英文药名：BFLUID Injection（Thiamine (Vitamin B1)）

中文药名：硫胺素（维生素B1）輸液

生产厂家：大冢制药

ビーフリード輸液（５００ｍＬ袋）／ビーフリード輸液（１０００ｍＬ袋）

类别名称
维生素B1·糖，电解质，氨基酸溶液
商標名
BFLUID Injection
药品名称
硫胺素（维生素B1）
药效药理
检查用5维生素B1补充作用，营养作用和电解质补充作用和维生素B1缺乏症剖腹侵袭性鼠。其结果是，血液中维生素B1的浓度正常大鼠和正常狗，一个也保持在以前的值水平给药，血液中维生素B1的浓度在给药后的维生素B1缺乏正常水平剖腹侵入大鼠给药后比，它已恢复到时，观察到这种药物的维生素B1的补充效果。此外，营养作用和此试剂的电解质补充效果相当于与对照药物（氨基弗里德输注）
适应症
电解质，维生素B1和水分补给时氨基酸
•口服摄取不足，如果是在温和的低蛋白血症或轻度的低营养状态。
·手术前，后
剂量和给药方法
拌匀上室溶液和下室的溶液在使用时打开的分区。通常情况下，一次500mL将静脉输液在成人外周静脉。给药速率，通常，成人的500mL120分钟作为参考，老人，进一步注射慢慢危重病人。
此外，年龄，症状，并将根据体重调整，最大剂量被假定为1天2500mL
包装规格
500mL*20袋（软袋）

1000mL*10袋（软袋）

制造厂商
大冢有限公司制药厂
注：以上部份中文资料仅供参考，使以原处方为准
附：http://www.info.pmda.go.jp/go/pack/3259529G1030_1_06/
BFLUID Injection (500mL)（ビーフリード輸液（500mL））
Brand name : BFLUID Injection (500mL)
　Active ingredient: Thiamine (Vitamin B1), Glucose, Electrolyte, Amino acids
　Dosage form: injection
　Print on wrapping:
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BFLUID Injection (1000mL)（ビーフリード輸液（1000mL）） 
Brand name : BFLUID Injection (1000mL)
　Active ingredient: Thiamine (Vitamin B1), Glucose, Electrolyte, Amino acids
　Dosage form: injection
　Print on wrapping:
Effects of this medicine
This medicine is a mixed infusion of thiamine, glucose, electrolyte, and amino acids, which is used to replenish these nutrients in patients who are; unable to take an adequate diet, slightly malnutritioned with low protein levels in the blood, or in a perioperative period.
It is usually used for replenishment of amino acids, electrolyte, thiamine, and fluid when the patient is unable to take an adequate diet, slightly malnutritioned with low protein levels in the blood, or in the perioperative period. 
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
•If you have; hepatic coma/a risk of hepatic coma, renal impairment/azotemia, congestive heart failure, severe acidosis (such as hyperlacticacidemia), abnormal electrolyte metabolism (such as hyperkalemia, hyperphosphatemia, hypermagnesemia, or hypercalcemia), decreased urine output due to obstructive uropathy, or amino acid metabolism abnormality.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•This medicine is usually administered by intravenous (IV) drip infusion. Please ask your doctor for details regarding duration of administration.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
Reported adverse reactions include angialgia and phlebitis (pain in a blood vessel at an injection site and swelling), nausea, vomiting and chest discomfort. If any of symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•dizziness, shortness of breath, loss of consciousness [shock]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Otsuka Pharmaceutical Factory Inc.Injection
Published: 12/2013

