英文药名：RESPLEN Tablet（Eprazinone hydrochloride）

中文药名：盐酸依普拉酮片

生产厂家：中外制药

レスプレン錠5mg／レスプレン錠20mg／レスプレン錠30mg

治疗类别名称
镇咳・气道粘液溶解剂
商標名
RESPLEN
一般名
エプラジノン塩酸塩（Eprazinone Hydrochloride）(JAN）
化学名
1‐(2‐Phenyl‐2‐ethoxy)ethyl‐4‐(2‐enzoyl)propylpiperazine dihydrochloride
構造式

分子式
C24H32N2O2・2HCl
分子量
453.45
性　状
白色结晶性粉末，不臭，味微苦，微麻木的舌头。
微溶于热水，微溶于水或乙酸（100），甲醇，乙酸酐或乙醇（95）中微溶，并在乙醚中几乎不溶。
熔点
约197℃（分解）
适应病症
适用于急 慢性支气管炎 哮喘 肺炎 肺结核 肺气肿等疾病的镇咳和祛痰 
用法用量
成年人每日剂量：口服三次60-90毫克。
在30毫克片的情况
成人每日口服三次，每次口服一片（30毫克）。它是根据年龄和症状调整。
口服给药三倍以下数额为每日剂量为年轻的孩子Epurajinon盐酸盐。
3岁以上且小于6岁
20-30毫克
10岁以下的超过6岁
30-45毫克
用法，用量的表
口服给药参考以下

成人１日量 （分３)	幼・小児1日量(分3)： 3歳以上6歳未満	幼・小児1日量(分3)： 6歳以上10歳未満
５mg錠	12～18錠	４～６錠	６～９錠
20mg錠	３～４錠	－	－
30mg錠	３錠	－	－

药效药理
1. 去痰作用
(1) 酸性粘多糖纤维·丰富的DNA纤溶作用
从慢性呼吸系统疾病患者增加了Epurajinon盐酸收集痰，细胞学检查，结果，改变·富DNA的纤维，由动作强粘液被膨化-横断的酸性粘多糖纤维的性能它表现出裂解活性（体外）。
(2) 痰一致性降血脂作用
加入盐酸Epurajinon在体外从慢性呼吸道疾病患者，旋转粘度计法，奥氏粘度计，赫希变种收集痰，在斜率法调查的结果，清楚地表明一致性的影响降低这是。
(3) 气道内分泌液增加作用
通过使用鼠标检查上气道分泌物Epurajinon盐酸的作用的结果，明确气道分泌物增加作用，观察到在给药后3小时后，即使在气道诱导病症分泌物增加。
2. 鎮咳作用
这表明豚鼠，猫，电刺激与狗等，机械性刺激，镇咳作用不相上下，在化学刺激实验可待因酸水合物。
包装规格
*片剂
5毫克：500粒（PTP）

20毫克：500粒（PTP）1000片（PTP，瓶装）

30毫克：500粒（PTP）1000片（PTP）

制造厂商
中外制药有限公司
RESPLEN Tablet 5mg（レスプレン錠5mg） 
Brand name : RESPLEN Tablet 5mg
　Active ingredient: Eprazinone hydrochloride
　Dosage form: white tablet (φ: 5.1mm, thickness: 2.4mm)
　Print on wrapping: レスプレン5
RESPLEN Tablet 20mg（レスプレン錠20mg）
Brand name : RESPLEN Tablet 20mg
　Active ingredient: Eprazinone hydrochloride
　Dosage form: white tablet (φ: 8.1mm, thickness: 4.3mm)
　Print on wrapping: レスプレン20
RESPLEN Tablet 30mg（レスプレン錠30mg）
Brand name : RESPLEN Tablet 30mg
　Active ingredient: Eprazinone hydrochloride
　Dosage form: white tablet (φ: 8.1mm, thickness: 4.3mm)
　Print on wrapping: レスプレン30
Effects of this medicine
This medicine works on central nerve and suppresses the excitation of cough center to stop coughing. Also, it increases bronchial secretion to decrease the viscosity of phlegm, consequently, to make it easy for a patient to cough out phlegm. It is usually used to treat symptoms of cough and phlegm caused by respiratory diseases such as cold, upper respiratory infection, bronchitis, and pneumonia. 
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reaction (itch, rash etc.) to any medicine.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take 4-6 tablets (20-30mg of the active ingredient) at a time, 3 times a day. It should be adjusted according to your disease, age and symptoms. Toddlers/children should take the following amount of this medicine in 3 divided doses a day; for children aged 3 or over but under 6: 4-6 tablets (20-30mg of the active ingredient), for children aged 6 or over but under 10: 6-9 tablets (30-45mg of the active ingredient).
Strictly follow the instructions.
•This medicine is specially designed to avoid bitterness. Take it without chewing, otherwise you will note bitterness.
•If you missed a dose, take the missed dose as soon as possible and continue your regular dosing schedule. However, you should never take two doses at one time.
•If you accidentally took more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include loss of appetite, nausea/vomiting, stomach discomfort, diarrhea (including loose stool) and symptom of irritation. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store in a covered container, at room temperature (1-30℃). Keep away from direct sunlight and moisture.
•Discard the remainder. Do not store them. Ask the pharmacist how to discard.
Chugai Pharmaceutical Co., Ltd.Internal
Revised: 5/2007
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/2249001F1030_1_06/