英文药名：HI-Z Fine Granules 20%（Gamma Oryzanol） 中文药名：谷维素细粒20％ 生产厂家：大冢制药 ハイゼット細粒20％ 治疗类别名称 高脂血症剂 心身疾病（绝经，肠易激综合症）的治疗剂 商標名 Hi-z fine granules 20％ 一般名 ※ガンマオリザノール〔Gamma Oryzanol(JAN)〕 構造式 分子式 C40H58O4 分子量 602.9 性状 在白色至浅黄色结晶或结晶性粉末，无臭，味。丙酮，微溶于氯仿或苯，和微溶于甲醇或乙醇（95），并且几乎不溶于水。 药效药理 1. 脂类代谢 (1)血脂降低效果 高胆固醇饮食的小鼠，大鼠，它显著降低兔血清总胆固醇。的降低胆固醇的作用是基于VLDL-胆固醇和LDL-胆固醇的减少。此外，在兔子它也观察一个显著降低磷脂 (2)血清过氧化脂质降低效果 伽玛谷维素是显著的高脂血症患者的血清脂质过氧化物减少为300mg/天的管理。 (3)对肝脏脂质的影响 高胆固醇饮食大鼠，兔肝脏中的胆固醇，特别是表现出酯型胆固醇的降低作用。在大鼠的甘油三酯它也显著降低。 (4)在动脉壁的效果 显著提高中性胆固醇酯酶活性在动脉壁中的高胆固醇饮食喂养的大鼠，通过显著抑制在一个方向酰基-CoA胆固醇酰基转移酶活性，以防止在动脉壁酯化胆固醇的积累行动已建议。此外，动脉粥样硬化病变形成在高胆固醇饮食兔主动脉，它减少了由于血脂的降低。 (5)抑制血小板聚集作用 通过伽玛谷维素饮食给予高胆固醇饮食兔ADP是显著抑制血小板的最大聚集率。 (6)作用机序 血清总胆固醇降低作用的机制，是一种胃肠吸收的抑制作用是胆固醇的主要动作，也被认为是分解代谢排泄促进胆固醇合成的抑制作用和胆固醇的活性的参与。 2. 内分泌和植物神经系统 (1) 这表明发情行为在切除卵巢的小鼠 (2) 显示去甲肾上腺素的营业额在间脑大鼠的抑制倾向，表现为去甲肾上腺素含量的增加效果。 (3) 它显示了增强的胃溃疡和胃肠运动的抑制作用所致加载应激大鼠。 (4) 示出了对胃分泌造成的刺激迷走神经中的胰岛素和2脱氧葡萄糖大鼠增加的抑制作用-D- 适应病证 高脂血症 心身疾病（更年期，肠易激综合征）的身体症状，以及焦虑，紧张，抑郁症 用法用量 ·高脂血症，通常为成人每天为300mg（此药物1.5克，小袋3包装的情况下）口服给药后餐可以分成三次。 ·身体症状，以及焦虑，紧张，抑郁的心身疾病，通常成人每日10-50毫克（主剂50-250毫克）口服给药。 此外，增加或减少取决于患者的年龄和症状。 然而，在肠易激综合症中使用时，和至多1天到50毫克（这种药物的250mg） 包装规格 ※※細粒20％： [HS]0.5克×200包（包10×20） [塑料瓶]100克，500G 生产厂商 大冢制药有限公司 完整处方附件：http://www.info.pmda.go.jp/go/pack/2900002C1167_1_06/ HI-Z Fine Granules 20% （Gamma Oryzanol） Brand name : HI-Z Fine Granules 20% 　Active ingredient: Gamma oryzanol 　Dosage form: white to pale yellowish fine granules 　Print on wrapping: (Front)ハイゼット細粒20%, 100mg/包 (0.5g), Otsuka (Back) Hi-z fine granules 20％, 100mg/包 (0.5g) Effects of this medicine This medicine lowers serum cholesterol mainly by suppressing intestinal absorption of cholesterol and additionally by inhibiting cholesterol synthesis and promoting cholesterol catabolism and excretion. It also modulates endocrine and autonomic nervous systems. It is usually used to treat hyperlipidemia and to improve various symptoms associated with climacteric disturbance or irritable bowel syndrome. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have liver disorder. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •Hyperlipidemia: In general, for adults, take 0.5 g or 1 pack (100 mg of the active ingredient) at a time, three times daily after meals. •Somatic symptoms and anxiety, tension, and depression associated with psychosomatic disorder (climacteric disturbance, irritable bowel syndrome): In general, for adults, take 0.05 to a 0.25 g (10 to 50 mg of the active ingredient) per day. In any case, the dosage may be adjusted according to your disease, age or symptoms, but for irritable bowel syndrome the dosage is limited to a maximum of 0.25 g (50 mg of the active ingredient) per day. Strictly follow the instructions. •If you miss a dose, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. You should never take two doses at one time. •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Precautions while taking this medicine •Follow your doctor’s instructions. Regular blood tests may be required while taking this medicine. In that case, undergo the test on your designated date and time. Possible adverse reactions to this medicine The most commonly reported adverse reactions include sleepiness, nausea/vomiting, diarrhea, skin rash, itch, abnormal skin sensation and flushing. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. No pertinent entries. The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of reach of children. Store away from direct sunlight, heat and moisture. •Discard the remainder. Do not store them. Otsuka Pharmaceutical Co., Ltd.Internal Revised: 5/2016 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.