英文药名：APTECIN（Rifampicin Capsules）

中文药名：利福平胶囊

生产厂家：科研制药

アプテシンカプセル150mg

类别名称
利福平配方
商標名
APTECIN Capsules 150mg
一般名
リファンピシン（Rifampicin）
化学名
(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-(4-methylpiperazin-1-yliminomethyl)-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-21-yl acetate
分子式
C43H58N4O12
分子量
822.94
構造式

性状
利福平是橙红色的结晶或结晶性粉末至红棕色。
水，乙腈，微溶于甲醇或乙醇（95）。
操作注意事项
稳定性试验
使用最终包装产品在处方改变（40℃，75％，相对湿度3个月）的结果，对时间相对比较测试是相当于旧制剂是稳定三年已经确定，这个代理据推测，在正常的市场分布为期三年的稳定。
条件批准
<审批条件麻风额外指示>
对于麻风病，世卫组织是一个大规模，双盲，对照多药联合治疗的临床试验，目前正在开展年底，功效和作用的结果公布的时候，审查剂量和给药
适应病症
<适应的物种>
灵敏度的分枝杆菌对这种药物
<适应症>
肺结核和其他结核病，鸟分枝杆菌复合物（MAC）的疾病非结核分枝杆菌疾病，包括麻风病
用法用量
[肺结核等结核病]
成人，一次450毫克（效价）利福平（3粒）每日一次每日口服给药。然而，当有一个感性组合剂可以是在两天，每周施用。
作为一般规则和早餐前禁食给药，以增加或减少取决于患者的年龄和症状。此外，在与其它抗结核剂组合是理想。
[非结核分枝杆菌病，包括MAC疾病]
成人，一次450毫克（效价）利福平（3粒）每日一次每日口服给药。
作为一般规则和早餐前禁食给药，年龄，症状，并根据体重调整，每日最大剂量不超过600毫克（效价）（4胶囊）。
[麻风病]
成人，一次600毫克（效价）利福平（4-胶囊）一次或两次，每天一次口服给药一个月一次450毫克（效价）（3粒）一天。
作为一般规则和早餐前禁食给药，以增加或减少取决于患者的年龄和症状。此外，它在与其它抗麻风病制剂联合使用。
包装规格
（PTP）100胶囊
（塑料容器）500胶囊

制造厂商
科研制药有限公司

注：以上中文信息资料仅供参考，使用以原处方为准：http://www.info.pmda.go.jp/go/pack/6164001M1208_1_12/
APTECIN Capsules（Rifampicin）アプテシンカプセル150mg
APTECIN Capsules 150mg（アプテシンカプセル150mg） 
Brand name : APTECIN Capsules 150mg
　Active ingredient: Rifampicin
　Dosage form: capsule with blue opaque cap and pale blue opaque body, entire length: 15.8 mm
　Print on wrapping: アプテシンカプセル150mg, APTECIN Cap.150mg, 150mg（力価）, KC-245, リファンピシン
Effects of this medicine
This medicine is a chemotherapeutic agent and shows antibacterial effect by inhibiting RNA synthesis of Mycobacterium tuberculosis or Mycobacterium leprae.
It is usually used to treat pulmonary tuberculosis, other tuberculosis, nontuberculous mycobacteriosis including Mycobacterium avium complex (MAC), and Hansen's disease.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have biliary atresia or liver disorder.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
For pulmonary tuberculosis and other tuberculosis: In general, for adults, take 3 capsules [450 mg (potency) of the active ingredient] at a time, once daily, everyday. However, if you need to take other antituberculosis medicines concomitantly, you may be instructed to take the medicine 2 days a week. Take the medicine before breakfast on an empty stomach in principle. The dosage may be adjusted according to your age or symptoms. Strictly follow the instructions.
For nontuberculous mycobacteriosis including MAC: In general, for adults, take 3 capsules [450 mg (potency) of the active ingredient] at a time, once daily, everyday. Take the medicine before breakfast in principle. The dosage may be adjusted according to your age, symptoms or weight, however, the maximum daily dose is 4 capsules [600 mg (potency)]. Strictly follow the instructions.
For Hansen's disease: In general, for adults, take 4 capsules [600 mg (potency) of the active ingredient] at a time once to twice a month, or take 3 capsules [450 mg (potency) of the active ingredient] at a time, once daily, every day. Take the medicine before breakfast on an empty stomach in principle. The dosage may be adjusted according to your age or symptoms. It is considered desirable to use concomitantly with other anti-Hansen medicines. Strictly follow the instructions.
If you miss a dose, take the missed dose as soon as possible. However, take an interval of about 8 hours before the next dose. If it is 2 to 3 hours or less before the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include loss of appetite, nausea, vomiting, stomachache and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
general malaise, loss of appetite, nausea, vomiting, jaundice [serious liver disorder including fulminant hepatitis]
chill, facial flushing, breathing difficulty [shock, anaphylactoid symptoms]
general malaise, palpitation, dizziness [hemolytic anemia]
fever, erythema, blister, erosion [toxic epidermal necrolysis, oculomucocutaneous syndrome, lichen planus-type eruption, pemphigus-like eruption, pemphigoid eruption, erythroderma (exfoliative dermatitis)]
?fever, dry cough, breathing difficulty [interstitial pneumonia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
Discard the remainder. Do not store them.
Kaken Pharmacetical Co.,LtdInternal
Revised: 9/2011
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.