英文药名：TAPROS ophthalmic solution 0.0015%（Tafluprost） 中文药名：他氟前列素滴眼液 0.0015% 生产厂家：参天制药 タプロス点眼液0.0015％／タプロスミニ点眼液0.0015％ 治疗类别名称 前列腺素F2α衍生物 青光眼和高眼压症的治疗剂 商標名 TAPROS ophthalmic solution 0.0015％ TAPROS Mini ophthalmic solution 0.0015％ 一般名 タフルプロスト(Tafluprost) 化学名 1-Methylethyl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-butenyl]-3,5-dihydroxycyclopentyl}-5-heptenoate 構造式 分子式 C25H34F2O5 分子量 452.53 性状 无色至浅黄色粘稠液体。 乙醇，在二乙醚或乙腈非常易溶，并且几乎不溶于水。 操作注意事项 开场后Arumipiro包装，把附加的遮光药袋，并储存在2〜8℃，在6个月内使用。当在室温下储存，以1个月内可以使用。 应当指出的是，也可以前从产物打开Arumipiro包装后使用。 （只有0.0015％Tapurosumini滴眼液） 适应病症 青光眼，高眼压症 用法用量 每天一次，每次一滴。 药效药理 1. 降眼压效果 当他氟前列素眼用溶液的0.00002〜0.005％滴入单个猴，观察到依赖浓度的眼压降低作用，相较于在0.0005％以上的浓度的碱滴眼剂组这种效果是显著。同样，当为0.001％至0.005％的他氟前列素眼用溶液被重复每日滴眼一次持续5天的猴中，所有持续眼的期间稳定降眼压下降在剂量的效应的衰减没有观察到。 2. 作用机序 数据完整普罗斯特羧酸衍生物这是一种活性代谢产物，显示出高亲和性前列腺素FP受体（文=0.40nM）。使用猴，考虑房水动力学时0.005％他氟前列素眼用溶液一次，连续3至5天重复眼药水每天氟照片术方法中，通过两级恒压灌注方法和125I-131I标记白蛋白灌注方法其中，未观察到房水生产量的变化，显著增加葡萄膜巩膜外流。 3. 针对Mechiryu作用 (1) 0.0015％Tapros滴眼液兔子一次28天重复1天滴眼，用激光散斑的方法，观察到视神经乳头组织血流量的显著增加来测定。 (2) 当Tapros眼用溶液0.0015％滴眼单个健康成人，血流速度的组织血流量的显著增加和邻近视神经乳头视网膜附近观察视神经头视网膜动脉。 包装规格 TAPROS ophthalmic滴眼液 0.0015％： 塑料吸管：2.5毫升×5管，2.5毫升×10管 TAPROS Mini滴眼液 0.0015%： 塑料吸管：0.3毫升×30管/盒 （1袋：10瓶×3袋Arumipiro） 制造厂商 参天制药有限公司 注：以上中文资料仅供参考，使用以原处方为准：http://www.info.pmda.go.jp/go/pack/1319756Q1022_1_11/ TAPROS Mini ophthalmic solution 0.0015%（Tafluprost）/TAPROS ophthalmic solution 0.0015%（Tafluprost） TAPROS Mini ophthalmic solution 0.0015%（タプロスミニ点眼液0.0015%）  Brand name: TAPROS Mini ophthalmic solution 0.0015% 　Active ingredient: Tafluprost 　Dosage form: limpid and colorless, ophthalmic solution, 0.3mL, (bottle) clear and colorless, (label) front: white, back: red 　Print on wrapping: TAPROS ophthalmic solution 0.0015%（タプロス点眼液0.0015%）  Brand name: TAPROS ophthalmic solution 0.0015% 　Active ingredient: Tafluprost 　Dosage form: limpid and colorless, ophtalmic solution, 2.5mL, (bottle) clear and colorless, (cap) bright blue green 　Print on wrapping:  Effects of this medicine This medicine lowers pressure in the eye by promoting aqueous humor outflow by stimulating prostanoid FP receptor. It is usually used to treat glaucoma or ocular hypertension. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. It you have: aphakic/pseudophakic eyes, bronchial asthma/history of bronchial asthma, or intraocular inflammation (iritis, uveitis). If you wear contact lenses. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •In general, apply 1 drop at a time, once a day. Strictly follow the instructions. •Before applying, wash your hands thoroughly with soap and running water. Pull down your lower eyelid so that the dropper tip does not touch eye or eyelashes and apply the medicine. After applying, keep your eyes closed for 1 to 5 minutes pressing the inner corner of the eye lightly. Wipe off any excess liquid with a wet gauze or tissue immediately, or wash your face with eyes closed. If you need to apply other eye drops at the same time, wait more than 5 minutes. •If you wear contact lenses, take off the lenses and then apply. Wait more than 15 minutes to wear contact lenses again. •If you miss a dose, apply 1 drop as soon as possible in case of the same day. If you notice on the next day, skip the missed dose and continue your regular dosing schedule. You should not apply twice a day or 2 drops at one time. •If you accidentally apply more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop applying this medicine unless your doctor instructs you to do so. Precautions while taking this medicine •This medicine may cause blurred vision temporarily after applying. Do not operate machinery or drive a car until these symptoms recover. Possible adverse reactions to this medicine The most commonly reported adverse reactions include bloodshot eyes, changes in eyelashes (increased length, thickness and number of lashes), itchy/stinging eyes, eyelid pigmentation (darkening around the eyes), corneal epithelial disorder (eye pain, focus disorder, foreign body sensation in eyes), and hypertrichosis of eyelid. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •changes in the color of the iris [iris pigmentation] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •The amount of contents seems to be insufficient because 2.5mL of solution is packed in a 5mL plastic bottle. •Keep out of reach of children. Store away from direct sunlight and heat. •Discard the remainder. Do not store them. Ask your pharmacy or medical institution how to discard. Santen Pharmaceutical Co.,Ltd.External Revised: 5/2015 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. 他氟前列腺素(Tafluprost)治疗青光眼和眼高压 他氟前列腺素(Tafluprost)由日本参天制药和默沙东公司联合开发，商品名“Saflutan”，于2008年首次在德国上市，用于治疗原发性开角型青光眼和高眼压。 0.005%Tafluprost作为PGFP受体激动药，降眼压机制为主要为增加葡萄膜巩膜途径房水流出从而降低眼压；部分降眼压作用可能是通过PGFP受体介导前列腺素产生，再通过PGEP3受体来增加房水流出从而降低眼压。 临床研究证实0.005%Tafluprost降低健康人眼压效果明显优于0.005%拉坦前列腺素。