美国最新的治疗尖锐湿疣药品

西多福韦
Cidofovir  
中文别名：  西多福韦、西道法韦 
英文别名：  Vistide 
生产企业：   
药品类别：  抗病毒类  

药理药动 
  Classification: Antiviral drug 
Action/Kinetics: A nucleotide analog that suppresses CMV replication by selective inhibition of viral DNA synthesis. The drug inhibits CMV DNA polymease. Must be administered with probenecid. 
适 应 症 
  Treatment of CMV retinitis in clients with AIDS. 
用法用量 
  IV Infusion CMV retinitis. Induction: 5 mg/kg given once weekly for 2 consecutive weeks as an IV infusion at a constant rate over 1 hr. Maintenance: 5 mg/kg given once q 2 weeks as an IV infusion at a constant rate over 1 hr. With each dose of cidofovir, probenecid, 2 g PO, must be given 3 hr prior to the cidofovir dose and 1 g PO given at 2 hr and again at 8 hr after completion of the 1-hr cidofovir infusion. Also, with each dose of cidofovir, the client should receive a total of 1 L of 0.9% NaCl solution IV over a 1- to 2-hr period just before the cidofovir infusion. If the client can tolerate it, give a second liter of 0.9% NaCl solution either at the start of the cidofovir infusion or immediately afterward and infuse over a 1- to 3-hr period. If serum creatinine increases by 0.3 to 0.4 mg/dL, reduce the dose of cidofovir from 5 to 3 mg/kg. Discontinue cidofovir if the serum creatinine increases by 0.5 mg/dL or more or if there is development of 3 + or more proteinuria.