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E Keppra Dry syrup 50%（左乙拉西坦干糖浆）

2016-02-26 01:34:44 作者：新特药房来源：互联网浏览次数：45 文字大小：【大】【中】【小】

简介： 英文药名: E Keppra Dry syrup 50%（Levetiracetam）中文药名: 左乙拉西坦干糖浆生产厂家: 大冢制药类别名称抗癫痫药欧文商標名E Keppra Dry syrup 50％一般名レベチラセタム〔Levetiracetam（JAN） ...

关键字：左乙拉西坦干糖浆 Levetiracetam 药品商标名E Keppra Dry syrup 50% 抗癫痫药

英文药名: E Keppra Dry syrup 50%（Levetiracetam）

中文药名: 左乙拉西坦干糖浆

生产厂家: 大冢制药

イーケプラドライシロップ50％

类别名称
抗癫痫药
欧文商標名
E Keppra Dry syrup 50％
一般名
レベチラセタム〔Levetiracetam（JAN）〕
化学名
(2S)-2-(2-Oxopyrrolidine-1-yl)butyramide
構造式

分子式
C8H14N2O2分子量
170.21
融点
115〜119℃
性状
白色至淡灰白色结晶粉末。非常易溶于水，易溶于甲醇，乙醇（99.5），稍微更溶于2-丙醇和乙腈，甲苯和乙醚微溶，并在己烷中几乎不溶。
*分配系数
登录P =-0.60（pH7.4,1-辛醇/磷酸盐缓冲液）
药效药理
*对癫痫发作影响
如最大电击抽搐模型和最大戊四氮诱导的惊厥模型，这是一个典型的筛选模型，但没有表现出痉挛的抑制作用，角膜电刺激点燃鼠标，戊四点燃鼠标26）中，毛果芸香碱或红藻氨酸给药大鼠，斯特拉斯堡遗传性失神癫痫大鼠（GAERS），部分性发作，如小鼠听源性癫痫发作，反映全身性发作的癫痫动物模型，显示检抑制作用
*抗癫痫作用的免疫原性
在杏仁核的电刺激点燃癫痫鼠，它抑制了火种形成
*对中枢神经的其他作用
不影响在莫里斯水迷宫测试中的认知功能的影响，在转子杆测试没有影响运动功能。此外，它表明在中脑动脉结扎大鼠的神经细胞保护作用。
*作用机制
左乙拉西坦，各种受体和主要的离子通道，但不结合，结合于神经末梢的突触小泡蛋白2A（SV2A），N-型钙通道的抑制，无抑制的细胞内Ca 2+，GABA和甘氨酸工作变构抑制，如神经细胞之间的过多的同步抑制的抑制得到证实关于性电流。从发现结合亲和力和各种癫痫动物模型SV2A的，左乙拉西坦的结合和SV2A被认为有助于检动作检抑制作用之间的相关性。
适应病症
癫痫病人部分性发作（有或无继发性全身性发作）
用法用量
成人：
一般，成人溶解在使用的时间，每天分成每天1000毫克的2倍（2克干糖浆），为左乙拉西坦口服给药。如将适当地增加或不超过1天3000毫克（6克为干糖浆）的症状，体重的增加（2克干糖浆）为1000mg如在两周或更长它是由下列完成的时间间隔的每日剂量的范围内降低。
小児：
通常，溶解可以在儿童4岁及以上的（40毫克/千克作为干糖浆），每天两次被分成在使用时口服给药1日为20mg / kg的作为左乙拉西坦。此外，每日症状为60mg/ kg的将适当地增加或不超过（120毫克/千克作为干糖浆）的范围内的降低，增加了作为每日剂量在两个多星期为20mg / kg的间隔（40毫克/千克作为干糖浆）它是通过以下进行的。然而，在上述的儿科体重50kg，使用相同的给药方案和成年人
包装规格
瓶：100g 500g

生产商：大冢制药

E Keppra Dry syrup 50%（Levetiracetam）
E Keppra Dry syrup 50%（イーケプラドライシロップ50％）
Brand name : E Keppra Dry syrup 50%
　Active ingredient: Levetiracetam
　Dosage form: white to off-white dry syrup formulation
　Print on wrapping:
Effects of this medicine
This medicine controls epileptic seizures by suppressing excess excitation of brain nerves.
It is usually used to treat partial epileptic seizures.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have renal disorder or liver disorder.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•For adults: In general, for adults, take 2 g (1,000 mg of the active ingredient) a day in 2 divided doses. Dissolve the dry syrup with water just before use and take immediately. The dosage may be adjusted according to symptoms, but should not exceed 6 g (3,000 mg) a day. The dose may be increased by an increment not greater than 2 g (1,000 mg) daily with an interval of at least two weeks.
For children: In general, for children from 4 years of age, take 40 mg (20 mg of the active ingredient)/kg/day in 2 divided doses. Dissolve the dry syrup with water just before use and take immediately. The dosage may be adjusted according to symptoms, but should not exceed 120 mg (60 mg)/kg/day. The dose may be increased by an increment not greater than 40 mg (20 mg)/kg/day with an interval of at least two weeks. The dosage in children 50 kg or greater is the same as in adults.
1g of the dry syrup contains 500 mg of the active ingredient. Strictly follow the instructions.
•If you miss a dose, take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may cause sleepiness, memory loss (forgetfulness), loss of concentration, diminished responsiveness, etc. Avoid performing dangerous operations such as driving a car.
•Psychiatric symptom, such as change in mental or physical condition due to slight irritation, confusion, feeling irritated, easily excited and aggressive tendency, may occur and may lead to suicide attempt. If any of mental changes occur, check with your doctor or pharmacist.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include nasopharyngitis, somnolence, headache, dizziness, diarrhea, constipation and rash. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•fever, erythema, general malaise [toxic epidermal necrolysis: TEN, Stevens-Johnson syndrome]
•bleeding tendency, fever, sore throat [severe blood disorder (pancytopenia, leukocytopenia, neutropenia, thrombocytopenia)]
•general malaise, loss of appetite, yellowness in skin or conjunctiva [hepatic failure, hepatitis]
•severe upper abdominal pain, fever, nausea [pancreatitis]
•change in mental or physical condition due to slight irritation, aggressive tendency, attempt suicide [aggression, suicide attempt]
•muscle pain, lassitude, reddish brown urine [rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
•[To family members] The patient and his/her families need to receive information about the possibility of developing symptoms, such as aggressive behaviors and suicidal thoughts, until you fully understand it. Keep close contact with your doctor. If you notice unusual behavior and symptoms, consult your doctor or pharmacist immediately.
Otsuka Pharmaceutical Co., Ltd.Internal
Revised: 2/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
https://www.otsuka-elibrary.jp/di/prod/detail/init/ekd