健豪宁genotropin

健豪宁（注射用重组人生长激素）适用于生长激素分泌不足、或相关性腺发育不全、或特纳氏综合症所引起的生长发育障碍；青春期前慢性肾功能不全儿童的生长发育障碍；成人明显的生长激素不足替代疗法。

Indications
GENOTROPIN® (somatropin [rDNA origin] for injection) is prescribed for the treatment of growth failure in:

children who do not make enough growth hormone on their own. This condition is called growth hormone deficiency (GHD).
children who are born smaller than most babies born after the same number of weeks of pregnancy. Some of these babies may not show catch-up growth by age 2. This condition is called small for gestational age (SGA).
children with a genetic condition called Prader-Willi syndrome (PWS). Growth hormone is not right for all children with PWS. Check with your doctor.
girls with a genetic condition called Turner syndrome (TS). Growth hormone should be used to treat TS only in girls who are still growing.
Other causes of short height should be ruled out.

In adults, GENOTROPIN is prescribed for growth hormone deficiency (GHD) that started either in childhood or as an adult. Your doctor should do tests to be sure you have GHD, as appropriate.
Contraindications
Growth hormone should not be used to increase height in children after the growth plates have closed.

Growth hormone should not be used in patients with diabetes who have certain types of eye problems called diabetic retinopathy.

Growth hormone should not be used in patients with cancer or who are being treated for cancer. Growth hormone deficiency can be caused by brain tumors. So, the presence of these brain tumors should be ruled out before treatment is started. Growth hormone should not be used if it is shown that a previous brain tumor has come back or is getting larger.

Growth hormone should not be used in patients who are critically ill because of surgery, trauma, or respiratory failure.

Growth hormone should not be used in children with Prader-Willi syndrome who are very overweight or have severe breathing problems.

Other Safety Information
The dose of diabetes medicines may need to be adjusted during growth hormone treatment. Patients should be watched carefully if growth hormone is given along with glucocorticoid therapy and/or other drugs that are processed by the body in the same way.

Treatment with growth hormone may increase the risk of a new tumor, particularly certain benign brain tumors, in childhood cancer survivors. This risk may be higher in patients who were treated with cranial radiation.

A small number of patients treated with growth hormone have had increased pressure in the brain. This can cause headaches and problems with vision. Treatment should be stopped and reassessed in these patients. Patients with Turner syndrome, Prader-Willi syndrome, and chronic renal insufficiency may be at higher risk of developing increased pressure in the brain.

Thyroid function should be checked regularly during growth hormone therapy. Thyroid hormone replacement therapy should be started or adjusted if needed.

Patients treated with growth hormone should be checked regularly if they are receiving standard hormone replacement therapy to treat a lack of more than one hormone.

In children experiencing rapid growth, curvature of the spine may develop or worsen. This is also called scoliosis.

In children experiencing rapid growth, limping, or hip or knee pain may occur.

GENOTROPIN should only be used during pregnancy if clearly needed. It should be used with caution in nursing mothers because it is not known whether growth hormone is present in human milk.

Terms of Use Agreement
The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a health care provider. All decisions regarding patient care must be made with a health care provider, considering the unique characteristics of the patient.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

【外文名】Saizen，Norditropin，Genotropin，Norditropin，DNA-rhGH

【药理作用】为DNA重组技术生产的人体生长激素，是促进生长的机制之一，能刺激IGF-1和蛋白质合成，促进骨骼和体细胞的生长，利于脂肪分解和蛋白质合成，使肌肉增加，脂肪减少。

【适应症】用于内源性生长激素分泌不足或先天性性腺发育不全(特纳综合征)所引起的生长发育障碍，青春期前慢性肾功能不全所引起的生长发育障碍，成人生长激素不足的替代疗法(用于心功能不全等)。

【注意点】

1.配制药液时不可振荡，以免变性.

2.每周剂量分7天皮下注射，注射部位应更换，如有一天漏注，则第二天不必倍量补注。

3.糖尿病、妊娠、乳母慎用 。

4.恶性肿瘤术后，对本品过敏者，各种活动性恶性肿瘤禁用。5.不良反应可能会有甲状腺功能减退，液体潴留、伴周围水肿，曾有少数良性颅内高压病例的报告。

【用量用法】成人：生长激素不足：0.125iu/(kg.周)。先天性子宫发育不全：1iu/(kg.周)，以上剂量均分作7天皮下注射。

【规格】针剂：4iu，10iu，12iu，16iu。

原产地英文商品名:	Genotropin -0.6MGx7Cartridges/Box
原产地英文药品名:	somatropin [rDNA origin] for injection
原产地英文化合物名称:	Recombinant Human Growth Hormone
中文参考商品译名:	健豪宁 7支x0.6毫克/盒
中文参考药品译名:	注射用基因重组人类生长激素
中文参考化合物名称:	基因重组人类生长激素
临床试验期:	完成
中文适应病症参考翻译1:	儿童生长激素缺乏症 (GHD)
中文适应病症参考翻译2:	小于胎龄儿 (SGA)
中文适应病症参考翻译3:	普拉德-威利症候群 (PWS)
中文适应病症参考翻译4:	女孩Turner综合征(TS)、先天性卵巢发育不全
中文适应病症参考翻译5:	成人生长激素缺乏症 (aGHD)
生产厂家中文参考译名:	Pfizer Inc.
生产厂家英文名:	美国辉瑞