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DIAPP SUPPOSITORIES(地西泮小儿用栓剂)

2016-05-18 19:09:29  作者:新特药房  来源:互联网  浏览次数:0  文字大小:【】【】【
简介: 英文药名:DIAPP SUPPOSITORIES(Diazepam) 中文药名:地西泮小儿用栓剂 生产厂家:高田製薬 ダイアップ坐剤4/ダイアップ坐剤6/ダイアップ坐剤10 治疗类别名称小儿惊厥商標名 DIAPP 一般名ジ ...

英文药名:DIAPP SUPPOSITORIES(Diazepam)

中文药名:地西泮小儿用栓剂

生产厂家:高田製薬

ダイアップ坐剤4/ダイアップ坐剤6/ダイアップ坐剤10

治疗类别名称
小儿惊厥
商標名
DIAPP
一般名
ジアゼパム[日局]Diazepam
化学名
7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
構造式

分子式
C16H13ClN2O
分子量
284.74
性状
在白色至淡黄色结晶粉末,没有气味,味道微苦。
易溶于丙酮,容易微溶于乙酸酐或乙醇(95),微溶在乙醚中,在乙醇(99.5)微溶,并且几乎不溶于水。
熔点
130〜134℃
适应病症
改善儿童高热惊厥和癫痫发作
用法用量
儿童
通常,1-2天次一次0.4-0.5mg/公斤,被插入到直肠。适当地增加或根据状况下降,应不超过1天1毫克/千克
药效药理
1. 用小鼠口服对比
(下表参照)
2. 作用机序
苯二氮受体在地西泮结合苯二氮受体中央,并使GABA受体复合物,为GABA受体的GABA增加亲和力,GABA的结合增加,氯离子推进通道的开通,抑制兴奋性突触的传导。

試験法  投与後30分のED50値(mg/kg)
直腸内投与 
投与後30分のED50値(mg/kg)
経口投与 
抗Bemegrideけいれん  0.25  0.56 
抗電撃けいれん  0.45  0.71 
包装规格
栓剂4mg:50(5×10)


栓剂6mg:50(5×10)


栓剂10mg:50(5×10)


生产商:高田製薬
完整处方资料附件:http://www.info.pmda.go.jp/go/pack/1124701J1022_2_03/
DIAPP SUPPOSITORIES(Diazepam) 
Brand name : DIAPP SUPPOSITORIES 4
 Active ingredient: Diazepam
 Dosage form: white to pale yellow translucent spindle-shaped suppository, length: approximately 26 mm
 Print on wrapping: 4mg, ダイアップ, TAKATA
Effects of this medicine
This medicine acts on central nerve system and suppresses excitement of nerve cells to improve symptoms of spasm.
It is usually used to improve febrile convulsion and convulsive seizure of epilepsy in children.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have acute narrow-angle glaucoma or myasthenia gravis.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for children, insert 0.4 to 0.5 mg of the active ingredient per kilogram of body weight into the rectum at a time, once to twice a day. The dosage should be adjusted according to your disease, age and symptoms. However, it should not exceed 1mg/kg per day. This preparation contains 4 mg of the active ingredient in a piece. Strictly follow the instructions.
•If you miss a dose, use the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never use two doses at one time.
•If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop using this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Pay attention to the child's condition after using this medicine since it may cause drowsiness or decrease in attention/concentration/reflex movement.
•Avoid drinking alcohol since it may intensify the effects of the medicine.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include drowsiness, lightheadedness and rash. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•unable to stop using this medicine despite trying to stop [dependence]
•disturbed consciousness (impaired thinking), impaired mind, hallucination [irritable excitation, confusion, etc.]
•breathing becomes shallow and fast, difficult to breath [respiratory depression]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
TAKATA SEIYAKU Co., Ltd.External
Published: 1/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.takata-seiyaku.co.jp/medical/product/t_1101/?product=product1101

责任编辑:admin


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