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Emend IV(Fosaprepitant Dimeglumine)

2013-06-03 21:14:46 作者：新特药房来源：互联网浏览次数：295 文字大小：【大】【中】【小】

简介：英文药名: Emend IV(Fosaprepitant Dimeglumine) 中文药名: 福沙吡坦二甲葡胺注射液生产厂家: Merck & Co. Inc.药品简介【商品名】Emend 150MG/vial 【英文药品名】FOSAPREPITANT DIMEGLUMINE 【中文参考药品 ...

关键字：福沙吡坦二甲葡胺注射液 Emend IV 恶心止呕吐

英文药名: Emend IV(Fosaprepitant Dimeglumine)

中文药名: 福沙吡坦二甲葡胺注射液

生产厂家: Merck & Co. Inc.
药品简介
【商品名】Emend 150MG/vial
【英文药品名】FOSAPREPITANT DIMEGLUMINE
【中文参考药品】福沙吡坦二甲葡胺
【生产厂家】默克
美国fda批准默克公司的福沙吡坦二甲葡胺注射剂（fosaprepitant dimeglumine，emend）上市，与其它止吐药联用静脉注射防治中等催吐和大剂量催吐的药化疗（包括大剂量顺铂）初始和反复用药引起的急性和迟后的恶心和呕吐。
本品是阿瑞吡坦（aprepitant）口服制剂的前体药物，注射后在体内迅速转化成阿瑞吡坦。
美国fda批准福沙吡坦二甲葡胺注射剂上市是基于临床研究显示，本品115 mg注射后与口服阿瑞吡坦125 mg呈生物等效性。在研究中报道的不良反应为输注部位疼痛（7.6%）、输注部位硬结（1.5%）和头痛（3%）。
由于福沙吡坦二甲葡胺注射后在体内转化成阿瑞吡坦，因此口服制剂出现的不良反应在注射剂中也会发生，如倦困、恶心、打呃、便秘、腹泻、食欲减退、头痛和掉发。
福沙吡坦二甲葡胺与阿瑞吡坦属于称作人p物质/神经激肽1（nk-1）选择性高亲和性受体阻断剂，主要通过阻断大脑恶心和呕吐信号新颖的作用机制发挥作用。瑞吡阿坦对5-羟色胺（5-ht3）、多巴胺和糖皮质激素受体极微弱或*亲和性，用于治疗化疗诱导的恶心和呕吐及术后恶心和呕吐。阿瑞吡坦在动物模型上显示通过中枢神经作用抑制诸如顺铂等细胞毒化疗药物诱导的呕吐。
阿瑞吡坦以动物和人正电子发射断层照相术（pet）研究表明，药物穿过血脑屏障并占据了脑nk-1受体。对动物和人的研究显示，阿瑞吡坦增大5-ht3受体阻断剂昂丹司琼和糖皮质激素地塞米松的止吐作用，抑制顺铂诱导的急性期和迟后期呕吐。
Medication name
Generic name: Fosaprepitant - Injection
Pronunciation: (phos-a-PREP-ih-tant)
Brand name(s): Emend
Uses
Fosaprepitant is used with other medications to help prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). Fosaprepitant works by blocking one of the body's natural substances (substance P/neurokinin 1) that causes vomiting.This medication will not treat nausea or vomiting if you already have it. Contact your doctor for further instructions if you are experiencing nausea or vomiting.
How to use
Read the Patient Information Leaflet available from your pharmacist before you start using this medication and each time you get a refill or receive treatment. If you have any questions, consult your doctor or pharmacist.This medication is given by injection into a vein by a health care professional. Fosaprepitant is usually given as a single dose 30 minutes before your chemotherapy or as directed by your doctor. On the following 2 days, you will usually take the form of this medication given by mouth (aprepitant). If you have any questions, consult your doctor or pharmacist.Rarely, a very serious allergic reaction to this drug might occur while your dose is being given (infusion reaction). Tell your health care professional immediately if you experience any side effects such as flushing, redness, or trouble breathing during your treatment. The infusion may need to be stopped. If the infusion is stopped, tell your doctor about the infusion reaction and do not use fosaprepitant again.Tell your doctor if you develop nausea or vomiting.
Precautions
Before using fosaprepitant, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.
Drug interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: cisapride, drugs affecting liver enzymes that remove fosaprepitant from your body (such as azole antifungals including itraconazole, macrolide antibiotics including erythromycin, cimetidine, rifamycins including rifabutin, St. John's wort, certain anti-seizure medicines including carbamazepine/phenytoin, certain cancer chemotherapy drugs including ifosfamide/vinblastine/vincristine), pimozide.Fosaprepitant can both speed up and slow down the removal of other drugs from your body, thereby affecting how they work. These affected drugs include (not a complete list): benzodiazepines (e.g., alprazolam, midazolam, triazolam), simvastatin, drugs to treat erectile dysfunction-ED or pulmonary hypertension (e.g., sildenafil, tadalafil).If you take warfarin, this drug may affect how well warfarin works in your body. Therefore, your doctor should test your blood during the 2 weeks after your fosaprepitant treatment to measure how well warfarin is working.This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication and for 1 month after the last dose of this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.
Side effects
See also How To Use section.Tiredness and hiccups may occur. If either of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Missed dose
It is important that you receive the dose before cancer chemotherapy as directed by your doctor. If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule.
Overdose
If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Notes
Not applicable.
Storage
Not applicable. This medication is given in a clinic and will not be stored at home.
Photos by medication strength
Click the "Photos" link to see sample photographs for a specific medication strength.
Common strengths
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注：以下产品不同规格和不同价格，购买以咨询为准！
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产地国家: 英国
原产地英文商品名:
EMEND IV INJ 115mg/vial 3vials/box
原产地英文药品名:
FOSAPREPITANT DIMEGLUMINE
中文参考商品译名:
EMEND IV注射剂 115毫克/瓶 3瓶/盒
中文参考药品译名:
福沙吡坦二甲葡胺
生产厂家中文参考译名:
默克
生产厂家英文名:
Merck

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产地国家: 加拿大
原产地英文商品名:
EMEND IV INJ 150MG/vial
原产地英文药品名:
FOSAPREPITANT DIMEGLUMINE
中文参考商品译名:
EMEND IV注射剂 150毫克/瓶
中文参考药品译名:
福沙吡坦二甲葡胺
生产厂家中文参考译名:
默克
生产厂家英文名:
Merck
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产地国家: 美国
原产地英文商品名:
EMEND IV INJ 150MG/10mls/vial
原产地英文药品名:
FOSAPREPITANT DIMEGLUMINE
中文参考商品译名:
EMEND IV注射剂 150毫克/10毫升/瓶
中文参考药品译名:
福沙吡坦二甲葡胺
生产厂家中文参考译名:
美国默克
生产厂家英文名:
Merck