奥硝唑(ornidazole,ONZ)是第三代硝基咪唑类抗生素，该类抗生素只针对厌氧菌感染，以及原虫、滴虫感染等。其作用机制是，使通过分子的硝基在无氧环境中还原成氨基，或通过自由基的形成，使受体螺旋组织结构断裂，阻断其转录复制而衰亡。过去这类感染一直使用甲硝唑、替硝唑防治。奥硝唑引入临床后，研究人员发现，与替硝唑、甲硝唑等硝基咪唑类药物相比，该品抗感染优势更为明显。这是因为，奥硝唑药效持续时间长，其血浆消除半衰期为14.4小时，高于甲硝唑的8.4小时和替硝唑的12.7小时，可减少患者服药次数，方便使用；致突变和致畸作用低于甲硝唑与替硝唑；在抗厌氧菌感染方面，奥硝唑的最低抑菌浓度和最低杀菌浓度均小于甲硝唑和替硝唑，疗效优于甲硝唑和替硝唑；局部用药疗效好于甲硝唑和替硝唑。
奥硝唑最早由美国Hoffer.M等研制成功,于1969年5月25日获美国专利。随后Hoffer.M等将其转让给Hoffmann-LaRocheandCo(瑞士)公司，Roche公司于1977年~1983年先后在德国、法国、意大利、瑞士、澳大利亚、瑞典等国以商品名“Tiberal”上市，剂型有片剂、胶囊剂和注射液。奥硝唑在细菌性阴道病治疗中作用明显，是治疗细菌性阴道病最有效的药物。此外，该品还可治疗子宫内膜炎、子宫肌炎、输卵管或卵巢脓肿、盆腔软组织感染等。

【产地英文商品名】BITERAL VAGINAL OVULE 500mg/ovule 9ovules/box
【原产地英文药品名】ORNIDAZOLE
【中文参考商品译名】
注：以下产品不同规格和不同价格，购买时请以电话咨询为准！
·BITERAL阴道用胚珠 500毫克/胚珠 3胚珠/盒
·BITERAL阴道用胚珠 500毫克/胚珠 6胚珠/盒
·BITERAL阴道用胚珠 500毫克/胚珠 9胚珠/盒
·BITERAL 250毫克/片 20片/盒
【中文参考药品译名】奥硝唑
【生产厂家中文参考译名】DEVA
【生产厂家英文名】DEVA

TIBERAL
Tiberal Information
Tiberal is a drug from the antiprotozoals category of medications, containing the active ingredient Ornidazole. This drug acts by killing the invasive bacteria or amoeba causing an infection in the patient’s body. The following guide is for informational purpose only. For specific information regarding this medicine, as well as for specific information regarding your case, you should consult your personal health care professional.

Tiberal Indications
Tiberal is commonly prescribed for the treatment of certain types of intestinal, vaginal or urinary tract infections, as well as other infections caused by bacterial agents or by amoeba. This drug may also be prescribed as a prophylactic agent in order to prevent such infections, especially as part of surgical prophylaxis. In some cases, the examining health care professional may decide to prescribe Tiberal for the prevention or treatment of other medical conditions as well. If you would like to obtain more information on why you have been prescribed a treatment with this medicine, you are advised to consult the prescribing health care professional.

Tiberal Warnings
You should not be prescribed a treatment with Tiberal if you suffer from an allergy to this drug or to any of its ingredients. As such, you are strongly advised to inform the prescribing health care professional of any substances you are allergic to: drugs, foods, preservatives or dyes. Patients suffering from certain medical conditions such as epilepsy, liver disease or multiple sclerosis might not be able to start a treatment with Tiberal. It is recommended to make sure that the prescribing doctor is familiar with your general health condition as well as your medical history before starting a treatment with this medicine.

Tiberal may not be safe for use during pregnancy or breast feeding. Patients found in any of these situations should discuss the benefits and the risks of the treatment with their personal health care professional before they start taking this medicine.

Tiberal Intake Guidelines
It is strongly recommended that you closely follow the Tiberal intake guidelines that were given to you by the prescribing health care specialist. The intake schedule may vary from one case to another, depending on the infection that is being treated as well as on several other factors. You should set up a strict medication schedule in order to avoid missing any Tiberal doses and you should make sure that you do not exceed the recommended dosage.

Tiberal Dosage
The prescribing health care specialist will inform you regarding the Tiberal dosage most appropriate to your case. On average, the adult dosage is of three tablets (500 mg each) per day, taken in the evening for up to three days – the duration of the treatment course as well as the exact dosage may vary depending on a number of factors particular to your case. Patients that are undergoing haemodialysis are generally prescribed larger doses of this medication. Children undergoing a treatment with Tiberal will have the dosage determined by the prescribing health care professional depending on their body weight (on average 25 to 40 mg per kg) and will take the medication for up to ten days, depending on the infection being treated.

As a prophylactic agent during surgery, the average dose is of three tablets (500 mg each) taken 12 hours before the operation. After the operation you may need to take one Tiberal tablet at 12 hour intervals for an additional three to five days.

Tiberal Overdose
It is strongly advised that you do not exceed the prescribed Tiberal dosage, as this may result in severe complications. You should avoid taking larger doses of medication or taking the drug more frequently than prescribed. If you accidentally take a larger dose or if you have other reasons to believe that you may be suffering from an overdose with this drug you should immediately contact your personal physician or call the local poisons center. In severe cases, you may need to go to the nearest medical facility in order to seek emergency medical attention.

Tiberal Missed Dose
In case you miss a dose of Tiberal, you are advised to take it as soon as you remember, unless it is almost time for the next scheduled intake. In such situations it is best to skip the missed dose and continue with your normal intake schedule. You may want to consult your personal physician in order to see if any special actions need to be taken. In order to minimize the chances of missing any Tiberal doses, it is best to set up a strict intake schedule. Your personal physician may help you with advice on setting up a proper medication schedule.

Tiberal Side Effects
Some patients may experience some side effects while following a treatment with Tiberal. Among the most severe are allergic reactions; you should immediately stop taking this drug and contact your personal physician if you experience any signs or symptoms indicating an allergy (such as rashes, hives, breathing difficulties or swollen face, tongue or lips). Apart from allergies, other severe side effects that may occur are seizures, loss of consciousness, poor coordination or rigidity. More frequently, less severe side effects occur – such as nausea and vomiting, headaches, sleepiness, dizziness, skin reactions or tremors. This is not a complete list of all the possible side effects associated with Tiberal. If you experience any unexpected effects you should contact your personal health care provider in order to further investigate the situation and decide upon the course of action to follow.

Tiberal Drug Reactions
Interactions between Tiberal and other drugs are possible. Blood thinning medication such as Warfarin or muscle relaxants – for example Vecuronium Bromide – may interact with Tiberal, causing unwanted reactions. As such it is best to inform the prescribing health care professional of any drugs you are currently taking before starting a treatment with this medicine.