英文药名：5-FU Injection（Fluorouracil）

中文药名：氟尿嘧啶 5-FU注射液

生产厂家：协和发酵麒麟

5-FU注250mg／5-FU注1000mg

类别名称
抗肿瘤药
一般名
フルオロウラシル　Fluorouracil
化学名
5-Fluorouracil
略名
5-FU
分子式
C4H3FN2O2=130.08
化学構造式

性状
白色结晶或结晶性粉末，无臭味。
可溶性
N，易溶于N-二甲基甲，微溶于水，乙醇（95）中微溶，并在乙醚中几乎不溶。
熔点
约282℃（分解）
分配系数
logP'OCT=-1.00
（测量方法：摇瓶法正辛醇/pH7.4缓冲溶液）
适应病症
下列疾病的主观和TaSatoshi症状缓解
胃癌，肝癌，大肠癌，乳癌，胰脏癌，子宫颈癌，子宫内膜癌，卵巢癌
下列疾病，在与其他抗肿瘤剂或放射组合必要。
食道癌，肺癌，头颈部肿瘤
组合疗法与其他抗肿瘤剂为以下恶性肿瘤
头颈部肿瘤
用法用量
1. 单独使用
(1) 通常，注射或静脉滴注静脉内每天一次5-15毫克/公斤的第一每天连续5天的成人。注射或静脉滴注静滴，每日一次此后5-7.5mg/kg，每一天。
(2) 通常，注射或静脉滴注静脉内一次5 1天每天15毫克/公斤，隔日成人。
(3) 通常，注射或静脉滴注每天日常5毫克，每天静脉内一次/ kg的10-20天的成人。
(4) 通常，注射或静脉滴注静脉内每天一次10-20毫克/每星期公斤的成年人。
此外，通常在动脉根据需要，用于适当地注射每日为5mg/kg成年人。
应当指出的是，增加或减少取决于患者的年龄和症状。
2.与其它抗肿瘤剂或放射使用
通常，成人每天5-10毫克/公斤，与其它抗肿瘤剂或放射组合，根据第一种方法，或断续地每周使用一次或两次。
3.在组合疗法与其他抗肿瘤剂用于头部和颈部癌症的情况下
在联合疗法中与其他抗肿瘤剂，通常为成人1天为氟尿嘧啶1000毫克/米2（体表面积），并在每天4-5天连续输注。在反复给药的情况下在至少三个周的间隔给药。在仅此药物的情况下是类似的，当在组合给药。
应当指出的是，年龄，要正确减肥由于患者的状况。
4. Rebohorinato氟尿嘧啶联合静脉滴注治疗大肠癌
(1) 成人：一次100毫克体表面积/平方米以上一个周期2小时注射一次输注静脉作为Rebohorinato的。静脉注射400毫克/平方米（体表面积），为氟尿嘧啶，进一步为600mg/ m2的过（体表面积），22小时的连续输注作为氟尿嘧啶结束之后立即点滴静脉注射的Rebohorinato。这是连续两天进行，每2周重复。
(2) 成人：一次250毫克体表面积/平方米以上一个周期2小时注射一次输注静脉作为Rebohorinato的。立即Rebohorinato输注静脉注射端至2600mg/平方米（体表面积）中24小时连续输注作为氟尿嘧啶之后。经过反复六次每星期，两个星期的休息。
(3) 成人：一次200毫克体表面积/平方米以上一个周期2小时注射一次输注静脉作为Rebohorinato的。点滴静脉注射Rebohorinato静脉注射400毫克/平方米（体表面积），为氟尿嘧啶，进一步2400-3000毫克/平方米（体表面积），以46小时的连续输注作为氟尿嘧啶结束之后立即。这是每两周重复。
应当指出的是，年龄，要正确使用，由于患者的状况。
5. Rebohorinato氟尿嘧啶持续静脉不能手术切除的胰腺癌注意联合用药
对成年人：一次200毫克体表面积/平方米以上一个周期2小时注射一次输注静脉作为Rebohorinato的。静脉注射400毫克/平方米（体表面积），为氟尿嘧啶，进一步2400mg/平方米（体表面积），以46小时的连续输注作为氟尿嘧啶结束之后立即点滴静脉注射的Rebohorinato。这是每两周重复。
应当指出的是，年龄，要正确减肥由于患者的状况。
药效药理
1.抗肿瘤（小鼠移植瘤的数据）
NCI（国家癌症研究所，美国）显示稍微有效或更多抗肿瘤为抗癌剂的筛选模型。
见药理学表
2. 作用机序
5-FU的抗肿瘤效果，主要认为是基于抑制DNA合成的F-脱氧UMP所得的5-FU掺入肿瘤细胞作为尿嘧啶合成胸苷原路经受代谢对酶，通过抑制胸苷酸的合成和拮抗脱氧UMP，认为DNA合成被抑制。
另一方面，5-FU是与生成一样还内置的F-RNA与RNA和尿嘧啶，还已知的是抑制核糖体RNA的形成，是这种药物这些事情的抗肿瘤效果表现据信参与。
包装规格
5-FU注为250mg：10瓶
5-FU注为1000毫克：5瓶
制造厂商
协和发酵麒麟有限公司
注：以上中文资料仅供参考，使用以原处方为准：http://www.info.pmda.go.jp/go/pack/4223401A3022_1_08/
5-FU Injection（Fluorouracil）
5-FU Injection 250mg（5-FU注250mg）
Brand name : 5-FU Injection 250mg
　Active ingredient: Fluorouracil
　Dosage form: injection
　Print on wrapping: 
5-FU Injection 1000mg（5-FU注1000mg）
Brand name : 5-FU Injection 1000mg
　Active ingredient: Fluorouracil
　Dosage form: injection
　Print on wrapping:
Effects of this medicine
This medicine has effects to suppress proliferation of cancer cells by inhibiting synthesis and functions of the cancer cell gene.
It is usually used in the treatment of gastric cancer, liver cancer, colorectal cancer, breast cancer, pancreatic cancer, cervical cancer, endometrial cancer and ovarian cancer. It is also used for esophageal cancer, lung cancer, head and neck cancer and pancreatic cancer difficult to be removed by surgery in combination therapy with other drugs or radiation.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have: myelosuppression, hepatic dysfunction, renal dysfunction, infection.
