英文药名：VEPESID Capsules（Etoposide） 中文药名：依托泊苷胶囊 生产厂家：百时美施贵宝 ベプシドカプセル50mg／ベプシドカプセル25mg 药物分类名称 抗肿瘤药 批准日期：2007年12月 欧文商標名 VEPESID Capsules 一般名 エトポシド（Etoposide） 化学名 (5R,5aR,8aR,9S)-9-{[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy}-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4'：6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one 構造式 分子式 C29H32O13 分子量 588.56 性状 依托泊苷是白色结晶或结晶性粉末。 它微溶于甲醇，几乎不溶于乙醇（99.5），非常不溶于水。 熔点 约260°C（分解） 药效药理 1. 抗肿瘤作用 确认抗小鼠能够移植的Lewis肺癌的抗肿瘤作用。 Lu-134，N231，Lu-24，Lu-61），裸鼠皮下移植人宫颈癌（HeLa S3，TCO -1）和裸鼠子宫移植人宫颈癌（HeLa S3）。 2. 作用机序 它对细胞周期的S期后期的G 2期细胞具有杀细胞作用，其作用机制不是直接作用于DNA，而是可能抑制进行DNA结构转化的酶拓扑异构酶II的活性。 此外，根据作用浓度和作用时间两者，能增强细胞杀伤作用。 适应病症 肺癌细胞癌，恶性淋巴瘤，子宫颈癌，卵巢癌等癌症化疗后恶化 用法与用量 1. 肺小细胞癌 通常每天175至200mg的成人口服连续服用5天，并且将其撤出3周。 让这是一个课程，重复给药。 剂量可以根据疾病和症状而增加或减少。 2. 恶性淋巴瘤 根据病人的情况选择方法A或方法B. 方法A 作为依托泊苷，通常每天175至200mg的成人口服连续服用5天，并且将其撤出3周。 让这是一个课程，重复给药。 剂量可以根据疾病和症状而增加或减少。 方法B 作为依托泊苷，通常每天口服50mg成人每天连续服用21天，并将药物取出1-2周。 让这是一个课程，重复给药。 剂量可以根据疾病和症状而增加或减少。 3. 子宫颈癌 通常每天口服50mg成人每天连续服用21天，并将药物取出1-2周。 让这是一个课程，重复给药。 根据疾病和症状适当减少剂量。 4. 癌症化疗后卵巢癌加剧 每天连续给予50mg/m 2的成年人口服21天，并将药物撤出1周。 让这是一个课程，重复给药。 顺便提及，根据患者的状况进行体重减轻。 包装规格 胶囊 50毫克：20粒 25毫克：40粒 制造厂商 百时美施贵宝有限公司 完整说明书附件：http://www.info.pmda.go.jp/go/pack/4240001M1075_1_07/ VePesid 50mg (Etoposide) - Generic What is Generic VePesid (Etoposide)? Generic VePesid (Etoposide) is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body.Generic VePesid (Etoposide) is used to treat cancer of the lung or testicles.Generic VePesid (Etoposide) may also be used for purposes other than those listed in this medication guide. What is the most important information I should know about Generic VePesid (Etoposide)? Do not use this medication without your doctor's consent if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. Do not break or open an Generic VePesid (Etoposide) capsule. The medicine from a broken capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If skin contact occurs, wash the area with soap and water or rinse the eyes thoroughly with plain water. If you must handle a broken capsule, ask your doctor or pharmacist how to safely dispose of the capsule. Generic VePesid (Etoposide) can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.Using Generic VePesid (Etoposide) may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk. What should I discuss with my healthcare provider before taking Generic VePesid (Etoposide)? Before using Generic VePesid (Etoposide), tell your doctor if you have:kidney disease; or a weak immune system (from disease or from taking certain medicines).If you have any of these conditions, you may not be able to use Generic VePesid (Etoposide), or you may need a dosage adjustment or special tests during treatment.FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use Generic VePesid (Etoposide) without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. It is not known whether Generic VePesid (Etoposide) passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Using Generic VePesid (Etoposide) may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk. How should I use Generic VePesid (Etoposide)? Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.Take each dose with a full glass of water. Do not break or open an Generic VePesid (Etoposide) capsule. The medicine from a broken capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If skin contact occurs, wash the area with soap and water or rinse the eyes thoroughly with plain water. If you must handle a broken capsule, ask your doctor or pharmacist how to safely dispose of the capsule. Generic VePesid (Etoposide) can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor. Store Generic VePesid (Etoposide) capsules in the refrigerator. Do not allow them to freeze. What happens if I miss a dose? Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an Generic VePesid (Etoposide) overdose may include severe nausea and vomiting, fever, chills, sore throat, flu symptoms, easy bruising, or extreme weakness. What should I avoid while using Generic VePesid (Etoposide)? Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection.Do not receive a "live" vaccine while you are being treated with Generic VePesid (Etoposide). Side effects of Generic VePesid (Etoposide) Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: fever, chills, body aches, flu symptoms;white patches or sores inside your mouth or on your lips;easy bruising or bleeding, unusual weakness;fast heart rate;severe nausea and vomiting;feeling light-headed, fainting; orlow fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).Other, less serious side effects may be more likely to occur, such as:mild nausea, vomiting, stomach pain;mild itching or skin rash; ortemporary hair loss.Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect Generic VePesid (Etoposide)? Before using Generic VePesid (Etoposide), tell your doctor if you are using cyclosporine (Neoral, Sandimmune, Gengraf).There may be other drugs that can affect Generic VePesid (Etoposide). Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.