脂类调节剂 --- Lovaza
“Lovaza”是一种特别的鱼油脂类调节剂，葛兰素史克药厂研发，目前被美国食品药品管理局（FDA）唯一批准为饮食辅助药物以降低成年患者的甘油三酸脂（³ 500 mg/dL）水平。Lovaza 每胶囊1克，含有 465 mg EPA，375 mg DHA，折算成900 mg omega-3脂肪酸乙酯 。此外，还含4 mg α-tocopherol，甘油，明胶和纯净水。

用途（适应症）：和低脂饮食一起用于降低高甘油三脂血症。Lovaza对心血管病的发病率和死亡率的影响尚无结论。还没有证明，使用Lovaza可预防心脏病发作或中风。

用法：使用Lovaza之前及之中应采取降脂饮食。本药应和低脂、低胆固醇饮食一起用于降低高甘油三脂血症。

贮存：25°C，短期内允许15° to 30°C。不能冰冻。

禁忌症：对其成分过敏者。

副作用：胃部不适，打嗝，感冒症状，背痛，皮疹，口内异味。如果这些反应持续或加重，应告知医师；如果发生严重的副作用：易出血，黑便，呕出咖啡色物，应尽快告知医师。严重的过敏反应有：皮疹，痒，肿，头晕眼花，呼吸困难。

注意事项：应把过敏史，对鱼或大豆等过敏告诉医师。孕妇只有明确适应症时使用。目前还不清楚该药是否进入乳汁中。

下列情况应告知医师：每日饮酒2杯以上；糖尿病；甲状腺疾病；肝病；鱼过敏；怀孕或准备怀孕；哺乳。告诉医师用药情况，包括维生素和草药。特别是阿司匹林，华法林等抗凝药。以避免危险。

Lovaza

Generic Name: omega-3 polyunsaturated fatty acids (oh MAY ga 3 POL ee un SAT yoo ray ted FAT ee AS ids)

Brand Names: Animi-3, EPA Fish Oil, Fish Oil, Icar Prenatal Essential Omega-3, Lovaza, Marine Lipid Concentrate, MaxEPA, MaxiTears Dry Eye Formula, MaxiVision Omega-3 Formula, Mi-Omega, Mi-Omega NF, Omacor, Omega-500, Proepa, Sea-Omega, Sea-Omega 30, Sea-Omega 70, TheraTears Nutrition

What is Lovaza (omega-3 polyunsaturated fatty acids)?
Omega-3 polyunsaturated fatty acids are found in oil from certain types of fish, vegetables, and other plant sources. These fatty acids are not made by the body and must be consumed in the diet. Omega-3 polyunsaturated fatty acids work by lowering the body's production of triglycerides. High levels of triglycerides can lead to coronary artery disease, heart disease, and stroke.

Omega-3 polyunsaturated fatty acids are used together with diet and exercise to help lower triglyceride levels in the blood.

Omega-3 polyunsaturated fatty acids may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Lovaza (omega-3 polyunsaturated fatty acids)?
Take this medication exactly as directed on the label, or as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended.

Swallow the omega-3 polyunsaturated capsule whole. Do not puncture or open the capsule.
This medication is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

If you miss a dose, use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

There may be other drugs that can affect omega-3 polyunsaturated fatty acids. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Stop using this medication and get emergency medical help if you think you have used too much medicine, or if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Less serious side effects are more likely, and you may have none at all. Talk to your doctor about any side effect that seems unusual or is especially bothersome.

What should I discuss with my health care provider before taking Lovaza (omega-3 polyunsaturated fatty acids)?
Do not use this medication if you are allergic to fish or soybeans.
Ask a doctor or pharmacist about using this medicine if you have:
diabetes;
liver disease;
a pancreas disorder;
underactive thyroid;
if you drink more than 2 alcoholic beverages per day.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before you take omega-3 polyunsaturated fatty acids, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether omega-3 polyunsaturated fatty acids pass into breast milk or if this could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to anyone under 18 years old.

How should I take Lovaza (omega-3 polyunsaturated fatty acids)?
Take this medication exactly as directed on the label, or as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended.

Swallow the omega-3 polyunsaturated capsule whole. Do not puncture or open the capsule. This medication works best if you take it with food.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

This medication is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store this medication at room temperature away from moisture and heat. Do not freeze.

What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
An overdose of omega-3 polyunsaturated fatty acids is not expected to produce life-threatening symptoms.

What should I avoid while taking Lovaza (omega-3 polyunsaturated fatty acids)?
Avoid eating foods that are high in fat or cholesterol. This medication will not be as effective in lowering your triglycerides if you do not follow the diet plan recommended by your doctor.

Avoid drinking alcohol. It can increase triglycerides and may make your condition worse.

Lovaza (omega-3 polyunsaturated fatty acids) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:
fever, chills, body aches, flu symptoms;
chest pain; or
uneven heartbeats.

Less serious side effects may include:
back pain;
unusual or unpleasant taste in your mouth;
upset stomach, belching; or
mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lovaza (omega-3 polyunsaturated fatty acids)?
Before taking this medication, tell your doctor if you are using any of the following drugs:
estrogens (birth control pills or hormone replacement);
a blood thinner such as warfarin (Coumadin);
a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Blocadren), and others; or
a diuretic (water pill) such as chlorothiazide (Diuril), hydrochlorothiazide (HydroDIURIL, Microzide), chlorthalidone (Hygroton, Thalitone), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), and others.

This list is not complete and there may be other drugs that can interact with omega-3 polyunsaturated fatty acids. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Where can I get more information?
Your pharmacist can provide more information about omega-3 polyunsaturated fatty acids.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.