【药品简介】
塔卡属于抗高血压药物，结合2种降血压药物：ACE抑制剂和钙通道阻滞剂: 群多普利和维拉帕米。群多普利可以舒张血管，提高心脏工作的效率。维拉帕米属于一种叫做钙通道阻滞剂类药物。维拉帕米可以舒张血管和维持心脏节律正常化。
塔尔卡也被用来减轻和控制心绞痛（胸痛）。
医生将确定最佳的剂量来控制你的症状。通常的推荐剂量为1片1天1次或2次同食物一起服用。不要压碎或咀嚼。
塔卡的使用过程中可能的副作用：过敏反应,腹痛,便秘,咳嗽,头晕,头痛,心跳不规则,上呼吸道感染,背痛,支气管炎等。
【规格】
群多普利/盐酸维拉帕米缓释片：群多普利为速释成份，盐酸维拉帕米为缓释成份，规格：2/180；1/240；2/240；4/240
【药理及毒理】
本品药理毒理资料全，不需做毒理试验。
【适应症】
1.适用于治疗高血压病。（可单独服用，也可与其它降压药物联合使用如氢氯噻嗪。）
2. 适用于治疗心力衰竭或左心肌功能不全导致的心肌梗塞。
【用法用量】
1.用于治疗高血压病：
口服，每次2～4mg，每日1次。建议初剂量每日1mg或2mg。建议间隔周调整一次剂量，每日不能超过* mg。
2.用于治疗心力衰竭或左心肌功能不全导致的心肌梗塞：
建议开始用量每次1mg，每日一次。可达到每天4 mg，如果4 mg也不能控制，可以继续加大剂量治疗。
【品种特点】
本品口服吸收迅速，且不受饮食因素的影响，连服4 d即达血浆稳态浓度。几乎全部药物在7 d内被排泄到体外。具有高度亲脂性，易穿透到机体各组织尤其是心肌和血管壁，和其他ACEI药物如雷米普利(ramipril)、雷米普利拉(rimiprilat)、培哚普利(perindopril)、依那普利拉、卡托普利相比较，群多普利是其中最具亲脂性。
经实验证明，本品反复给药无蓄积作用 ，因此老年高血压病人使用本品无需改变剂量。
群多普利与盐酸维拉帕米合并用药对严重的高血压或靶器官损坏的高血压患者尤为有利。本复方制剂是将苯烷基胺钙拮抗剂和血管紧张素转化酶抑制剂(ACEI)的作用结合在一起。该复方制剂可作为早期高血压的首选治疗，而且使用复方制剂可增加病人的依从性。

【原产地英文商品名】TARKA 24HR SA TABLET (1/240)mg/tab 100tabs/box
【原产地英文药品名】TRANDOLAPRIL/VERAPAMIL HCL
【中文参考药品译名】群多普利/盐酸维拉帕米
【生产厂家中文参考译名】雅培
【生产厂家英文名】ABBOTT
【中文参考商品译名】
·塔卡24小时SA片剂 (1/240)毫克/片 100片/盒
·塔卡24小时SA片剂 (4/240)毫克/片 100片/盒
·塔卡24小时SA片剂 (2/240)毫克/片 100片/盒
·塔卡24小时SA片剂 (2/180)毫克/片 100片/盒
Tarka
Generic Name: trandolapril and verapamil (tran DOL a pril and ver AP a mil)
Brand Names: Tarka
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What is Tarka (trandolapril and verapamil)?
Trandolapril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme.
Verapamil is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels.
The combination of trandolapril and verapamil is used to treat high blood pressure (hypertension).
Trandolapril and verapamil may also be used for other purposes not listed in this medication guide.
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What is the most important information I should know about Tarka (trandolapril and verapamil)?
Do not use trandolapril and verapamil if you are pregnant. It could harm the unborn baby. Stop using this medication and tell your doctor right away if you become pregnant. Do not use salt substitutes or potassium supplements while taking trandolapril and verapamil, unless your doctor has told you to.
Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. This can lead to very low blood pressure, electrolyte disorders, or kidney failure while you are taking trandolapril and verapamil. Drink plenty of water each day while you are taking this medication.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
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What should I discuss with my healthcare provider before taking Tarka (trandolapril and verapamil)?
You should not use this medication if you are allergic to trandolapril (Mavik) or verapamil (Calan, Covera, Isoptin, Verelan), or if you have:
certain heart conditions, especially "sick sinus syndrome" or "AV block" (unless you have a pacemaker);
a heart rhythm disorder;
low blood pressure; or
if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), or ramipril (Altace).
If you have any of these other conditions, you may need a trandolapril and verapamil dose adjustment or special tests:
kidney disease (or if you are on dialysis);
liver disease;
congestive heart failure;
diabetes; or
a nerve-muscle disease such as muscular dystrophy.
FDA pregnancy category D. Do not use trandolapril and verapamil if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. Stop using this medication and tell your doctor right away if you become pregnant. Trandolapril and verapamil can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Trandolapril and verapamil can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
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How should I take Tarka (trandolapril and verapamil)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results.
Trandolapril and verapamil works best if you take it with food.
Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. This can lead to very low blood pressure, electrolyte disorders, or kidney failure while you are taking trandolapril and verapamil. Drink plenty of water each day while you are taking this medication.
Your blood pressure will need to be checked often. Visit your doctor regularly.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking trandolapril and verapamil. You may need to stop using the medicine for a short time.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture and heat.
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What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
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What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include slow heart rate, weak pulse, muscle weakness, tingly feeling, seizure (convulsions), feeling light-headed, or fainting.
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What should I avoid while taking Tarka (trandolapril and verapamil)?
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Do not use salt substitutes or potassium supplements while taking trandolapril and verapamil, unless your doctor has told you to.
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Tarka (trandolapril and verapamil) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
urinating less than usual or not at all;
swelling, weight gain, feeling short of breath;
feeling like you might pass out;
chest pain, slow heart rate; or
jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
cough;
headache;
runny or stuffy nose, sore throat;
constipation, diarrhea;
dizziness;
back pain;
joint pain; or
nausea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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What other drugs will affect Tarka (trandolapril and verapamil)?
Tell your doctor about all other medications you use, especially:
a diuretic (water pill);
cyclosporine (Neoral, Sandimmune, Gengraf);
digoxin (digitalis, Lanoxin);
gold injections (to treat arthritis);
lithium (Lithobid, Eskalith);
phenytoin (Dilantin) or carbamazepine (Carbatrol, Tegretol);
rifampin (Rifadin, Rifamate, Rimactane);
theophylline (Elixophyllin, Respbid, Theo-Dur, and others);
an antibiotic such as clarithromycin (Biaxin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);
heart rhythm medicine such as disopyramide (Norpace), flecainide (Tambocor), or quinidine (Quinaglute, Quinidex, Quin-Release); or
a beta-blocker such as atenolol (Tenormin), bisoprolol (Zebeta, Ziac), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Blocadren), and others.
This list is not complete and other drugs may interact with trandolapril and verapamil. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
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Where can I get more information?
Your pharmacist can provide more information about trandolapril and verapamil.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.