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中文名称：丙酸氟替卡松
英文名称：Fluticasone propionate
中文别名：氟替卡松丙酸酯;(6a,11B,16a,17a)-6,9-二氟-11-羟-16-甲基-3-氧代-17-(1-氧代丙氧基)-雄甾-1,4-二烯-17-硫代羧酸 S-(氟甲基)酯;丙酸氟替卡松;6,9-二氟-11羟基甲基氧代(氧代丙氧基)雄甾,二烯硫代羧酸-S-氟甲酯;(6Α,11Β,16Α,17Α)-6,9-二氟-11-羟基-16-甲基-3-氧代17-(1-氧丙氧基)雄甾-1,4-二烯-17-硫代羧酸S-(氟甲基)酯
英文别名：AtemurMite;Cutivate;Cutivate cream;Cyclesonide;Flixonase;FlixonaseNasal Spray;Flixotide;Flixotide Disk;Flixotide Disks;Flixotide Inhaler;Flonase;Flonase Aq;Flovent;Flovent Diskus;Flunase;Fluticasone17-propionate;
CAS No.：80474-14-2
分 子 式：C25H31F3O5S
分 子 量：500.57
安全术语：S22;S24/25;
分子结构式：
通用名称
丙酸氟替卡松50mcg/inh，100mcg/inh，250mcg/inh干密码吸入，吸入装置的水泡。
公司名称：
葛兰素史克制药
适应症FLOVENT DISKUS：
维持治疗哮喘的预防性治疗。需要全身性皮质类固醇激素治疗哮喘，口服全身性类固醇，以减少需要。
成人剂量使用Flovent DISKUS：
≥11岁：以前对支气管扩张剂：最初100mcg，每日两次;最大500mcg，每日两次。以前吸入糖皮质激素：最初100-250mcg，每日两次;500mcg每日两次。以前口服皮质类固醇（戒除逐渐）：最初的5001000mcg每日两次;1000mcg每日两次。漱口后使用。
儿童的剂量为FLOVENT DISKUS：
<4yrs：不推荐使用。 4-11岁：以前支气管扩张剂单独或吸入糖皮质激素：最初50mcg，每天两次;100mcg每日两次。漱口后使用。
药理分类：
类固醇。
禁忌症：
不为急性发作的主要治疗方法。
警告/注意事项：
保持经常性的方案。感染。如果暴露于水痘或麻疹，考虑抗感染的预防性治疗。如果存在肾上腺皮质功能不全，全身性皮质类固醇治疗后，更换吸入糖皮质激素可能会加剧肾上腺皮质功能不全的症状（例如，精神不振）。监测儿童生长抑制。监测亢进和HPA轴的抑制（如果逐渐出现停止）。肝功能不全（监视器）。从传输口服皮质类固醇：见文献。怀孕（Cat.C）。哺乳期的母亲。
药物相互作用：
避免利托那韦。注意与强效的CYP3A4抑制剂（如酮康唑）。
不良反应：
局部效应（咽炎，鼻塞/放电，鼻炎，发音，鼻窦炎，口腔念珠菌病），上呼吸道感染，头痛，感冒，支气管痉挛。
如何提供：
DISKUS（60水泡）-1
Generic Name and Formulations:
Fluticasone propionate 50mcg/inh, 100mcg/inh, 250mcg/inh; dry pwd for inhalation; blisters with inhalation device.
Company:
GlaxoSmithKline Pharmaceuticals
Indications for FLOVENT DISKUS:
Maintenance treatment of asthma as prophylactic therapy. Asthma requiring systemic corticosteroid therapy, to reduce need for oral systemic corticosteroids.
Adult Dose for FLOVENT DISKUS:
≥11yrs: Previously on bronchodilators alone: initially 100mcg twice daily; max 500mcg twice daily. Previously on inhaled corticosteroids: initially 100–250mcg twice daily; max 500mcg twice daily. Previously on oral corticosteroids (wean gradually): initially 500–1000mcg twice daily; max 1000mcg twice daily. Rinse mouth after use.
Children's Dose for FLOVENT DISKUS:
<4yrs: not recommended. 4–11yrs: Previously on bronchodilators alone or on inhaled corticosteroids: initially 50mcg twice daily; max 100mcg twice daily. Rinse mouth after use.
Pharmacological Class:
Steroid.
Contraindications:
Not for primary treatment of acute attack.
Warnings/Precautions:
Maintain regular regimen. Infections. If exposed to chickenpox or measles, consider anti-infective prophylactic therapy. If adrenal insufficiency exists following systemic corticosteroid therapy, replacement with inhaled corticosteroids may exacerbate symptoms of adrenal insufficiency (eg, lassitude). Monitor for growth suppression in children. Monitor for hypercorticism and HPA axis suppression (if occur discontinue gradually). Hepatic impairment (monitor). Transferring from oral corticosteroids: see literature. Pregnancy (Cat.C). Nursing mothers.
Interactions:
Avoid ritonavir. Caution with potent CYP3A4 inhibitors (eg, ketoconazole).
Adverse Reactions:
Local effects (pharyngitis, nasal congestion/discharge, rhinitis, dysphonia, sinusitis, oral candidiasis), upper respiratory infection, headache, influenza, bronchospasm.
How Supplied:
Diskus (60 blisters)—1
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