部份中文IV EMEND处方资料（仅供参考）
药品名称：福沙吡坦二甲葡胺
剂型规格：注射剂，150mg/
适应症：防治化疗或手术引发的恶心呕吐。
用法用量：本品推荐剂量为115mg，给药方法为静脉注射(15分钟)。
【国内外研究现状】
默克公司于2008年1月在美国和欧洲获批用于恶心呕吐（CINV）；08年5月在英国获批用于CINV； 2011年9月在日本获批用于CINV。
【特点】
福沙吡坦用于预防化疗引起的急性和延迟性恶心、呕吐，是阿瑞匹坦口服制剂的前体药物，静脉注射后迅速转化为阿瑞匹坦。
临床药代学研究表明，健康志愿者静脉输注115mg福沙匹坦15分钟或口服125mg阿瑞匹坦，输液结束后30分钟内，福沙匹坦的血药浓度即降至或低于定量限浓度10ng/ml，福沙匹坦几乎完全转化为阿瑞匹坦。给药后4~5小时，前者血浆中阿瑞匹坦浓度较后者高，但之后两者浓度相近。该项临床研究表明，本品115 mg 注射与口服阿瑞吡坦125 mg 呈生物等效性。
通过采用静脉注射给药，避免了口服给药的许多问题，特别适用于一些不便于口服给药的临床环境，比如患者意识不清楚，在恶心呕吐期间不能口服，或患者患口腔粘膜炎等情形。因此，福沙吡坦对于口服阿瑞匹坦来说是个很好的补充。

Medication name
Generic name: Fosaprepitant - Injection
Brand name(s): Emend
Uses
Fosaprepitant is used with other medications to help prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). Fosaprepitant works by blocking one of the body's natural substances (substance P/neurokinin 1) that causes vomiting.This medication will not treat nausea or vomiting if you already have it. Contact your doctor for further instructions if you are experiencing nausea or vomiting.
How to use
Read the Patient Information Leaflet available from your pharmacist before you start using this medication and each time you get a refill or receive treatment. If you have any questions, consult your doctor or pharmacist.This medication is given by injection into a vein by a health care professional. Fosaprepitant is usually given as a single dose 30 minutes before your chemotherapy or as directed by your doctor. On the following 2 days, you will usually take the form of this medication given by mouth (aprepitant). If you have any questions, consult your doctor or pharmacist.Rarely, a very serious allergic reaction to this drug might occur while your dose is being given (infusion reaction). Tell your health care professional immediately if you experience any side effects such as flushing, redness, or trouble breathing during your treatment. The infusion may need to be stopped. If the infusion is stopped, tell your doctor about the infusion reaction and do not use fosaprepitant again.Tell your doctor if you develop nausea or vomiting.
Precautions
Before using fosaprepitant, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.
Drug interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: cisapride, drugs affecting liver enzymes that remove fosaprepitant from your body (such as azole antifungals including itraconazole, macrolide antibiotics including erythromycin, cimetidine, rifamycins including rifabutin, St. John's wort, certain anti-seizure medicines including carbamazepine/phenytoin, certain cancer chemotherapy drugs including ifosfamide/vinblastine/vincristine), pimozide.Fosaprepitant can both speed up and slow down the removal of other drugs from your body, thereby affecting how they work. These affected drugs include (not a complete list): benzodiazepines (e.g., alprazolam, midazolam, triazolam), simvastatin, drugs to treat erectile dysfunction-ED or pulmonary hypertension (e.g., sildenafil, tadalafil).If you take warfarin, this drug may affect how well warfarin works in your body. Therefore, your doctor should test your blood during the 2 weeks after your fosaprepitant treatment to measure how well warfarin is working.This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication and for 1 month after the last dose of this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.
Side effects
See also How To Use section.Tiredness and hiccups may occur. If either of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Missed dose
It is important that you receive the dose before cancer chemotherapy as directed by your doctor. If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule.
Overdose
If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Notes
Not applicable.
Storage
Not applicable. This medication is given in a clinic and will not be stored at home.
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产地国家:德国
IV EMEND 150MG x 1Vial