英文药名：Julina（Estradiol Tablets）

中文药名：雌二醇片

生产厂家：拜耳药品

ジュリナ錠0.5mg

治疗类别名称
口服雌激素制剂
商標名
Julina 0.5mg
構造式

一般名
エストラジオール（Estradiol）
化学名
Estra-1,3,5（10）-triene-3,17β-diol
分子式
C18H24O2
分子量
272.38
融点
175～180℃
性状
本品是一种白色晶体或细小的黄色结晶粉末，没有异味。
此产品可自由可溶于1,4-二恶烷或N，所述N-甲基甲酰胺，容易微溶于丙酮，乙醇（95），以微溶，在乙醚中微溶，并且几乎不溶于水。此产品可溶于硫酸。本产品是吸湿。
适应病症
●下列与绝经有关的症状和卵巢缺失症状
血管舒缩症状（潮热多汗），腟萎萎缩症状
●绝经后骨质疏松
用法用量
●与绝经有关的症状和卵巢缺失症状
成人；每天一次，每次口服0.5mg。增重的情况下，每天一次，第次口服为1.0mg。
●绝经后骨质疏松
成人；每天一次，每次口服1.0mg。
药效药理
1. 雌二醇（E2）是角质形成细胞的阴道上部皮肤，减少的阴道和子宫的唾液酸含量，引起阴道和子宫重量增加，它抑制了分泌和排卵和促黄体激素和促卵泡激素的植入。
2. 当雌激素由于卵巢功能的降低迅速下降的分泌，导致雌激素依赖性功能和组织的改变。作为能代表失败的，由于这种持续的雌激素下降，出现潮热，出汗等。这种药物由E2口服加血雌激素水平，减少这些症状。
3. 当从卵巢切除手术日期的E2为1.5μg/kg/天进行28天皮下对大鼠给药，E2表现出抗由于卵巢切除的胫骨松质骨矿物密度）降低的预防作用。
4. 当从手术大鼠的卵巢切除术当天E24微克/公斤/天的28天皮下施用，E2表现出抗由于卵巢切除的胫骨松质骨矿物密度）降低的预防作用。
5. 当24周皮下E2为5μg/ kg /天的大鼠后卵巢切除29天施用，E2显示对胫骨和腰椎由于卵巢切除松质骨矿物密度）的还原的治疗效果。
包装规格
片剂
0.5mg PTP包装140片（28片×5），280片（28片×10）

制造商（进口）
拜耳药品社有限公司

Julina Tablets（Estradiol）
Brand name : Julina Tablets 0.5mg
　Active ingredient: Estradiol
　Dosage form: bright grayish-yellow tablet, diameter: 6 mm, thickness: 2.85 mm
　Print on wrapping: (face) ジュリナ錠 0.5 mg, HM
(back) ジュリナ錠 0.5 mg, Julina 0.5 mg, 0.5 mg
Effects of this medicine
This medicine relieves symptoms due to decreased ovarian hormones by supplementing estradiol, a type of ovarian hormone. It also suppresses decreasing bone quantity.
It is usually used to treat hot flush, sweating or vaginal dryness associated with climacteric disorder/ovarian deficiency symptoms due to ovarian resection, or postmenopausal osteoporosis.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have or are suspected of having estrogen-dependent cancers (breast cancer, cancer of endometrium, etc.).
If you have a past medical history of breast cancer.
If you have or have a past medical history of thrombophlebitis, pulmonary embolism or arterial thromboembolic disease (coronary heart disease, stroke, etc.).
If you have liver disorder or undiagnosed abnormal genital bleeding.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•For symptoms associated with climacteric disorder/ovarian deficiency symptoms: In general, for adults, take 1 tablet (0.5 mg of the active ingredient) at a time, once a day. The dosage may be increased to 2 tablets (1.0 mg) at a time, once a day. For postmenopausal osteoporosis: In general, for adults, take 2 tablets (1.0 mg of the active ingredient) at a time, once a day.
In any case, strictly follow the instructions.
•If you miss a dose, take the missed dose as soon as you remember. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Avoid taking any food containing St. John's wort, since it may decrease the blood level of the medicine and diminish medicinal effects.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include genital discharge, breast discomfort, abdominal pain, genital bleeding, abdominal bloating, nipple pain and breast pain. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•leg pain/edema, chest pain, shortness of breath [venous thromboembolism, thrombophlebitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
http://www.info.pmda.go.jp/go/pack/2473001F1028_1_13/