英文药名：Hi-z tablets（Gamma Oryzanol） 中文药名：谷维素片 生产厂家：大冢制药 ハイゼット錠25mg／ハイゼット錠50mg 治疗类别名称 高脂血症剂 心身疾病（绝经，肠易激综合症），治疗剂 商標名 Hi-z tablets 25mg Hi-z tablets 50mg 一般名 ※ガンマオリザノール〔Gamma Oryzanol(JAN)〕 構造式 分子式 C40H58O4 分子量 602.9 性状 在白色至淡黄色结晶或结晶性粉末，无臭，味。丙酮，微溶于氯仿或苯，在甲醇或乙醇（95）中微溶，并且几乎不溶于水。 临床应用 谷维素主要作用于间脑的植物神经系统与分泌中枢，从而改善和调节植物神经功能失调、内分泌平衡障碍及精神失调等症状。一般用于周期性精神病、妇女更年期综合征、月经前期紧张症、脑震荡后遗症、血管性头痛、植物神经功能失调及各种神经官能症等。 常用剂量为每次10～20毫克，每日3次口服。 研究发现谷维素对其他一些疾病也有较好的疗效。 临床应用如下： （1）治疗高脂血症：谷维素可抑制胆固醇的合成。但口服剂量要大些，每次100毫克，每日3次，服用2个月后，血清胆固醇及甘油三酯均有明显下降。 （2）治疗心绞痛：每次10～20毫克，每日3次，可明显减轻症状。 （3）谷维素还常用于更年期综合征的辅助治疗，对更年期失眠、多虑有很好的改善作用。 （4）谷维素有抗心律失常作用。它可以通过调节植物神经功能，使心肌兴奋性降低。谷维素的降脂作用也可改善心肌的血液供应，起到改善睡眠的作用。老人朋友夜间易醒，适当服谷维素效果更好。 （5）谷维素虽对失眠、神经衰弱症患者有一定的调节作用，但对于重症失眠的患者作用甚微。因此重症失眠在临床的调治中，运用中西医结合的方法，用谷维素片、维生素B1片和维生素B6片等进行综合调治，会取得快速、有效的理想疗效。在用量上，建议失眠者可以每晚睡前口服2-3片，获效后即可逐渐过渡到每晚2片的维持剂量。 包装规格： 片剂（Hi-z tablets） 25mg：[PTP]500片（10片×50）   50毫克：[PTP]500片（10片×50） 制造商 大冢制药有限公司 完整处方资料附件： 片剂：http://www.info.pmda.go.jp/go/pack/2900002F4065_1_06/ HI-Z Tablets（Gamma oryzanol） HI-Z Tablets 50mg（ハイゼット錠50mg） Brand name: HI-Z Tablets 50mg 　Active ingredient: Gamma oryzanol 　Dosage form: white tablets, diameter: 8.2 mm, thickness: 4.8 mm 　Print on wrapping: (Front)OG01, 50mg, ハイゼット錠, Otsuka, ハイゼット錠50mg　(Back)Hi-z tab 50mg, ハイゼット錠50mg Effects of this medicine This medicine lowers serum cholesterol mainly by suppressing intestinal absorption of cholesterol and additionally by inhibiting cholesterol synthesis and promoting cholesterol catabolism and excretion. It also modulates endocrine and autonomic nervous systems. It is usually used to treat hyperlipidemia and to improve various symptoms associated with climacteric disturbance or irritable bowel syndrome. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have liver disorder. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •Hyperlipidemia: In general, for adults, take 2 tablets (100 mg of the active ingredient) at a time, three times daily after meals. •Somatic symptoms and anxiety, tension, and depression associated with psychosomatic disorder (climacteric disturbance, irritable bowel syndrome): In general, for adults, take 10 to 50 mg of the active ingredient per day. This medicine contains 50 mg of the active ingredient per tablet. In any case, the dosage may be adjusted according to your disease, age or symptoms, but for irritable bowel syndrome the dosage is limited to a maximum of 1 tablet (50 mg of the active ingredient) per day. Strictly follow the instructions. •If you miss a dose, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. You should never take two doses at one time. •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Precautions while taking this medicine •Follow your doctor’s instructions. Regular blood tests may be required while taking this medicine. In that case, undergo the test on your designated date and time. Possible adverse reactions to this medicine The most commonly reported adverse reactions include sleepiness, nausea/vomiting, diarrhea, skin rash, itch, abnormal skin sensation and flushing. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. No pertinent entries. The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of reach of children. Store away from direct sunlight, heat and moisture. •Discard the remainder. Do not store them. Otsuka Pharmaceutical Co., Ltd.Internal Revised: 5/2016 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.