【药品名称】
药品名（中）：长春瑞滨注射液
汉语拼音：Changchunruibin Zhusheye
英文名：Vinorelbine Injection
剂型：注射剂
【主要成份】长春瑞宾。
【性状】本品为无色至微黄色的澄明液体。
【药理毒性】本品主要是与微管蛋白结合，使细胞在有丝分裂过程中微管形成障碍，为周期特异药物，作用近似长春新碱。对轴突微管也有亲合力，可引起神经毒性，但较长春新碱要轻。
【药代动力学】
【适应症】主要用于非小细胞肺癌、乳腺癌、卵巢癌、淋巴瘤等。
【用法用量】静滴，一般为25～30mg?/m2，用生理盐水125ml稀释，每周1次，连续4～6次为一疗程。
【不良反应】骨髓抑制较明显，主要是白细胞减少，多在7天内恢复。也见有血小板减少和贫血。神经毒性主要表现为腱反射减低及便秘，罕见麻痹性肠梗阻。此外尚有指（趾）麻木、恶心、呕吐和脱发。
【禁忌】孕妇、哺乳期妇女、严重肝功能不全者禁用。
【注意事项】1.此药对静脉有刺激性，应避免漏于血管外，注药完毕后应再给100～250ml生理盐水冲洗静脉。2.避免沾染眼球，以免造成角膜溃疡。3.本品用生理盐水或5％葡萄糖注射液稀释后在密封玻璃瓶中室温下保存24小时有效。
【孕妇和哺乳期妇女用药】
【儿童用药】
【老年患者用药】
【药物相互作用】
【药物过量】
【规格】10毫克/1毫升/支
【贮藏】遮光，密闭，在2～8oC保存。
【包装】西林瓶包装
【有效期】24个月
【进口药品注册证号】
【进口药品分装批准文号】
【生产企业】AvenueduBearn64320IDRON，France(法国)

Navelbine ® (vinorelbine)

Navelbine® is a chemotherapy drug that has been traditionally used for a number of different kinds of cancer, including breast cancer and non-small-cell lung cancer.  When used to treat mesothelioma, studies have shown that this drug produces less crippling side effects than other standard chemo drugs, such as cisplatin. 

In clinical trials of the drug, vinorelbine was shown not only to enhance quality of life for meso patients, but nearly 25% of the patients responded to the treatment, while the disease was stabilized for a time in nearly half of the individuals participating in the studies.  Other chemotherapy drugs have had less than a 20% success rate among patients with malignant mesothelioma.

Treatment with Navelbine ®

If your oncologist determines that vinorelbine is the right drug for treatment of your unresectable malignant mesothelioma, you’ll want to know more about treatment with this drug. 

• Navelbine ® can be administered in a few different ways.  It may be injected intravenously through a cannula inserted in the vein.  It also may be given through a central line, inserted near the collarbone or in the crook of the arm.  In addition, this drug is available in capsule form, but patients must adhere to a strict schedule.
• Treatment is administered on an outpatient basis.
• Your doctor will determine how many cycles of treatment are appropriate for your individual case.

Side Effects

Everyone reacts differently to chemotherapy medications and Navelbine ® does indeed cause fewer side effects than many older chemo drugs.  You may, however, experience some of the following.

• Lowered resistance to infection caused by reduction in white blood cells.  This may be indicated by a fever or simply “not feeling well.”
• Bruising or bleeding caused by a reduction in platelets.
• Anemia
• Constipation
• Diarrhea
• Nausea and vomiting
• Numbness
• Pain at injection area
• Hair loss (uncommon)
• Leaking around the injection area (uncommon)

Report any side effects to your doctor or nurse immediately to avoid complications.