【药品名称】头孢替坦二钠（Cefotetan Disodium ）
【别名】 头孢替坦 ,头孢替坦二钠,双硫唑甲氧头孢菌素
【外文名】Cefotetan Disodium,Cefotetan ,Cefotan
【药理作用】
为头霉素类，作用与第三代头孢菌素近似。对产酶革兰阴性菌和厌氧菌有好作用。 本品为半合成广谱头孢霉素。对革兰阴性菌的作用较第一、二代头孢菌素强。临床主要用于呼吸道、肺部感染、腹部感染、尿路感染、妇科感染及中耳炎等。
【适应症】
用于易感菌所致腹内、皮肤软组织感染和尿路、下呼吸道及妇产科等感染。
【用量用法】
深部肌注、静注或静滴：成人：每日１～６ｇ，等量分注，１２小时１次。成人常用量每１２小时用１～２ｇ。每日最大剂量以６ｇ为限。儿童４０～６０ｍｇ／ｋｇ·ｄ，病情严重者可增至１００ｍｇ／ｋｇ·ｄ，分２～３次。
【副作用】 1. 别有皮疹、瘙痒、药热等皮肤过敏反应。 2 .偶有血象改变、肝肾功能异常、腹泻等不良反应； 3. 罕有恶心、呕吐、休克等不良反应。
【注意事项】
1.过敏反应：皮疹、瘙痒、发热。 2.胃肠功能紊乱有腹泻、恶心、呕吐。 3.血象轻微改变及肝功能异常。 4.可致低凝血酶原症，有出血倾向。 5.禁用于对本品过敏者、乳儿、小儿及对利多卡因过敏者。 6. 慎用于对青霉素、头孢菌素类有过敏吏者及严重肾功能。
【规格】 注射剂：１ｇ（２ｇ、１０ｇ）。

【原产地英文商品名】CEFOTETAN 2GM/20ML/VIAL 10VIALS/BOX
【原产地英文药品名】CEFOTETAN DISODIUM
【生产厂家中文参考译名】APP Pharmaceuticals,LLC
【生产厂家英文名】APP Pharmaceuticals,LLC

Information on CEFOTETAN

Why is this medication prescribed?   
Cefotetan injection is used to treat infections of the lungs, skin, bones, joints, stomach area, blood, female reproductive tract, and urinary tract. Cefotetan injection is also used before surgery to prevent infections. Cefotetan injection is in a class of medications called cephalosporin antibiotics. It works by killing bacteria. Antibiotics will not work for colds, flu, or other viral infections.

How should this medicine be used?   
Cefotetan injection comes as a powder to be added to fluid and injected intravenously (into a vein) or it can be injected into a large muscle (such as your buttock). It is usually given one or two times a day. You may receive cefotetan injection in a hospital or you may administer the medication at home. If you are using cefotetan injection at home, use it at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cefotetan injection exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
You should begin to feel better during the first few days of treatment with cefotetan injection. If your symptoms do not improve or get worse, call your doctor.
Use cefotetan injection until you finish the prescription, even if you feel better. If you stop using cefotetan injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

What special precautions should I follow? 
Before using cefotetan injection,
tell your doctor and pharmacist if you are allergic to cefotetan injection; other cephalosporin antibiotics such as cefaclor, cefadroxil (Duricef),cefazolin (Ancef), cefdinir (Omnicef), cefditoren (Spectracef), cefepime (Maxipime), cefixime (Suprax), cefotaxime (Claforan), cefoxitin, cefpodoxime (Vantin), cefprozil (Cefzil), ceftazidime (Fortaz), ceftibuten (Cedax), ceftriaxone (Rocephin), cefuroxime (Ceftin, Zinacef), and cephalexin (Keflex); penicillins; or any other medications.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as amikacin, gentamicin, kanamycin, neomycin, streptomycin, and tobramycin; and anticoagulants ('blood thinners') such as warfarin (Coumadin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have or have ever had hemolytic anemia (condition where a low number of red blood cells occurs because the cells are being destroyed in the body). Your doctor may tell you not to use cefotetan injection.
tell your doctor if you have or have ever had cancer; gastrointestinal diseases such as colitis; or gallbladder, kidney, or liver disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking cefotetan injection, call your doctor.
remember you should not drink alcoholic beverages while using cefotetan injection and for 3 days after receiving cefotetan injection. Drinking alcohol during this time period may cause headache, fast heartbeat, sweating, and flushing (redness of the face).
What special dietary instructions should I follow?  

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Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?  
Cefotetan injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: nausea；diarrhea
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
shortness of breath；fast heartbeat；headache；dizziness；pale skin；confusion；extreme tiredness；severe diarrhea with watery or bloody stools (up to 2 months after your treatment)；fever；stomach pain；unusual bleeding or bruising；hives；skin rash；itching；difficulty breathing or swallowing；redness, pain, or swelling at the injection site

What storage conditions are needed for this medicine? 
If you will be injecting cefotetan injection at home, your healthcare provider will tell you where you should store it and how long you may keep it. Follow these directions carefully. Be sure to store cefotetan injection in the container it came in and out of reach of children. Throw away any medication that is outdated or no longer needed. Talk to your health care provider about the proper disposal of your medication.