英文药名: Vastarel MR(Trimetazidine Hcl Extended Release Tablets)

中文药名: 盐酸曲美他嗪缓释片

生产厂家: Servier

盐酸曲美他嗪缓释片药品简介

【通 用 名】 盐酸曲美他嗪片
 
【别 名】 三甲氧苄嗪，心康宁，冠脉舒，VASTAREL，IDAPTAN，VASTAZIN
【外 文 名】Trimetazidine, Vastarel, Vasorel

【适 应 症】 临床适用于冠脉功能不全，心绞痛，血流动力学药物单独治疗无效的心绞痛，糖尿病冠心病，陈旧性心肌梗塞等。针剂可用于严重的心肌缺血状况如：左心室功能不全，CABG手术，PTCA手术，严重的缺血性心肌病。对伴有严重心功能不全者可与洋地黄并用。

为作用较强的抗心绞痛药，其起效较硝酸甘油慢，但作用持续时间较长。具有对抗肾上腺素、去甲肾上腺素及加压素的作用，能降低血管阻力，增加冠脉血流量及周围循环血流量，促进心肌代谢及心肌能量的产生。同时能减低心脏工作负荷。降低心肌耗氧量及心肌能量的消耗，从而改善心肌氧的供需平衡。尚能增加对强心甙的耐受性。

【注意事项】
1.个别可有头晕、食欲不振、皮疹等。
2.新近心肌梗塞病人忌用。
【规格】
35mg*180 缓释片
35mg*30 缓释片

Vastarel MR , Flavedon Preductal , Trizedon ( Trimetazidine ) Trimetazidine is a drug for angina pectoris sometimes referred to by the brand name Vastarel MR.
Each tablet contains 35 mg of trimetazidine. Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, that improves myocardial glucose utilization through inhibition of Fatty acid metabolism.
By preserving the energy metabolism in cells exposed to hypoxia or ischemia, trimetazidine prevents a decrease in intracellular adenosine triphosphate levels, thereby ensuring the proper functioning of ionic pumps and transmembranous sodium-potassium flow whilst maintaining cellular homeostasis.
The drug also inhibit b oxidation of fatty acid in blood vessles
Controlled studies in angina patients have shown that trimetazidine increases coronary flow reserve, thereby delaying the onset of ischemia associated with exercise, limits rapid swings in blood pressure without any significant variations in heart rate, significantly decreases the frequency of angina attacks, and leads to a significant decrease in the use of nitrates.
It improves left ventricular function in diabetic patients with coronary artery disease. Recently, it has been shown to be effective in patients with heart failure of different etiologies.
It is described as the first cytoprotective anti-ischemic agent, acts by directly counteracting all the major metabolic disorders occurring within the ischemic cell. The actions of trimetazidine include limitation of intracellular acidosis, correction of disturbances of transmembrane ion exchanges, and prevention of excessive production of free radicals.
It is usually prescribed as a long-term treatment of angina pectoris, and in some countries (including France) for tinnitus and dizziness.
Vastarel MR is also distributed as: Vastarel 35 mg, Vastarel LM, Vastarel LP, Preductal MR, Flavedon MR and Trizedon MR.