部分中文富露施处方资料（仅供参考）

【成分】 n-乙酰半胱氨酸 n-acetylcysteine

【药理作用】
n-乙酰-l-半胱氨酸(nac)是本药的活性成分，它通过化学结构中的一个能与亲电子的氧化基团相互发生作用的自由巯基(亲核的-sh)使粘蛋白的双硫键(-s-s-)断裂而分解粘蛋白复合物、核酸，液化粘液分泌物，降低痰粘度。同时本药可以增加纤毛的摆动频率和粘液的周转率，使粘痰容易咳出。这些特性使得本药特别适用治疗以浓厚的粘液及脓性的粘性分泌物为特征的急性和慢性呼吸系统感染。此外，本药的分子结构使它容易透过细胞膜。在细胞内，n-乙酰-l-半胱氨酸脱去乙酰基，形成l-半胱氨酸，这是一种合成谷胱甘肽(gsh)的必需氨基酸。因此，本药具有切实的抗氧化功能。n-乙酰-l-半胱氨酸在保持适当的gsh水平方面起着重要的作用，从而有助于保护细胞不因体内gsh水平过低而导致细胞毒素损害。由于具有这种作用机理，n-乙酰-l-半胱氨酸可以作为一种特效的解毒剂用于扑热息痛中毒、环磷酰胺化疗、出血性膀胱炎。
【适应证】 以浓稠的粘液分泌物过多引起的呼吸困难、咳痰困难。
【用量和用法】
临用前，加少量水溶解(小于等于 40°c)，混匀。 成人 200 mg-400 mg/次，一日2-3次口服。儿童 100 mg/次，依照年龄一日2-4次。
【禁忌】 对本品过敏者忌用。

【注意事项】 患有严重支气管哮喘的病人，糖尿病患者慎用。

【不良反应】 偶见恶心、呕吐，罕见皮疹和支气管痉挛等过敏反应。

Fluimucil - General Information:
The N-acetyl derivative of cysteine. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates. [PubChem]

Pharmacology:
Fluimucil has been shown to reduce the extent of liver injury following acetaminophen overdose. It is most effective when given early, with benefit seen principally in patients treated within 8-10 hours of the overdose. Fluimucil likely protects the liver by maintaining or restoring the glutathione levels, or by acting as an alternate substrate for conjugation with, and thus detoxification of, the reactive metabolite.

Additional information about Fluimucil
Fluimucil Indication: Used mainly as a mucolytic and in the management of paracetamol (acetaminophen) overdose.
Mechanism Of Action: Fluimucil may protect against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione. Glutathione is required to inactivate an intermediate metabolite of acetaminophen that is thought to be hepatotoxic. In acetaminophen overdose, excessive quantities of this metabolite are formed because the primary metabolic (glucuronide and sulfate conjugation) pathways become saturated. Fluimucil may act by reducing the metabolite to the parent compound and/or by providing sulfhydryl for conjugation of the metabolite. Experimental evidence also suggests that a sulfhydryl-containing compound such as acetylcysteine may also directly inactivate the metabolite. Inhalation - Fluimucil exerts its mucolytic action through its free sulfhydryl group, which opens the disulfide bonds and lowers mucus viscosity. This action increases with increasing pH and is most significant at pH 7 to 9. The mucolytic action of acetylcysteine is not affected by the presence of DNA.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Acetylcysteine
Synonyms: N-acetylcysteine; NAC
Drug Category: Antiviral Agents; Expectorants; Free Radical Scavengers
Drug Type: Small Molecule; Approved
Other Brand Names containing Acetylcysteine: ACC; Mucomyst; Acetadote; Fluimucil; Parvolex; Lysox; Mucolysin;
Absorption: Bioavailability is 6–10% following oral administration and less than 3% following topical administration.
Toxicity (Overdose): Single intravenous doses of acetylcysteine at 1000 mg/kg in mice, 2445 mg/kg in rats, 1500 mg/kg in guinea pigs, 1200 mg/kg in rabbits and 500 mg/kg in dogs were lethal. Symptoms of acute toxicity were ataxia, hypoactivity, labored respiration, cyanosis, loss of righting reflex and convulsions.
Protein Binding: 83%
Biotransformation: Hepatic. Deacetylated by the liver to cysteine and subsequently metabolized.
Half Life: 5.6 hours (adults), 11 hours (neonates)
Dosage Forms of Fluimucil: Liquid Respiratory (inhalation)
Solution Respiratory (inhalation)
Chemical IUPAC Name: (2R)-2-acetamido-3-sulfanylpropanoic acid
Chemical Formula: C5H9NO3S
Organisms Affected: Humans and other mammals
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注：以下产品不同规格和不同价格，购买时请以电话咨询为准！
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产地国家: 欧洲共同体国家
原产地英文商品名:
FLUIMUCIL EFFERVESCENT 200MG/TAB 100TABS/BOX
原产地英文药品名:
ACETYLCYSTEINE
中文参考商品译名:
富露施泡腾片 200毫克/片 100片/盒
中文参考药品译名:
乙酰半胱氨酸
生产厂家中文参考译名:
Pierre Fabre Pharma
生产厂家英文名:
Pierre Fabre Pharma
--------------------------------------------------------------------
原产地英文商品名:
FLUIMUCIL EFFERVESCENT 200MG/TAB 50TABS/BOX
原产地英文药品名:
ACETYLCYSTEINE
中文参考商品译名:
富露施泡腾片 200毫克/片 50片/盒
中文参考药品译名:
乙酰半胱氨酸
生产厂家中文参考译名:
Pierre Fabre Pharma
生产厂家英文名:
Pierre Fabre Pharma
----------------------------------------------------------------
原产地英文商品名:
FLUIMUCIL EFFERVESCENT 200MG/TAB 20TABS/BOX
原产地英文药品名:
ACETYLCYSTEINE
中文参考商品译名:
富露施泡腾片 200毫克/片 20片/盒
中文参考药品译名:
乙酰半胱氨酸
生产厂家中文参考译名:
Pierre Fabre Pharma
生产厂家英文名:
Pierre Fabre Pharma
------------------------------------------------------------------
原产地英文商品名:
FLUIMUCIL EFFERVESCENT 600MG/TAB 10TABS/BOX
原产地英文药品名:
ACETYLCYSTEINE
中文参考商品译名:
富露施泡腾片 600毫克/片 10片/盒
中文参考药品译名:
乙酰半胱氨酸
生产厂家中文参考译名:
赞邦制药
生产厂家英文名:
Zambon
-------------------------------------------------------------------
原产地英文商品名:
FLUIMUCIL EFFERVESCENT 100MG/TAB 20TABS/BOX
原产地英文药品名:
ACETYLCYSTEINE
中文参考商品译名:
富露施泡腾片 100毫克/片 20片/盒
中文参考药品译名:
乙酰半胱氨酸
生产厂家中文参考译名:
Pierre Fabre Pharma
生产厂家英文名:
Pierre Fabre Pharma