If you have heart disease or a history of it.
If you have gastrointestinal ulcer or haemorrhage, or varicella (chickenpox).
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, this medicine is injected intravenously or administered by intravenous infusion. It may be administered by intraarterial injection if necessary.
•Duration of administration may vary by other concomitant drug and condition of the patient. Ask your doctor about your dosing schedule.
Precautions while taking this medicine
•Possible adverse reactions to this medicine
The most commonly reported adverse reactions include loss of appetite, diarrhea, loose stool, general malaise, nausea, vomiting, stomatitis, pigmentation, alopecia, rash, degeneration of artery wall around catheter tip and thrombus formation. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•severe diarrhea, impaired consciousness, deep large breathing  [dehydration]
•intense abdominal pain, diarrhea, hematochezia  [serious enterocolitis (haemorrhagic enterocolitis, ischaemic enterocolitis, necrotising enterocolitis, etc.)]
•general malaise, bruise, dizziness  [myelosuppression (leukopenia, anaemia, thrombocytopenia, etc.)]
•rash, breathing difficulty, decreased blood pressure  [shock, anaphylaxis]
•unsteady gait, numbness of terminal portion of extremities, impaired tongue movement  [leukoencephalopathy]
•chest pain, cold sweat, feeling of strong pressure in chest  [congestive heart failure, myocardial infarction, angina at rest]
•general swelling, fatigability, difficulty in urination  [acute renal failure]
•fever, dry cough, difficult to breathe  [interstitial pneumonia]
•general malaise, loss of appetite, yellowing in skin and white of eyes, flapping tremor in hands  [hepatic function disorder, jaundice, hepatic failure, hepatic and biliary tract disorder (cholecystitis, bile duct necrosis, parenchymal disorder of liver, etc.)]
•nausea, vomiting, gastric pain, oral erosion and pain  [gastrointestinal ulcer, serious stomatitis]
•sudden intense pain in low back and back, fever, nausea, vomiting  [acute pancreatitis]
•impaired consciousness, flapping tremor in hands, tremor in limbs  [hyperammonemia with consciousness disorder]
•hypesthesia and supersensitivity, pain, skin exfoliation in volar  [hand-foot syndrome]
•difficult to smell, feel no smell  [dysosmia, anosmia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above
Kyowa Hakko Kirin Co.,LtdInjection
Revised: 5/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.