文参考商品译名:
FLOMAXTRA XL 400微克/片 30片/盒
中文参考药品译名:
盐酸坦索罗辛
生产厂家中文参考译名:
安斯泰来
生产厂家英文名:
Astellas

该药品相关信息网址1:
http://www.epgonline.org/drugs/flomaxtra/
该药品相关信息网址2:
http://www.netdoctor.co.uk/seniors-health/medicines/flomaxtra-xl.html