Vitamin B1 · Sugar · Electrolyte · Amino Acid Drip Injection Kit Formulation
"For beef lead IV drip infusion"
June 14 Release of Otsuka Pharmaceutical Factory (headquarters: Naruto city, Tokushima Prefecture, President: Ichiro Otsuka) announced on June 9th vitamin B1 · sugar · electrolyte · amino acid solution listed on the drug price "for beef lead intravenous infusion We will release it on June 14th.
"For beef lead intravenous infusion" is a kit formulation for peripheral intravenous infusion with vitamin B1 essential for carbohydrate metabolism, sugar, electrolyte, and amino acid solution.
"For beef lead intravenous infusion", it is possible to open the bulkhead part by a single operation, and it is possible to mix and prepare vitamin B1 and sugar, electrolyte, amino acid simply and aseptically.
We believe that simultaneous administration of vitamin B1 in peripheral venous nutrition therapy prevents vitamin B1 deficiency and reduces risk.
Peripheral intravenous nutrition therapy is a nutritional therapy that is administered to patients whose nutritional intake through the gastrointestinal tract is impossible or inadequate before and after surgery and mild malnutrition. Vitamin B1 is essential for the metabolism of carbohydrates, it is a vitamin that is deficient in the early stage if it does not ingest a variety of vitamins with less storage in the body. In clinical practice, in order to prevent vitamin B1 deficiency, glucose, electrolytes, amino acid injections and vitamins are often mixed and administered before administration.
Otsuka Pharmaceutical Co., Ltd. will co-market "Beef Lead Infusion IV".
Characteristics of "Beef lead intravenous infusion" Features 1. It is a drip injection for peripheral vein, which is a single preparation of vitamin B1 in addition to glucose, electrolytes and amino acids.
2. Vitamin B1 can be conveniently supplemented by the combination of vitamin B1 and has the effect of maintaining blood concentration.
3. It became possible to keep the stability of vitamin B 1 for a long time compared with the case where it is mixed with the conventional peripheral venous nutrition formulation.
4. To prevent the decomposition of vitamin B1, a transparent UV-cut outer bag is used, which makes it easy to confirm the product from the outside.
5. Potassium was divided into upper and lower chambers and blended to eliminate the risk of erroneously receiving high concentration of potassium.
History of development Nutritional supplement therapy via a peripheral vein is effective in cases where it is impossible or insufficient to ingest nutrients through the gastrointestinal tract before and after surgery and in patients with mild malnutrition, moisture, sugar , Electrolytes and amino acids can be supplied at the same time as nutritional supplement therapy, which is widely practiced in the medical field.
In general, peripheral venous nutrition therapy has been thought to be less prone to deficiency of vitamin B1 which is necessary for sugar metabolism because there are few sugars to be administered and the administration period is short, but if the amount of vitamin B1 stored in the body is It is said that it is said to be the shortest if not taken among various vitamins, and its deficiency is clinically severe such as Wernicke's encephalopathy and metabolic acidosis. Furthermore, in recent years, there is also a report that the concentration of vitamin B1 in the blood is lowered by peripheral vein nutrition therapy which does not use vitamin B1 at the same time.
Against this backdrop, we have developed "Beef lead IV infusion IV", which can be easily supplemented with vitamin B 1 in a conventional peripheral venous nutrition formulation and can maintain vitamin B 1 concentration in the blood .
Outline of "For beef lead drip infusion" Sales name "For beef lead intravenous infusion"
(English notation: BFLUID for I.V.Infusion)
Type Vitamin B1 · sugar · electrolyte · amino acid solution
Packing beef lead For intravenous infusion: 500 mL 20 bag soft bag
For beef lead infusion IV: 1000 mL 10 bag softbag
Room composition (amino acid · electrolyte solution)
L-leucine, L-isoleucine, L-valine, L-lysine hydrochloride, L-threonine, L-tryptophan, L-methionine, acetyl cysteine, L- phenylalanine, L- tyrozine, L- arginine, L-histidine, Alanine, L-proline, L-serine, glycine, L-aspartic acid, L-glutamic acid, dipotassium phosphate, sodium hydrogen phosphate, sodium citrate, sodium lactate
Lower chamber fluid (vitamin B1 · sugar · electrolyte solution)
Glucose, potassium chloride, calcium chloride, magnesium sulfate, zinc sulfate, thiamine hydrochloride
Indications of amino acids, electrolytes, vitamin B 1 and moisture at the following conditions
1. Inadequate ingestion, mild hypoproteinemia or mild malnutrition
2. Before and after surgery
Open the bulkhead and mix well with upper chamber fluid and lower chamber fluid at the time of usage / dosage. Usually, adults are intravenously infused intravenously into the peripheral vein with 500 mL once. The administration rate is usually based on 120 minutes per 500 mL of adult, and is injected more slowly to elderly people and serious patients. Incidentally, it will be increased or decreased according to age, symptoms, body weight, but the maximum dose should be up to 2,500 mL per day.
Storage method Light shielded · room temperature preservation
Expiration date 18 months after manufacture
Approval date March 3, 2006
Manufacturing distributor Co., Ltd. Otsuka Pharmaceutical Factory
Sales alliance Otsuka Pharmaceutical Co., Ltd.