抑郁症和伴随的焦虑症状往往是大脑内化学物质失去平衡的结果。许多种因素可以触发这种失衡。怡诺思缓释胶囊是一种全新的口服药物，是一种5-羟色胺和去甲肾上腺素双重再摄取抑制剂，即同时增加5-羟色胺和去甲肾上腺素的水平。用于治疗抑郁症和广泛性焦虑症。它能有效抑制5-羟色胺（5-HT）和去甲肾上腺素（NE）的再摄取。
研究证明，5-羟色胺和去甲肾上腺素是神经细胞用于彼此联络的两种重要化学物质。这些名为神经递质的化学物质在专心、注意和攻击中起作用。5-羟色胺和去甲肾上腺素缺乏被认为在抑郁症和广泛性焦虑症中起重要作用。某些药物通过在大脑中被称为为抑制再摄取的机制增加5-羟色胺和去甲肾上腺素水平，因而有助于治疗抑郁症和广泛性焦虑症。
怡诺思（盐酸文拉法辛缓释胶囊）适用于治疗抑郁症、伴有焦虑症状的抑郁症和广泛性焦虑症（GAD）。怡诺思用于儿科病人的安全性和疗效尚未确定。
优点：
研究提示，治疗抑郁症时，作用于两种化学物质的药物（如怡诺思）可能比只作用于其中一种化学物质的药物效果要好。这是因为，对于抑郁症患者，还不清楚到底是针对哪种类型化学物质（5-羟色胺还是去甲肾上腺素）的治疗效果最好。增加两种化学物质可以帮助更多的病人恢复正常。
怡诺思的疗效在最近两项研究中得到证实。这两项研究比较了用怡诺思和氟西汀治疗时，病人达到临床治愈（即完全没有症状）的比例。结果发现，怡诺思治疗组病人达到临床治愈（完全没有症状）的比例高于氟西汀治疗组。
怡诺思是第一个同时适用于抑郁症和广泛性焦虑症的抗抑郁药。也就是说，每天服用一次怡诺思，可以治疗抑郁症、广泛性焦虑症或两种疾病并存的病人。通过服用这样一种可以同时减轻广泛性焦虑症和抑郁症多种重叠症状的药物，就会有更多的病人会达到临床治愈（完全没有症状），而不只是治疗有效（即症状减轻一半以上）。

文怡诺思缓释胶囊说明
【中文名称】： 怡诺思缓释胶囊
【简写拼音】： YNSHSJN
【英文名称】： Venlafaxine HCl
【所属类别】： 抗抑郁药
【别名】怡诺思缓释胶囊 , 盐酸文拉法辛 , 文拉法辛
【外文名】Venlafaxine HCl, Efexor XR
【适应症】各种类型抑郁症，包括伴有焦虑的抑郁症及广泛性焦虑症。
【不良反应】常见的不良反应为 ：胃肠道不适(恶心、口干、厌食、便秘和呕吐)、中枢神经系统异常(眩晕、嗜睡、梦境怪异、失眠和紧张)、视觉异常、打哈欠、出汗和性功能异常(阳痿、射精异常、性欲降低)。偶见不良反应为 ：无力、气胀、震颤、激动、腹泻、鼻炎。不良反应多在治疗的初始阶段发生，随着治疗的进行，这些症状逐渐减轻。文拉法辛没有明显的药物依赖倾向。
【用法用量】起始推荐剂量为75 mg/天，每天1次。如有必要，可递增剂量至最大为225 mg/天(间隔时间不少于4天。每次增加75 mg/ 天)。肝功能损伤病人的起始剂量降低50%，个别病人需进行剂量个体化。肾功能损伤病人，每天给药总量降低25- 50%。老年病人按个体化给药，增加用药剂量时应格外注意。如果用文拉法辛治疗6周以上，建议逐渐停药，所需的时间不少于2周。 用药须知本品缓释胶囊应在每天相同的时间与食物同时服用，每天1次，用水送服。注意不得将其弄碎、嚼碎后服用或化在水中服用。
【注意事项】对本品过敏及正在服用单胺氧化酶抑制剂的患者禁用本品。 某些病人服用文拉法辛后会出现血压持续高，对服用本品的病人，应定期监测血压。若出现血压持续升高，应减小剂量或停药。
【规格】75 mg本药为桃色胶囊，囊体上印有"75"，囊帽上印有"W"。150 mg本药为深桔色胶囊，囊体上印有"150"，囊帽上印有"W"。
【不良反应防治】
(1)对本品过敏者禁用。闭角型青光眼、癫痫患者慎用。
(2)严重心脏疾患、高血压、甲状腺疾病、血液病患者慎用。
(3)肝肾功能不全者慎用或减少用量。
(4)用药过程中应监测血压，血压升高应减量或停药。
(5)停用时应逐渐减少剂量，已应用本品6周或更长时间者，应在2周内逐渐减量。
(6)患者出现有转向躁狂发作倾向时应立即停药。
(7)用药期间不宜驾驶车辆、操作机械或高空作业。

Know the Facts
Effexor XR® (venlafaxine hydrochloride—or HCl) is a prescription antidepressant proven to treat the symptoms of depression and three anxiety disorders: generalized anxiety disorder (GAD), panic disorder (PD), and social anxiety disorder (SAD).
For more than 12 years, Effexor® and Effexor XR have been used by many people to help manage the symptoms of depression and to help keep them from coming back.
How Does Effexor XR Work?
Effexor XR is believed to treat depression and anxiety symptoms by affecting the levels of two naturally occurring chemicals in the brain — serotonin and norepinephrine. It is believed that correcting an imbalance of these two chemicals may help relieve symptoms. Because Effexor XR affects these two chemicals, it is known as an SNRI, or serotonin-norepinephrine reuptake inhibitor.
depression treatment
The goal of depression treatment is to relieve symptoms and keep them from coming back. The American Psychiatric Association (APA) describes achieving symptom relief as remission. This means feeling virtually free of symptoms of depression and getting back to doing the things you once enjoyed.
Achieving remission is important for restoring the quality of life at work and at home that you once experienced before depression. But it is also important medically: research indicates that people who have unresolved symptoms of depression after the first phase of treatment (the acute phase) may be three times as likely to experience a relapse — or have their depression return.
Unresolved symptoms can have an impact on the course of your condition. Knowing this, you shouldn't settle for some symptom relief. You deserve to reach the goal of remission.
depression
Depression is a serious medical condition that affects approximately 12 million U.S. adults. Depression is described by the American Psychiatric Association as a "mood disorder," and one of the most common symptoms is a constant feeling of sadness.
Depression can make you lose interest in the things you love or drain you of your normal level of energy. It can affect your appetite and your sleeping habits — and create feelings of hopelessness and worthlessness. These feelings may make you feel as though you will never be free from your symptoms — and don't even have the energy to try.
Fortunately, depression is treatable. You can work with your doctor to find a treatment option that may work well for you. The first goal of treatment is remission — full relief from symptoms. Once you achieve remission, the goal is to sustain it.
anxiety disorders
For most people, anxiety is a normal response to occasional stress. It's our body's way of preparing us to respond to a challenge. But for the more than 18.1 million U.S. adults suffering from an anxiety disorder, extreme and uncontrollable levels of worry and tension are a way of life.
Many of these people may experience disabling emotional and physical symptoms from one or more anxiety disorders. They often develop depression at some point, too.