药品介绍
【中文别名】米力农、甲氰吡酮、甲腈联吡啶酮、卡巴喹伦、米利酮
【英文别名】Corotrop、Corotrope、Milrinone Lactate、Primacor
【药品类别】强心药
【药理作用】
本品系氨利酮衍生物，具有正性肌力和扩张血管作用。主要通过抑制磷酸二酯酶同功酶 Ⅲ，使心肌内环磷酸腺苷(cAMP)含量升高、加快Ca2+内流而增强心肌收缩。其正性肌力作用较氨利酮强 10～40倍。其扩张外周血管作用也较强。其心血管效应与剂量大小有关。小剂量时主要表现为正性肌力作用，当剂量增大，逐渐达到稳定状态的最大正性肌力效应时，其扩张血管的作用也随着剂量的增加而逐渐加强。
【药动学】
口服吸收良好，给药后血浆药物峰值浓度与给药剂量有关。一般在口服后 0.5h开始生效，1～3h达峰值，持续时间为 4～6h。生物利用度为 92％，心衰患者的消除半减期为 3.3～2.7h。主要在肝脏代谢失活，80％以原形从尿中排出。
【适应症】
临床口服或静滴对慢性充血性心力衰竭均有满意疗效，其增加心脏指数优于氨吡酮，对动脉压和心率无明显影响．
主要用于治疗重度充血性心力衰竭患者，也可在常规应用洋地黄和利尿剂的基础上加用本品治疗。本品短期奏效明显，且副作用较氨利酮为小，但其远期疗效尚待进行大量的临床观察而定论。
适用于强心药、利尿药、血管扩张药治疗无效的充血性心力衰竭。
【用法用量】
米力农注射液可用适量生理盐水或葡萄糖液稀释后，先按37.5ug/kg-50ug/kg缓慢静脉注射10分钟(注射过快，可能出现室性早搏)，继续以0.37ug/kg-0.75ug/kg/min 静脉滴注，此后根据临床效应调整用量。
【贮藏】密闭保存
【不良反应】
剂量过大可有低血压(血压下降),心动过速.长期使用可增加慢性心衰患者死亡率.
较少见，可有低血压、头痛、胸痛、肌无力、失眠、震颤、血小板减少、低血钾和室性心律失常。
米力农治疗时有12％的病人出现室性心律紊乱，所以在治疗充血性心力衰竭时应密切注意这种不良反应的出现。据报道，发生的室性心律紊乱中有9％为心室异位搏动，3％为非持续性室性心律紊乱，1％的为持续性室性心律紊乱和0.2％的室性纤维颤动。其它的不良反应有室上性心律紊乱(4％)、低血压(3％)、心绞痛或胸痛(1％)和头痛(3％)、震颤和血小板减少症。
【禁忌症】
对本品过敏者及严重室性心律失常禁用。
急性心肌梗死早期患者及孕妇慎用。
对严重主动脉梗阻或肺动脉瓣病应小心使用，更不能代替这些梗阻的外科手术。
肝、肾功能损害严重者慎用。
尚无用于孕妇哺乳及儿童的经验，使用时需权衡利弊。
【药物相互作用】
本品与地高辛合用，有协同的强心作用。
呋塞米和米力农两者在溶液中混合时可产生沉淀，因此两者不能混在一起同时注射。也不可与布美他尼配伍。
与常用强心药、利尿药、血管扩张药合用，临床未见不良相互作用，与多巴胺、多巴酚丁胺合用有协同作用。

milrinoneGeneric Name: milrinone (MIL ri none)Brand names: Primacor, Primacor I.V.
What is milrinone?
Milrinone is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries.
Milrinone is used as a short-term treatment for treat life-threatening heart failure.
Milrinone may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about milrinone?
You should not receive this medication if you are allergic to milrinone, or if you have recently had a heart attack.
If possible before you receive milrinone, tell your doctor if you have a heart rhythm disorder or low levels of potassium in your blood (hypokalemia), or if you are pregnant or breast-feeding.
In an emergency situation, it may not be possible before you are treated to tell your caregivers about any health conditions you have or if you are pregnant or breast-feeding. However, make sure any doctor caring for you afterward knows that you have received this medication.
Tell your doctor about all other medications you use, especially digoxin (digitalis, Lanoxin, Lanoxicaps), or a diuretic (water pill).
While receiving milrinone, tell your caregivers at once if you have a serious side effect such as chest pain, feeling like you might pass out, wheezing or trouble breathing, confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, or muscle weakness.
What should I discuss with my healthcare provider before I receive milrinone?
You should not receive this medication if you are allergic to milrinone, or if you have recently had a heart attack. If possible before you receive milrinone, tell your doctor if you have a heart rhythm disorder or low levels of potassium in your blood (hypokalemia). FDA pregnancy category C. It is not known whether milrinone is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether milrinone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
In an emergency situation, it may not be possible before you are treated with milrinone to tell your caregivers if you are pregnant or breast-feeding. However, make sure any doctor caring for your pregnancy or your baby knows that you have received this medication.
How is milrinone given?
Milrinone is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. Milrinone is usually given around-the-clock for up to 48 hours.
Your heart rate and blood pressure will be constantly monitored while you are being treated with milrinone. Your kidney function and electrolytes may also need to be checked with blood tests.
What happens if I miss a dose?
Since milrinone is given by a healthcare professional, you are not likely to miss a dose.
What happens if I overdose?
Tell your caregivers right away if you think you have received too much of this medicine.
Overdose can cause severe dizziness or fainting.
What should I avoid after receiving milrinone?
Follow your doctor's instructions about any restrictions on food, beverages, or activity after your treatment with milrinone.
Milrinone side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have a serious side effect such as:
chest pain;
feeling like you might pass out;
bronchospasm (wheezing, chest tightness, trouble breathing); or
low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).
Less serious side effects may include:
headache;
tremors; or
easy bruising or bleeding.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Milrinone Dosing Information
Usual Adult Dose for Congestive Heart Failure:
Loading dose: 50 mcg/kg IV over 10 minutes.Maintenance infusion: 0.375-0.75 mcg/kg/min.
What other drugs will affect milrinone?
Tell your doctor about all other medications you use, especially:
digoxin (digitalis, Lanoxin, Lanoxicaps); or
diuretic (water pill).
This list is not complete and there may be other drugs that can interact with milrinone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

附件：
201042800491525.pdf
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注：以下产品不同规格和不同价格，购买时请以电话咨询为准！
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产地国家: 美国
原产地英文商品名:
MILRINONE LACTATE 1mg/ml 20ml/vial 25vials/box
原产地英文药品名:
MILRINONE LACTATE
中文参考商品译名:
乳酸米力农 1毫克/毫升 20毫升/瓶 25瓶/盒
中文参考药品译名:
乳酸米力农
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产地国家: 美国
原产地英文商品名:
MILRINONE LACTATE 1mg/ml 10ml/vial 10vials/box
原产地英文药品名:
MILRINONE LACTATE
中文参考商品译名:
乳酸米力农 1毫克/毫升 10毫升/瓶 10瓶/盒
中文参考药品译名:
乳酸米力农
---------------------------------------------------------------
产地国家: 美国
原产地英文商品名:
MILRINONE LACTATE 1mg/ml 50ml/vial
原产地英文药品名:
MILRINONE LACTATE
中文参考商品译名:
乳酸米力农 1毫克/毫升 50毫升/瓶
中文参考药品译名:
乳酸米力农