分类名称
一级分类：皮肤科用药 二级分类：抗炎症介质类药物 三级分类：H1受体阻断剂
药品英文名
Triprolidine
药品别名
克敏、吡咯吡胺、苯丙烯啶、曲普利定、曲普立啶、吡啶吡胺、吡咯烷甲苯丙烯、Actidil、Actidilon
药物剂型
1.胶囊：2.5mg；2.缓释片剂：10mg。
药理作用
本品为哌啶类抗组胺药，在体内与组胺竞争效应细胞上的H1受体，使组胺类物质完全丧失同H1受体结合的机会，从而抑制过敏反应的发生。因而本品对于阻断H1受体具有较高的选择性，尚未发现本品有其他药理作用。本品具有强效、长效、低毒和无中枢抑制不良反应等特点。
药动学
本品口服吸收迅速完全，给药后30min左右起效，tmax为1～3h，半衰期为14±2h，作用持续时间为8～12h。体内分布广泛，局部浓度以肺、脾、肾较高。主要经肝脏代谢，裂解成以甲苯甲基化合物为主的降解物经尿液排出，本品较少透过血-脑脊液屏障。
适应证
可用于各种过敏症，如过敏性鼻炎、荨麻疹，皮肤瘙痒症、支气管哮喘、花粉症、过敏性结膜炎等。
禁忌证
1.对本品过敏者。2.闭角型青光眼禁用。
注意事项
1.前列腺增生、幽门梗阻、膀胱颈梗阻、哮喘。2.慢性阻塞性肺病、眼压升高、甲状腺功能亢进、心脏病、高血压、老年患者慎用。
不良反应
除个别对药物有特异反应外，本品毒性及不良反应极小，偶有恶心不适等，减量或停药后症状可自制消失。
用法用量
口服：1.每次2.5～5mg，每天3次；6～12岁儿童每次3mg，每天3次；1～6岁儿童每次2mg，每天2次；1岁以下儿童1mg，每天3次或遵医嘱。2.缓释片：成人每天1次，每次1片(10mg)。
药物相应作用
乙醇可加强曲普利啶的镇静作用。
专家点评
本品有强效、长效、低毒和无中枢抑制不良反应等特点，可用于各种过敏性皮肤病，如过敏性鼻炎、荨麻疹、皮肤瘙痒、支气管哮喘、花粉症、过敏性结膜炎等。
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原产地英文商品名:
VENEN SYRUP 0.033％(ベネンシロップ0.033％) 500mls/bottle
原产地英文药品名:
TRIPROLIDINE HYDROCHLORIDE HYDRATE
原产地英文化合物名称:
trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene hydrochloride monohydrate
中文参考商品译名:
VENEN0.033％糖浆(ベネンシロップ0.033％) 500毫升/瓶
中文参考药品译名:
盐酸曲普利啶水合物
生产厂家中文参考译名:
佐藤製薬
生产厂家英文名:
Sato Pharm
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Venen (TN) for patients
Stop taking triprolidine 4 days before you have an allergy skin test. Drink water frequently or use ice chips, sugarless candy, or sugarless gum if dry mouth occurs. Coffee or tea may reduce the common side effect of drowsiness.
Venen (TN) Interactions
Triprolidine may enhance the sedative effects of central nervous system depressants including alcohol, barbiturates, hypnotics, narcotic analgesics, sedatives, and tranquillisers. The effects of anticholinergic drugs, such as atropine and tricyclic antidepressants may be enhanced by the concomitant administration of triprolidine. Triprolidine may effect the metabolism of drugs in the liver.
Venen (TN) Contraindications
Should not be administered to patients suffering from cardiovascular disease (especially coronary insufficiency), hypertension, prostatism, thyrotoxicosis, bladder dysfunction, narrow angle glaucoma, phaeochromocytoma and during an attack of asthma in asthmatic patients.
Additional information about Venen (TN)
Venen (TN) Indication: For the treatment of hay fever, urticaria (hives), and other allergic systems.
Mechanism Of Action: Venen (TN) binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Triprolidine
Synonyms: Not Available
Drug Category: Anti-Allergic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Triprolidine: Actidil; Myidyl; Triprolidine HCL; Triprolidine Hydrochloride; Venen (TN);
Absorption: Rapidly absorbed in the intestinal tract.
Toxicity (Overdose): Symptoms of overdose include drowsiness, weakness, inco-ordination, difficulty with micturition, respiratory depression, hypotension, agitation, irritability, convulsions, hypertension, palpitation and tachycardia.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 4 to 6 hours.
Dosage Forms of Venen (TN): Not Available
Chemical IUPAC Name: 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
Chemical Formula: C19H22N2
Organisms Affected: Humans and other mammals
ベネンシロップ0.033％
佐藤製薬株式会社
主成分 トリプロリジン塩酸塩水和物
剤形 無色澄明のシロップ剤