英文药名: LENTINAN（lentinan injection） 中文药名: 香菇多糖注射液 生产厂家: 味之素制药 レンチナン静注用1mg「味の素」 治疗类别名称 抗肿瘤药 商標名 LENTINAN 一般名 レンチナン（lentinan） 分子式 （C6H10O5）N 结构式 性状 在灰白色粉末呈淡黄白色，有异味或稍微没有气味，没有味道。 （95），或几乎不溶于丙酮，水，甲醇，乙醇，溶解在0.5mol/ L氢氧化钠溶液，它是吸湿的。 组成 活性组分（1瓶） 香菇：1MG 剂型 冻干制剂，注射剂所使用的溶解 添加剂（1瓶） D-甘露醇：100mg产品 葡聚糖40:2毫克 性状 该药物是一种白色固体多孔。 适应病症 结合长期生存在胃癌复发或不能手术的患者口服替加氟管理。 用法与用量 成人；在与口服给药组合替加氟600mg的/天（400毫克/米2/天），每周2毫克（每周两次或2mg的每周一次1mg的），为香菇多糖静脉注射或静脉滴注。 <注射法的制备> 1小瓶天办公室注射用水，日本药典生理盐水，或一天台5％或20％的葡萄糖注射液2ml-5mL的加入并强烈振摇充分溶解。 包装规格 静脉注射 1mg“味之素”10瓶 生产和销售 味之素制药有限公司 1mg “沢井”10瓶 生产和销售 泽井药业有限公司 注：以上中文资料仅供参考，使用以原处方为准： http://www.info.pmda.go.jp/go/pack/4299401D1083_2_04/ On April 16, Ajinomoto Pharmaceutical and Taiho Pharmaceutical Co., Ltd. approved the manufacture and marketing approval of Ajinomoto Pharmaceutical, and with regard to anticancer agent "lentinan IV for intravenous injection 1 mg" Ajinomoto "(generic name: lentinan), which was outsourced to Taiho Pharmaceutical, From 1 July announced that Ajinomoto had agreed to sell. This sales company change is due to the expiration of the contract term. It is a polymeric glucan extracted by hot water extraction from shiitake mushrooms, and has an action to enhance immune function. Since its launch in 1986, "efficacy effect" is defined as "prolonging survival time by combined use with tegafur oral administration in inoperable or recurrent gastric cancer patients". Lentinan Lentinan This product is extracted from the mushroom (Lentinus edodes) fruiting body, purified polysaccharide. The basic structure is a polymer dextran with two β (1 → 3) -based side chains on each of the five β-(1 → 3) -based glucose chains. Traits It is a white porous solid and soluble in water. Pharmacology and application Experimental study in a variety of animal tumors can reduce the tumor and extend the survival time of animals. The mechanism of action is not to directly cytotoxic effect on tumor cells, but by activating the host's disease prevention mechanism, including cytotoxicity of killer T cells and activated macrophages, natural killer cells (NK) and antibody-dependent macrophages Effect (ADMC). Intravenous injection of lentinan after the rapid decline in blood concentration, later slowed down. Blood in the clear two-compartment model. 5 minutes after administration of the organs are distributed, followed by liver, spleen, lung, kidney. Most of the initial administration of urine from the discharge, after a long time from the urine and feces slowly discharged. Clinical indications: for radiotherapy adjuvant drugs, mainly for gastric cancer, lung cancer and breast cancer. Japan's Taguchi iron and other drugs and FT-207 combined with the treatment of advanced gastric cancer, can enhance the latter's anti-tumor effect, and extend the survival time of patients. We have this product and carboplatin, VP-16 combined with the treatment of small cell lung cancer, 3-year survival rate has increased, domestic for colorectal cancer, gastric cancer, breast cancer to a certain extent, improve the patient's cellular immune function, improve the chemotherapy effect. usage Each time 1mg, intravenous injection, 2 times a week, or 2mg each time, once a week. Diluted intravenously with normal saline or 5% glucose. note Generally 6.8% of patients have a transient rash or flushing, nausea, dizziness, chest compression, sweating and so on. preparation Lentinan injection: 1mg per bottle. Storage method Store at room temperature.