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英文药名：Avonex(interferon beta-1a im injection)
中文药名：干扰素β-1a IM注射冻干粉末/溶解液
生产厂家：Biogen Idec MA公司
药品介绍
Avonex(interferon beta-1a im injection)获美国被批准适用于MS复发患者，可减缓身体残疾并降低临床恶化的几率。其疗效已在MS患者中得到证实，包括首次临床发作的患者，以及MRI特征与MS一致的患者。
AVONEX（干扰素β-1a[interferon beta-1a]）注射，用于肌内注射
初始美国批准：1996
近期主要变化
警告和注意事项，血栓性微血管病：10/2015
作用机制
AVONEX在多发性硬化患者中起作用的作用机制。
适应症和用法
AVONEX是一种干扰素β，用于治疗复发型多发性硬化患者，以减缓身体残疾的积累，并减少临床恶化的频率。已经证明其功效的多发性硬化患者包括经历了第一次临床发作并具有与多发性硬化相一致的MRI特征的患者。
剂量和给药
仅供肌内使用
推荐剂量：30微克，每周一次
可以滴定AVONEX，以第一周的7.5微克开始，以减少流感样症状
在接下来的3周每周增加剂量7.5微克，直到推荐剂量为30微克
有关完整的管理说明，请参阅患者说明
在合格的医疗保健专业人员的监督下进行首次注射
治疗日的镇痛药和/或解热药可以帮助改善流感样症状
剂量形式和强度
用于注射：在一次性使用的小瓶中的30微克冻干粉末
注射：一次性预装注射器中每0.5mL溶液30微克
注射：一次性预装自动注射器，包含0.5mL溶液，30mcg
禁忌症
对天然或重组干扰素β，白蛋白或制剂的任何其它组分的超敏反应的历史
警告和注意事项
抑郁，自杀和精神障碍：建议患者立即报告抑郁症，自杀意念和/或精神病的任何症状;如果抑郁发生，考虑停止AVONEX
肝损伤：监测肝功能测试;监测患者肝损伤的体征和症状;考虑停止AVONEX如果肝损伤发生
过敏反应和其他过敏反应：如果发生停止
充血性心力衰竭：监测先前存在的显着心脏病患者的心脏症状恶化
减少外周血计数：监测全血细胞计数
血栓性微血管病：已报道血栓性微血管病的病例。如果出现与TMA一致的临床症状和实验室检查结果，则停止AVONEX
自身免疫性疾病：如果发生新的自身免疫性疾病，考虑停止AVONEX
不良反应
最常见的不良反应（AVONEX至少5％比安慰剂更频繁）是流感样症状，包括发冷，发热，肌痛和乏力。
在特定人群中使用
怀孕：根据动物数据，可能导致胎儿伤害
完整资料附件：https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d70a39cc-de15-4c12-a1ec-8063b69ea0e1
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注：以下产品不同规格和不同价格，采购以咨询为准！
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AVONEX -interferon beta-1a injection, powder, lyophilized, for solution
Biogen Idec MA Inc.
AVONEX(Interferon beta-1a)IM Injection
AvoneA
Previous Send Inquiry Product Code : av
Brand Name : Avonex Product Description
The recommended dosage of AVONEX (Interferon beta-1a) is 30 mcg injected intramuscularly once a week.
AVONEX is intended for use under the guidance and supervision of a physician. Patients may self-inject only if their physician determines that it is appropriate and with medical follow-up, as necessary, after proper training in intramuscular injection technique. Sites for injection include the thigh or upper arm (see Medication Guide).
A 25 gauge, 1 needle for intramuscular injection may be substituted for the 23 gauge, 1 needle by the prescribing physician, if deemed appropriate.
Reconstitution of AVONEX Vials
Use appropriate aseptic technique during the preparation of AVONEX. To reconstitute lyophilized AVONEX, use a sterile syringe and MICRO PIN to inject 1.1 mL of the supplied diluent, Sterile Water for Injection, USP, into the AVONEX vial. Gently swirl the vial of AVONEX to dissolve the drug completely. DO NOT SHAKE. The reconstituted solution should be clear to slightly yellow without particles. Inspect the reconstituted product visually prior to use. Discard the product if it contains particulate matter or is discolored. Each vial of reconstituted solution contains 30 mcg/1.0 mL Interferon beta-1a.
Withdraw 1.0 mL of reconstituted solution from the vial into a sterile syringe. Replace the cover on the MICRO PIN, attach the sterile needle and inject the solution intramuscularly. The AVONEX and diluent vials are for single-use only; unused portions should be discarded.
Using Avonex Prefilled Syringes
The AVONEX prefilled syringe should be held upright (cap faces up). Remove the cap by bending it at a 90angle until it snaps free. Attach the needle and inject the solution intramuscularly. The AVONEX prefilled syringe is for single-use only.
https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=12470
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