FLAGYL I.V. INJECTION
通用名称和剂型：
甲硝唑500毫克/100毫升。
公司名称：
辉瑞公司
【适应症】用于静脉注射FLAGYL注：
敏感厌氧菌感染。手术预防用药。
成人剂量的静脉注射FLAGYL注：
注入用1小时。厌氧菌感染：15毫克/千克（负荷剂量），然后7.5mg/ kg，每6小时;最大4G /天。预防：见文献。
儿童剂量静脉注射FLAGYL注：
不推荐使用。
不良反应：
癫痫，周围神经病变，胃肠不适，食欲减退，便秘，头痛，金属味，ECT变化，尿痛。
Metronidazole Injection, USP RTU® is supplied in 100 mL single dose plastic containers, each containing an iso-osmotic, buffered solution of 500 mg metronidazole as follows:
500mg/100 mL
Store at controlled room temperature, 59° to 86°F (15° to 30°C) and protect from light during storage. Do not remove unit from overwrap until ready for use. The overwrap is a moisture barrier. The inner bag maintains the sterility of the product. After removing overwrap, check for minute leaks by squeezing inner bag firmly. If leaks are found, discard solution as sterility may be impaired.
Flagyl I.V.
Flagyl I.V. - A nitroimidazole used to treat amebiasis; vaginitis; trichomonas infections; giardiasis; anaerobic bacteria; and treponemal infections. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck).
Indication: For the treatment of anaerobic infections and mixed infections, surgical prophylaxis requiring anaerobic coverage, Clostridium difficile-associated diarrhea and colitis, Helicobacter pylori infection and duodenal ulcer disease, bacterial vaginosis, Giardia lamblia gastro-enteritis, amebiasis caused by Entamoeba histolytica, acne rosacea (topical treatment), and Trichomonas infections.
Flagyl I.V., a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Flagyl I.V. is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.

FLAGYL I.V. INJECTION Rx

Generic Name and Formulations:
Metronidazole 500mg/100mL.

Company:
Pfizer Inc.
Indications for FLAGYL I.V. INJECTION:
Susceptible anaerobic infections. Surgical prophylaxis.

Adult Dose for FLAGYL I.V. INJECTION:
Infuse over 1 hour. Anaerobic infections: 15mg/kg (loading dose), then 7.5mg/kg every 6 hours; max 4g/day. Prophylaxis: see literature.

Children's Dose for FLAGYL I.V. INJECTION:
Not recommended.

See Also:
FLAGYL

FLAGYL 375

Pharmacological Class:
Nitroimidazole.

Contraindications:
Pregnancy (1st trimester for trichomoniasis).

Warnings/Precautions:
CNS disease. Discontinue if neurological symptoms occur. Severe hepatic disease: reduce dose. Candidiasis. History of blood dyscrasias. Monitor leukocytes before and after therapy. Elderly: monitor serum levels. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:
Avoid alcohol during and for 3 days after use. Do not give within 2 weeks of disulfiram (possible psychotic reactions). May potentiate oral anticoagulants, phenytoin, lithium. Antagonized by phenobarbital, phenytoin, other hepatic enzyme inducers. May impair phenytoin clearance. Potentiated by cimetidine, other hepatic enzyme inhibitors. Interferes with serum chemistry tests.

Adverse Reactions:
Seizures, peripheral neuropathy, GI upset, anorexia, constipation, headache, metallic taste, ECT changes, dysuria.

How Supplied:
Tabs—50, 100; Caps 375mg—50; IV—24