| 导升明 Doxium
剂型/成分/包装
胶囊羟苯磺酸钙；calcium dobesilate
500mg/胶囊；
药理作用
导升明作为血管保护剂主要作用于以下三方面：微血管壁--增加抵抗力，减低其通透性； 淋巴循环--活化作用； 血流方面--降低血液及血浆粘稠度，纠正白蛋白/球蛋白比值，降低血小板的高聚集性，从而防止血栓形成，并提高红细胞柔韧性。 导升明还可抑制血管活性物质（组织胺、5-羟色胺、缓激肽，透明质酸酶，前列腺素）对微血管引起的高通透作用，减小内皮血症，改善基底膜胶原的生物合成。
适应证
1.微血管病的治疗：糖尿性微血管病变--视网膜病及肾小球硬化症（基-威二氏综合症） 非糖尿性微血管病变--突发性或长期使用香豆素衍生物细胞抑制剂、口服避孕药或其它药物促发的微血管病变； 与慢性器质性疾病（诸如高血压、动脉硬化和肝硬变）相关的微关循环障碍。
2.静脉曲张综合症的治疗：原发性静脉曲张--疼痛、腿痛、肌肉痛性痉挛、感觉异常，手足发绀，紫癜性皮炎。 静脉曲张状态--慢性静脉功能不全(CVI)，静脉炎及表浅性血栓性静脉炎，血栓后综合征，静脉曲张性溃疡，妊娠性静脉曲张。
3.与微循环障碍伴发静脉功能不全的治疗：--痔疮综合征 --静脉曲张性静脉。
4.静脉剥离和静脉硬化法的辅助治疗。
5. 术后综合症，水肿及组织浸润的治疗。
用法和用量
胶囊（进餐时吞服，勿嚼）
静脉曲张综合症及静脉功能不全 2胶囊/日 1-3周/疗程 治疗5-6天后可见疗效,后服1-2胶囊/日以巩固疗效
糖尿病性视网膜病变 2-3胶囊/日 4-6个月/疗程 进一步治疗:每日2胶囊以维持疗效
各种微血管病 2-3胶囊/日 1-2个月/疗程 进一步治疗:每日2胶囊直至症状消失
不良反应
导升明即使长期服用也耐受良好，变态反应不能除外。 极少病例，尤在大剂量时可有胃部不适、恶心、胃灼热及厌食。 这些病例应减量或必要时中止给药。
禁忌证
对制剂的任何成份过敏； 苯磺酸钙在实验研究中并无致畸作用，也不能通过胎盘。为谨慎起见，不要使用于妊娠头三个月及哺乳期。
【原产地英文商品名】DOXIUM 500mg/cap 30caps/box
【原产地英文药品名】CALCIUM DOBESILATE
【中文参考商品译名】导升明 500毫克/胶囊 30胶囊/盒
【中文参考药品译名】羟苯磺酸钙
【生产厂家中文参考译名】奥地利依比威药品有限公司
【生产厂家英文名】Ebewe pharma Ges.m.b.H.Nfg.KG
DOXIUM® tablets
COMPOSITION:
One tablet contains 250 mg of the active substance calcium dobesilate.
PHARMACOLOGICAL CLASSIFICATION:
A. 8.1 Coagulants, haemostatics.
PHARMACOLOGICAL ACTION:
DOXIUM tablets act selectively on the capillary walls regulating their physiological functions of resistance and permeability. This action is beneficial in all cases of capillary fragility due to metabolic disturbances (constitutional or acquired), to surgical stress or induced by certain medicines.
INDICATIONS:
DOXIUM tablets are recommended as the vascular treatment of choice indiabetic retinopathy.
It has been used with good effect as a haemostatic during surgical procedures in otorhinolaryngology, ophthalmology and dentistry.
CONTRA-INDICATIONS:
There are no known contra-indications but on general principles DOXIUM tablets should not be administered during the first trimester of pregnancy.
DOSAGE AND DIRECTIONS FOR USE:
The usual daily dose is 2 to 3 tablets of 250 mg swallowed whole at meals. Duration of treatment may be from one week to several months or longer depending upon the disease condition. Half the above dose is recommended for infants.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Rarely in sensitive persons some nausea or gastric discomfort may occur but this rapidly disappears if the dose is decreased.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
This has not been encountered. In view of the extremely low toxicity of the medicines no symptoms can be predicted but if poisoning or overdosage is suspected it is recommended on general principles that vomiting be induced or gastric lavage be performed, and such symptomatic supportive therapy be administered as appears indicated.
CONDITIONS OF REGISTRATION:
None.
IDENTIFICATION:
A white, smooth biconvex tablet of 11,0 mm diameter with the mark "d." engraved on one side.
PRESENTATION:
DOXIUM tablets are supplied in bottles of 100 tablets. Each tablet contains 250 mg calcium dobesilate.
STORAGE INSTRUCTIONS:
Keep out of reach of children.
Store below 30°C. | 
