英文药名: Travatan(Travoprost Eye Drops)

中文药名: 速为坦（曲伏前列素滴眼液）

品牌药生产厂家: Alcon Labratories Inc.
药品名称

通用名称：曲伏前列素
商品名称：苏为坦
英文名称：Travoprost　Eye　Drops
汉语拼音：Qufu qianliesu diyanye
规 格

2.5ml:0.1mg
适应症

降低开角型青光眼或高眼压症患者升高的眼压,这些患者对使用其它降眼压药不耐受或疗效不佳（多次用药后不能达到目标IOP）。
用法用量

推荐用量每晚1次,每次1滴滴入患眼。剂量不能超过每天1次,因为频繁使用会降低药物的降眼压效应。本品的降眼压作用大约在用药2小时后开始出现,在12小时达到最大。本品可以和其它眼局部用药一起用于降眼压。同时使用不止一种眼药时,每种药物的滴用时间至少间隔5分钟。
如果您有任何疑问，请遵医嘱。
不良反应

在本品的临床对照研究中,观察到的最常见眼部不良反应是眼充血,见于35%-50%的患者。大约3%的患者因结膜充血停止用药。5-10%的眼部不良反应包括视力下降,眼部不适,异物感,疼痛,瘙痒。1-4%的眼部不良反应包括视力异常、眼睑炎、视力模糊、白内障、炎性细胞、结膜炎、干眼、眼部不适、房闪、虹膜异色、角膜炎、睑缘结痂、畏光、结膜下出血和流泪。非眼部不良反应占1~5%,包括外伤、心绞痛、焦虑、关节炎、背痛、心动过缓、气管炎、胸痛、感冒综合症、抑郁、消化不良、胃肠功能紊乱、头痛、高胆固醇血症、高血压、低血压、感染、疼痛、前列腺功能紊乱、窦炎、尿失禁和尿道感染。
禁 忌

对曲伏前列素,苯扎氯铵或药物的任何成分过敏者禁用。
注意事项

据报告多剂量包装的眼局部用药在使用过程中,可引发细菌性角膜炎。眼药瓶可能不经意的被患者污染,而多数患者常常伴发角膜疾病或角膜上皮有缺损。患者虹膜棕色素可能逐步增加,这些改变可能在几个月或几年都不被发现（警告）。在多色素虹膜患者中,眼部颜色的改变最明显,例如：棕-兰、棕-灰、棕-黄和棕-绿；然而这种改变也出现在棕色眼的患者中。根据文献报道,这种颜色的改变是由于虹膜基质色素细胞内容物增加的结果,但目前对其作用机制尚未清楚。通常棕色素从受影响眼的瞳孔周围向外周呈向心性分布,但整个虹膜或部分虹膜颜色会变深。患者应根据情况定期进行检查,直到加深逐渐明显。如果色素沉着发生应停止治疗。具有眼部感染史（虹膜炎/葡萄膜炎）患者应谨慎使用本品。急性眼部感染的患者应禁止使用本品。高列腺素F2ao类似物在治疗期间有黄斑水肿包括黄斑囊样不肿的报道。这些主要见于无晶体患者,晶体后囊膜破裂的假晶体患者或有黄斑水肿危险因素的患者。本品在这类患者中使用时需谨慎。尚未对本品治疗闭角型、炎症性或新生血管性青光眼进行评价。在佩戴接触性镜片期间应禁止使用0.004%曲伏前列素滴眼液。患者应注意含有苯扎氯铵的0.004%曲伏前列素滴眼液可能被接触性镜片吸收,因此在使用本品前应将接触性镜片摘除。在滴入本品15分钟后再重新戴入镜片。
孕妇及哺乳期妇女用药

尚未在妊娠妇女中进行充分和良好对照的研究。只有在怀孕期间证明对胎儿有益,才可使用本品。哺乳期母亲：哺乳大鼠的研究显示,放射性同位素标记的曲伏前列素和/或它的代谢产物会分泌到乳汁中。是否这种药物或它的代谢物会分泌到人类乳汁尚不清楚。因为许多药物会分泌到乳汁中,所以在哺乳期妇女中应用本品时应特别小心。
儿童用药

未对儿童应用的安全性和有效性进行研究。
老年用药

老年患者与成年患者在疗效和不良反应方面总体上无明显差别。

规格：0.004% 2.5ml 

Travatan(Travoprost Eye Drops)

Travoprost eye solution

What is travoprost eye solution?

TRAVOPROST (Travatan®) helps to reduce pressure in the eye for patients with increased pressure or open-angle glaucoma. Generic travoprost eye solution is not yet available.

What should I tell my health care provider before I take this medicine?

They need to know if you have, or have had, any of these conditions:
eye abrasion, infection, or inflammation
• wear contact lenses
• closed-angle glaucoma
• kidney disease
• liver disease
• an unusual or allergic reaction to travoprost or other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Contact lenses should be removed prior to using travoprost eye solution. Contact lenses may be reinserted 15 minutes following application of travoprost to the eye.

Travoprost eye solution is only for use in the eye. Do not take by mouth. Follow the directions on the prescription label. Wash hands before and after use. Tilt the head back slightly and pull down the lower lid with the index finger to form a pouch. Try not to touch the tip of the dropper to your eye or into the pouch. Squeeze the prescribed number of drops into the pouch and gently close the eyes for 1—2 minutes. Do not blink. Use your doses at regular intervals. Do not use you medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What drug(s) may interact with travoprost eye solution?

No interactions with other medicines have been reported.

Do not use any other eye products without telling your prescriber or health care professional. Check before stopping or starting any of your medicines or non-prescription products.

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking travoprost?

Report any serious side effects promptly. Stop using travoprost if your eyes get inflamed, painful or have a discharge and see your prescriber or health care professional as soon as you can.

This medicine may cause your eye, eyelashes, and eyelids to change color. Tell your prescriber or health care professional if this occurs. If only one eye is being treated with travoprost, a difference may develop between the treated and untreated eye in eyelash length, darkness or thickness, and/or color changes of the eyelid skin or iris. These changes may be permanent.

If you wear contact lenses, be sure to remove them before placing drops in the eye. Certain chemicals in the solution can be absorbed by contact lenses. Contact lenses may be reinserted 15 minutes following application of travoprost to the eye.

Visit your prescriber or health care professional for regular checks on your progress. Report any serious side effects promptly. Stop using travoprost if your eyes get inflamed, painful, or have a discharge, and see your prescriber or health care professional immediately.

Be careful not to touch the tip of the dispensing container onto the eye, or any other surface. Serious eye infections can result from contamination of eye solutions.

If you are using another eye preparation, there should be an interval of at least 5 minutes between use of travoprost and the other eye preparations.

Wear dark glasses if travoprost makes your eyes more sensitive to light.

What side effects may I notice from using travoprost eye solution?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• any change in your vision
• inflamed or infected eyes or eyelids

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• burning, stinging, or discomfort immediately after using the solution
• changes in eye, eyelash, or eyelid color
• dry eyes
• increased flow of tears
• sensitivity of the eyes to light

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store the bottle at room temperature at 2—25 degrees C (36—77 degrees F). Throw away any unused medicine after the expiration date.