英文药名：Imunomax-γ（Interferon Gamma-1a[Genetical Recombination]） 中文药名：重组干扰素γ-1A注射剂 生产厂家：盐野义制药 イムノマックス-γ注50／イムノマックス-γ注100 治疗类别名称 重组干扰素-γ配方 欧文商標名 Imunomax-γ 一般的名称：インターフェロン　ガンマ-1a（遺伝子組換え）（JAN） Interferon Gamma-1a（Genetical Recombination） 略号： IFN-γ-1a 分子式： C761H1206N214O225S6 分子量： 17145.41 化学構造式：它是由146个氨基酸的多肽。 性状：原液是一种无色液体，承认透明或稍微浑浊。 药效药理 药理作用 1. 抗肿瘤作用（体外） 抗人肾癌来源的细胞（株Caki-1，A-498），表明干扰素α，比Beta一个强的细胞增殖抑制效果。 2.抗肿瘤作用（体内） 抗人肾癌来源的细胞移植到裸鼠（A-498），它表现出显著抑制细胞活性。 3. BRM作用 通过用直接在肿瘤细胞的人外周血淋巴细胞抑制细胞增殖，增强抗体依赖性细胞的细胞毒性作用的作用和效果一起作用NK细胞活性的增强作用，免疫介导的反应，如巨噬细胞的活化已经报道了间接肿瘤细胞毒性作用。 4.活性氧产生能力 观察到的人巨噬细胞的活性氧产生能力提高。 适应病症 1.肾癌 2.次数减少慢性肉芽肿疾病相关的严重感染的严重程度 3.蕈样肉芽肿，塞扎里综合征 用法用量 1.肾癌 生理盐水溶液或5％葡萄糖注射或类似物，和静脉滴注溶解。 方法1：日常管理 成人每天一次200万～300国内标准单位/米2（体表面积）的每一天。 方法2：间歇给药 成人每天一次100万标准单位/平方米（体表面积）的给药，连续5天，然后停药9天。这被重复两次。 然后，每天一次千万国内标准单位/平方米（体表面积）的三次给药每隔一天，随后停药9天。这被重复两次或更多次。 应当指出的是，增加或减少取决于患者的年龄和症状。 2.次数减少慢性肉芽肿疾病相关的严重感染的严重程度 一周1〜3次皮下注射，每天一次250000国内标准单位/米2（体表面积）。 此外，适当的体重减轻或当确定该困难是鉴于安全的剂量的继续停止。 超过一次250000国内标准单位/米2（体表面积）的高剂量施用。 安全性和有效性，当用剂量的上述尚未确立的剂量以上给药 3.蕈样肉芽肿，塞扎里综合征 一般，以溶解一周一次2000000国内标准单元1天生理盐水或5％葡萄糖注射液等为成人，静脉滴注的5倍。 如果效果是不够的，它可以被一次每天400国内标准单元作为上限增加。 应当指出的是，根据该状态的患者减肥。 注：对于注射剂的制备 每瓶，所附天站注射用水（免疫印迹最大-γ注50：0.5毫升，免疫最大值-γ注100：1毫升）缓慢加入并溶解，以避免剧烈的摇晃。 包装规格 Imunomax-γ注：50：1瓶 Imunomax-γ注：100：1瓶 Imunomax-γ注：300：1瓶 解决方案，日本药典注射用水（免疫印迹最大-γ注50：0.5毫升，免疫最大值-γ注100：1毫升）附。 制造厂商 盐野义制药有限公司 IMUNOMAX-gamma for Injection（Interferon Gamma-1a（Genetical Recombination）） IMUNOMAX-gamma for Injection 50（イムノマックス‐γ注50） Brand name : IMUNOMAX-gamma for Injection 50 　Active ingredient: Interferon gamma-1a (Genetical recombination) 　Dosage form: injection 　Print on wrapping: IMUNOMAX-gamma for Injection 100（イムノマックス‐γ注100）  Brand name : IMUNOMAX-gamma for Injection 100 　Active ingredient: Interferon gamma-1a (Genetical recombination) 　Dosage form: injection 　Print on wrapping: IMUNOMAX-gamma for Injection 300（イムノマックス‐γ注300）    Brand name : IMUNOMAX-gamma for Injection 300 　Active ingredient: Interferon gamma-1a (Genetical recombination) 　Dosage form: injection 　Print on wrapping:  Effects of this medicine This medicine inhibits cancer cell growth by acting on cancer cells directly. It improves immunity by activating lymphocytes, and it also damages cancer cells via immune reactions. It is usually used for the treatment of kidney cancer. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines or vaccines. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •Kidney cancer (daily use): In general, for adults, this medicine is administered by intravenous drip infusion once a day, on consecutive days. Kidney cancer (intermittent use): In general, for adults, this medicine is administered by intravenous drip infusion once a day, for 5 days, and then it is discontinued for 9 days. After this dosing schedule is repeated 2 times, this medicine is administered by intravenous drip infusion once a day, 3 times on alternate days, and then it is discontinued for 9 days. This dosing schedule is repeated more than 2 times. •The schedule for use is determined according to your symptoms. Consult with your doctor about your concrete schedule for use. Precautions while taking this medicine •If you are breastfeeding, avoid breastfeeding while using this medicine. Possible adverse reactions to this medicine The most commonly reported adverse reactions include influenza-like symptoms (fever, chill, shiver, malaise), loss of appetite, nausea, vomiting, fever, facial hot flush, itch and hives. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •fever, dry cough, breathing difficulty  [interstitial pneumonia] •feeling depressed and unmotivated, anxiety, sleeplessness, malaise  [serious depression] •swelling, shortness of breath, cough  [heart failure] •sore throat, fever, nose and/or gum bleeding, malaise, dizziness  [leukocytopenia, thrombocytopenia, pancytopenia] •thirstiness, excessive fluid intake, increased urine output  [diabetes mellitus] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •[To family members] The patient may have serious depression. Therefore, consult with your doctor immediately if the symptoms such as sleeplessness and anxiety occur. Shionogi & Co., Ltd.Injection Published: 2/2014 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. http://www.info.pmda.go.jp/go/pack/6399408F4020_1_20/ http://yakuzaishi-next.com/medicine/items/detail/11588