Esomeprazole Magnesium Hydrate）(JAN)
化学名：Bis{5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1H-benzimidazol-1-yl}monomagnesium trihydrate
構造式：
分子式：C34H36N6O6S2Mg・3H2O
分子量：767.17
融点　：約170℃ 
适应症
胃食管反流性疾病（GERD)
-糜烂性反流性食管炎的治疗
-已经治愈的食管炎患者防止复发的长期维持治疗
-胃食管反流性疾病（GERD)的症状控制
与适当的抗菌疗法联合用药根除幽门螺旋杆菌
-愈合与幽门螺旋杆菌感染相关的十二指肠溃疡
-防止与幽门螺旋杆菌相关的消化性溃疡复发
Generic Name for NEXIUM
Esomeprazole (as magnesium trihydrate) 20mg, 40mg; caps containing e-c delayed-release pellets.
Legal Classification:
Rx
Pharmacological Class for NEXIUM
Proton pump inhibitor.
Manufacturer of NEXIUM
AstraZeneca Pharmaceuticals
      
Indications for NEXIUM
Triple therapy (w. amoxicillin + clarithromycin) for H. pylori eradication in duodenal ulcer disease. Short-term treatment and maintenance of healing of erosive esophagitis (EE), symptomatic GERD. To reduce risk of NSAID-associated gastric ulcer. Long-term treatment of pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome).
      
Adult dose for NEXIUM
Take 1 hour before food. Caps: swallow whole or may open caps and sprinkle pellets on 1 tablespoon applesauce and take immediately. May open caps and mix granules in 50mL of water and give via NG tube; flush tube with more water. Susp: mix contents of packet in 15mL of water, leave 2–3 minutes, then drink within 30 minutes. May give via NG or gastric tube (see literature). Triple therapy: esomeprazole 40mg once daily + amoxicillin 1g twice daily + clarithromycin 500mg twice daily; all for 10 days. EE: 20 or 40mg once daily for 4–8 weeks, may continue 4–8 more weeks. Maintenance of healing of EE: 20mg once daily. Symptomatic GERD: 20mg once daily for 4 weeks, may continue 4 more weeks. NSAID-associated ulcer risk reduction: 20mg or 40mg once daily for up to 6 months. Hypersecretory conditions: initially 40mg twice daily, adjust if needed; doses up to 240mg daily have been used. Severe hepatic impairment: max 20mg/day.
Children's dosing for NEXIUM
<1yr: not recommended. GERD: 1–11yrs: <20kg: 10mg; ≥20kg: 10 or 20mg; 12–17yrs: 20 or 40mg. For all: give once daily for up to 8 weeks.
      
Also:
NEXIUM for ORAL SUSPENSION
NEXIUM IV
      
Warnings/Precautions for NEXIUM
Long term and multiple daily dose therapy: increased risk of osteoporosis-related fractures. Pregnancy (Cat.B). Nursing mothers: not recommended.
Interactions for NEXIUM
Concomitant atazanavir, nelfinavir: not recommended. May potentiate saquinavir; monitor and consider reducing saquinavir dose. May alter absorption of gastric pH-dependent drugs (eg, ketoconazole, iron salts, digoxin). May affect drugs metabolized by CYP2C19. Monitor warfarin. May give antacids concomitantly.
Adverse Reactions for NEXIUM
Headache, diarrhea, abdominal pain, nausea, flatulence, constipation, dry mouth, inj site reactions; rare: rash, allergic reactions.
Notes for NEXIUM
See Biaxin for more information on clarithromycin. See Amoxil for more information on amoxicillin.

How is NEXIUM supplied?
Caps—30, 90, 1000; Susp—30 packets/box; IV soln (single-use vial)—10

近日，第一制药三共和阿斯利康公司宣布，日本劳动厚生省已批准阿斯利康生产和销售质子泵抑制剂耐信胶囊（埃索美拉唑镁，10mg和20mg）。
耐信胶囊获批准的适应证为用于预防接受非甾体抗炎药（NSAIDs）治疗的患者胃溃疡和十二指肠球部溃疡的复发。
耐信胶囊的有效成分埃索美拉唑镁是奥美拉唑（Omepral）的两种同分异构体之一，Omepral的活性物质。埃索美拉唑可选择性抑制H+/K+-三磷酸腺苷酶即酸泵的活性，可抑制胃酸分泌的最后步骤，从而有效控制酸相关性疾病。
Related Disease:
Duodenal ulcers {DU}
Erosive esophagitis
GERD {GERD}
Hypersecretory conditions~Zollinger-Ellison syndrome
Ulcers, duodenal
Ulcers, gastric

完速说明书
www1.astrazeneca-us.com/pi/Nexium.pdf
Product Description
Gastrozole Capsule Each capsule contains:- Enteric-Coated Pallets of Esomeprazole as (Magnesium Trihydrate) 20 mg 2x7’s Gastrozole Capsule Each capsule contains:- Enteric-Coated Pallets of Esomeprazole (Magnesium Trihydrate) 40 mg 2x7’s