英文药名: Norditropin Simplexx Injection
中文药名: 诺德欣注射液(诺和诺德)
生产厂家: Novo Nordisk Pharmaceuticals
药品简介
适应症: 生长激素分泌不足
用药须知
1.开瓶前请保存在2- 8℃ 以下，不可冷冻
2.开瓶后可保存在25℃ 以下三周或2- 8℃ 以下四周
警语: 皮下注射，请规律的更换注射部位
Generic Name for NORDITROPIN
Somatropin (rDNA origin) 5mg, 15mg; per 1.5mL cartridge; soln for SC inj; for use only with corresponding color-coded NordiPen.
Legal Classification:
Rx
Pharmacological Class for NORDITROPIN
Growth hormone (GH).
Manufacturer of NORDITROPIN
Novo Nordisk
Indications for NORDITROPIN
Growth failure in children due to inadequate endogenous GH secretion. Children with short stature associated with Noonan or Turner syndrome. Children with short stature born small for gestational age (SGA) with no catch-up growth by age 2–4yrs. Adults with childhood-onset or adult-onset GH deficiency.
Adult dose for NORDITROPIN
Inject SC; rotate sites. Weight-based: Initially up to max 0.004mg/kg per day; may increase after 6 weeks to max 0.016mg/kg per day. Non-weight based: approx. 0.2mg/day (range: 0.15–0.3mg/day), may increase gradually every 1–2 months by increments of approx. 0.1–0.2mg/day.
Children's dosing for NORDITROPIN
Inject SC; rotate sites. Individualize. GH deficient: 0.024–0.034mg/kg per day, 6–7 times/week. Short stature w. Noonan: up to 0.066mg/kg per day. Short stature w. Turner or SGA: up to 0.067mg/kg per day.
Also:
NORDITROPIN FLEXPRO PEN
NORDITROPIN NORDIFLEX PEN
Contraindications for NORDITROPIN
Acute critical illness. Acute respiratory failure. Closed epiphyses. Active malignancy or growing intracranial tumors. Diabetic retinopathy. Prader-Willi syndrome (severely obese or w. respiratory impairment); see literature.
Warnings/Precautions for NORDITROPIN
Monitor gait, thyroid function, glucose tolerance, for malignant transformation of skin lesions, and for intracranial hypertension (do baseline and periodic funduscopic exams). History of intracranial lesions: monitor for lesion progression or recurrence. Prader-Willi syndrome: evaluate baseline respiratory function; monitor weight and for respiratory infection. Discontinue if signs of upper airway obstruction or sleep apnea occurs. Diabetes. Hypothyroidism. Scoliosis. Turner syndrome: evaluate for ear disorders (eg, otitis media); monitor for cardiovascular disorders (eg, stroke, aortic aneurysm/dissection, hypertension). Pregnancy (Cat.C). Nursing mothers.
Interactions for NORDITROPIN
Antagonized by glucocorticoids. Antidiabetic medications may need to be adjusted. May affect CYP3A4 substrates. Women on oral estrogen: may need higher somatropin dose.
Adverse Reactions for NORDITROPIN
Headache, inj site reactions, localized muscle pain, weakness, hypothyroidism, mild hyperglycemia, glucosuria, arthralgia, myalgia, fluid retention, edema, elevated serum phosphate, antibody formation, pancreatitis; also children: slipped capital femoral epiphysis. Long-term overdose may cause gigantism and/or acromegaly.
How is NORDITROPIN supplied?
Cartridges 5mg, 15mg—1 (use w. NordiPen device)
FlexPro prefilled pen—1
NordiFlex prefilled pen—1
通用名称为NORDITROPIN
生长激素（rDNA来源）5毫克，15毫克，每1.5ml的墨盒; SC注射soln只能使用相应的颜色编码NordiPen。
法律分类：
接收
类药物为NORDITROPIN
生长激素（GH）。
制造商的NORDITROPIN
诺和诺德
主治为NORDITROPIN
生长障碍儿童因内源性生长激素分泌不足。儿童身材矮小努南或特纳综合征相关。没有2岁4yrs的生长追赶出生胎龄（SGA）的小身材矮小的儿童。成人与儿童的发病或成人发病生长激素缺乏症。
成人剂量为NORDITROPIN
注入资深大律师旋转网站。重量为基础的：起初高达最大每天0.004mg/kg; 6周后增加至最大每天0.016mg/kg。基于不重：约。 0.2mg/day（范围0.15-0.3mg/day），每1-2个月可能会逐渐增加，增量约。 0.1-0.2mg/day。
儿童剂量为NORDITROPIN
注入资深大律师旋转网站。个性化。生长激素缺乏：0.024-0.034mg/kg，每天6-7次/周。短身材瓦特努南：高达每一天0.066mg/kg。短身材瓦特特纳或SGA：高达每一天0.067mg/kg。
另外：
NORDITROPIN FLEXPRO笔
NORDITROPIN NORDIFLEX笔
禁忌症为NORDITROPIN
急危重症。急性呼吸衰竭。封闭骨骺。主动恶性肿瘤或颅内肿瘤增长。糖尿病视网膜病变。 Prader - Willi综合征（严重肥胖或瓦特呼吸障碍）;文学。
为NORDITROPIN警告/注意事项
监视器的步态，甲状腺功能，糖耐量，皮损恶变，颅内压增高（基线和定期funduscopic考试）。历史颅内占位性病变：病变的进展或复发的监测。 Prader - Willi综合征：评估基准呼吸功能;显示器的重量和呼吸道感染。停止，如果发生上呼吸道阻塞或睡眠呼吸暂停的迹象。糖尿病。甲状腺功能减退。脊柱侧弯。特纳综合征：耳症的评估（如中耳炎）;监测心血管疾病（如中风，主动脉瘤/夹层，高血压）。怀孕（Cat.C）。哺乳的母亲。
为NORDITROPIN的相互作用
拮抗糖皮质激素。降糖药物可能需要调整。可能会影响CYP3A4的底物。口服雌激素的妇女：可能需要较高的生长激素剂量。
NORDITROPIN的不良反应
头痛，注射部位反应，局部肌肉疼痛，乏力，甲状腺功能减退，轻度高血糖，糖尿，关节痛，肌肉痛，水肿，水肿，血磷升高，抗体的形成，胰腺炎;也是儿童：下跌股骨头骨骺。长期过量可能会导致巨人症和/或肢端肥大症。
如何NORDITROPIN提供？
墨盒毫克，15毫克，1（使用瓦特NordiPen设备）
FlexPro预充笔- 1
NordiFlex预充笔- 1