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部份中文阿普唑仑处方资料（仅供参考）
【中文品名】阿普唑仑
【药效类别】催眠镇静药>苯并二氮卓类
【通用药名】ALPRAZOLAM
【别 名】安宁甲，佳乐定，甲基三唑氯安定, 三唑安定, 佳静安定，Xanax，U-31889，D- 65MT，TUS-1
【化学名称】 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
【CA登记号】[28981-97-7]
【结 构 式】
【分 子 式】C17H13ClN4
【分 子 量】308.76
【收录药典】JP14
【开发单位】Upjohn (美国)
【首次上市】1981年，美国
【性 状】白色或类白色结晶性粉未，微苦。易溶于三氯甲烷，略溶于乙醇、丙酮，几乎不溶于水和乙醚。mp229~230℃。
【用 途】苯并二氮卓类镇静催眠药。用于治疗焦虑症或焦虑症状的短期治疗。亦可用于伴有忧郁症状的焦虑症。还可用于在治疗中的开角型青光眼患者。
注：本品属管控药
生产厂家：美国辉瑞公司
Xanax (alprazolam Tablets)
Generic Name and Formulations:
Alprazolam 0.25mg, 0.5mg, 1mg, 2mg+; scored tabs (+multi-scored).
Company:
Pfizer Inc.
Select therapeutic use: Anxiety/OCD
Indications for XANAX:
Anxiety. Panic disorder.
Adult:
Adjust at intervals of at least 3–4 days. ≥18yrs: Anxiety: initially 0.25–0.5mg 3 times daily; max 4mg daily in divided doses. Elderly or debilitated: initially 0.25mg 2–3 times daily. Panic disorder: initially 0.5mg 3 times daily; usual range: 5–6mg daily in divided doses; max 10mg/day.
Children:
<18yrs: not recommended.
Contraindications:
Acute narrow-angle glaucoma. Concomitant itraconazole, ketoconazole.
Warnings/Precautions:
Not for use in untreated open-angle glaucoma. Reevaluate periodically. Change dose gradually. Withdrawal symptoms on abrupt cessation or dose reduction. Suicidal ideation. Psychosis. Mania. Renal, cardiovascular, hepatic, pulmonary dysfunction (monitor). Obesity. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended.
Interactions:
See Contraindications; other azole antifungals: not recommended. Potentiates CNS depression with alcohol, psychotropics, anticonvulsants, other CNS depressants. Potentiated by CYP3A inhibitors; reduce alprazolam dose; caution with cimetidine, nefazodone, fluvoxamine; caution with weaker CYP3A inhibitors (eg, fluoxetine, propoxyphene, oral contraceptives). Antagonized by CYP3A inducers (eg, carbamazepine). May increase levels of imipramine, desipramine.
See Also:
XANAX XR
Pharmacological Class:
Benzodiazepine.
Adverse Reactions:
CNS depression; impaired memory, coordination, or attention; dysarthria, ataxia, arthralgia, dyspnea, paradoxical excitement, increased salivation, withdrawal seizures, tremors, decreased libido, sexual dysfunction.
How Supplied:
XR—60; Tabs 0.25mg, 0.5mg, 1mg—100, 500, 1000; 2mg—100, 500 |
