头孢米诺钠　Cefminox Sodium（MEICELIN）
【药物名称】Cefminox sodium, MT-141, Alteporina, Tencef, Meicelin
【化学名】7beta-[2-[2(S)-Amino-2-carboxyethylthio]acetamido]-7alpha-methoxy-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid sodium salt
为头霉素衍生物，由半合成法制取，其作用性质与第三代头孢菌素相近，制成品为七水合物。
【产品分类】抗感染药\抗生素\其它β-内酰胺类\头霉素类
【性状】常用其钠盐，为白色或微黄白色结晶性粉末，溶于水，5％水溶液的pH为4.5～6.0。
【成分】为头霉素衍生物，由半合成法制取，其作用性质与第三代头孢菌素相近，制成品为七水合物。
【其他名称】美士灵, 氨羧甲氧头孢菌素钠, 注射用头孢米诺钠, 立键诺, 头孢米诺钠（无菌粉）, 迈诺
【英文其他名称】Meicelin, Cefminox Sodium for Injection, Meicilin, Melnox
【功能/功效】适用于治疗敏感菌所致的下列感染：
1.呼吸系统感染：扁桃体炎、扁桃体周围脓肿、支气管炎、细支气管炎、支气管扩张伴感染、慢性呼吸道疾患继发感染、肺炎、肺化脓症。
2.腹腔感染：胆囊炎、胆管炎、腹膜炎。 
【药理作用】对大肠杆菌、链球菌、克雷白杆菌、流感嗜血杆菌、拟杆菌等有抗菌作用。头霉素类有较强的抗?-内酰胺酶性能。本品尚对细菌壁中肽聚糖生成脂蛋白起防碍作用。脂蛋白结构为革兰阴性菌所特有，因此，本品对革兰阴性菌的作用较其他同类药物为强。
【注意事项】
1.偶可致过敏、休克，故对青霉素、其他头孢菌素过敏者应慎用。
2.可致肾损害，如血肌酐、血尿素氮值上升，少尿、蛋白尿等。 3.可致红细胞、白细胞、血小板的减少。
4.肝酶升高，血胆红素升高及黄疸等也可发生。
5.消化道反应有食欲不振、恶心、呕吐、腹泻等，菌群失常而致维生素缺乏和二重感染等也可发生。
6.其他参见头孢美唑。
【给药说明】
1.用药前宜进行皮试，皮试阳性者不能使用本药。
2.本药与氨茶碱、磷酸吡哆醛、维生素B★6★呈配伍禁忌。
3.用药期间及用药后1周内应避免饮酒。
本品静注，每1g药物用20ml注射用水，5%-10%葡萄糖液或等渗盐水溶解。滴注时，每1g药物溶于输液100-200ml中，滴注1-2小时。
【适应症】用于扁桃体、呼吸道、泌尿道、胆道、腹腔、子宫等部位感染，也可用于败血症。
【用法与用量】
成人
·常规剂量
·静脉给药
1.一般感染：一次1g，一日2次。静脉注射或静脉滴注。
2.败血症和重症感染：一日6g，分3-4次静脉注射或静脉滴注。
儿童
·常规剂量
·静脉给药 一次20mg/kg，一日3-4次。
【贮法】密闭、避光保存。
【禁忌】(1)对本药过敏者。(2)有青霉素过敏性休克史者。

A postmarketing surveillance of cefminox sodium (Meicelin, CMNX) for intravenous injection was conducted for about 4 years from August 1987 through June 1991, and 13,431 patients were followed up to evaluate the safety of the drug. The incidence of side-effects was 1.76%. By organ, the most frequently observed were hepatic and of the bile duct system (0.87%) followed by those on leukocytes and reticuloendothelial system (0.24%), skin and adnexa (0.24%) and digestive tract (0.16%) indicating a tendency similar to that of other injectable cephalosporins. The incidence of the side-effects among elderly patients (65 years old or older) was 2.12%, whereas among patients 64 years old or younger it was 1.58% with no significant differences between the two groups. No side-effects specific to the elderly were observed. Among children 15 years old or younger the incidence was 0.59%, which was lower than that for patients 16 years old or older (1.90%). Potential side-effects on pregnant women (n = 101) and their babies were also checked. No side-effects occurred among the 52 pregnant women evaluated and no abnormalities were detected in their babies who were followed up for up to 4 years. Cefminox is thus considered to be a highly safe cephalosporin antibiotic.

メイセリン静注用1g