英文药名：EFFEXOR SR CAPSULES（Venlafaxine Hydrochloride） 中文药名：盐酸文拉法辛SR胶囊 生产厂家：辉瑞公司 イフェクサーSRカプセル37.5mg／イフェクサーSRカプセル75mg 治疗类别名称 血清素去甲肾上腺素重摄取抑制剂 上市批准日期：2015年12月 商標名 EFFEXOR SR CAPSULES 通用名：盐酸文拉法辛（Venlafaxine Hydrochloride） 治疗病症：抑郁症 用法与用量： 通常情况下，为成人37.5毫克1-一天，初始剂量为文拉法辛，口头一顿饭一天一次给药后每天75毫克的超过一个星期。此外，年龄，将适当地增加或不超过每日225毫克根据状况的范围内降低时，增加由75毫克为1周以上的时间间隔的每日剂量进行。 包装规格 EFFEXOR SR胶囊 37.5毫克：100,500胶囊（PTP），100粒（瓶） 75毫克：100,500胶囊（PTP），100粒（瓶） 制造和销售 辉瑞公司日本 完整处方资料附件：http://www.info.pmda.go.jp/go/pack/1179055N1021_1_03/ EFFEXOR SR CAPSULES 37.5mg（イフェクサーSRカプセル37.5mg） Brand name : EFFEXOR SR CAPSULES 37.5mg 　Active ingredient: Venlafaxine hydrochloride 　Dosage form: pale gray/pale red capsule, major axis: 15.9 mm, minor axis: 5.8 mm 　Print on wrapping: EFFEXOR SR 37.5mg, イフェクサーSR, 37.5, イフェクサーSR37.5mg, W37.5 EFFEXOR SR CAPSULES 75mg（イフェクサーSRカプセル75mg） Brand name : EFFEXOR SR CAPSULES 75mg 　Active ingredient: Venlafaxine hydrochloride 　Dosage form: pale red/pale red capsule, major axis: 19.4 mm, minor axis: 6.9 mm 　Print on wrapping: EFFEXOR SR 75mg, イフェクサーSR, 75, イフェクサーSR75mg, W75 Effects of this medicine This medicine has the antidepressant effect by selectively inhibiting the reuptake of neurotransmitters (serotonin, noradrenaline) in the brain to increase the level of neurotransmitters at the synaptic cleft. It is usually used to treat depression/depressed state. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have: liver dysfunction or renal dysfunction. If you are on dialysis. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •In general, for adults, start with 1 capsule (37.5 mg of venlafaxine) at a time, once a day. After a week, take 2 capsules (75 mg) at a time after meal, once a day. The dosage may be adjusted up to 6 capsules (225 mg) per day according to the age or symptoms. The dosage may be increased by 2 capsules (75 mg) at a day, with an interval of at least one week. Strictly follow the instructions. •This medicine is sustained release preparation, do not crush or grind capsule contents and take it without chewing. •If you miss a dose and remember it within one day, take the missed dose as soon as possible. You should never take two doses at one time. •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Sudden discontinuation of this medicine may cause adverse symptoms (hypomanic, anxiety, agitation, nervousness, confusion, sleep disorder, etc.). Precautions while taking this medicine •This medicine may cause sleepiness and dizziness. Do not operate dangerous machinery, such as driving a car. •Avoid alcohol during medication, since alcohol may intensify medicinal or medical effects. •Pay attention that any foods containing St. John's wort (a kind of herb) may intensify serotonin action. •This medicine may cause worsening symptoms of the disease, suicidal thoughts/suicide attempt and harming others, but these causal relationships are unknown. If any of these signs occur, consult with your doctor/pharmacist without stopping your medication. Possible adverse reactions to this medicine The most commonly reported adverse reactions include nausea, stomach discomfort (abdominal pain, abdominal enlarged feeling, constipation, etc.), somnolence, dizziness, dry mouth and headache. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •anxiety, confusion, sweat [serotonin syndrome] •akinetic mutism, muscle stiffness, swallowing difficulty [neuroleptic malignant syndrome] •muscle spasmodically contracting [convulsion] •respiratory distress, wheezing, angioedema [anaphylaxis] •fever, dry cough, respiratory distress [interstitial lung disorder] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of reach of children. Store away from direct sunlight, heat and moisture. •Discard the remainder. Do not store them. If you dispose of unused medicines, ask the pharmacist and the medical institution how to discard them. •[To family members] This medicine may cause change in patient's behavior such as suicide, tendency to excite, acting aggressive and change in mental or physical condition due to slight irritation, and worsening of the underlying disease such as depression. Receive an adequate explanation from the doctor for full understanding these risks and observe change in the patient's condition. If family members notice any of these conditions, contact the doctor. Pfizer Pharmaceuticals Inc.Internal Published: 11/2015 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.