【中文品名】阿莫西林+克拉霉素+兰索拉唑
【药效类别】抗消化道溃疡药>复方
【通用药名】AMOXICILLIN+CLARITHROMYCIN+LANSOPRAZOLE
【别　　名】Prevpac，Amoxicillin/Clarithromycin/Lansoprazole
【收录药典】
【开发单位】TAP PHARM
【首次上市】
【性　　状】由阿莫西林、克拉霉素和兰索拉唑组成的复方药物。
【用　　途】用于由幽门螺旋杆菌引起的胃肠道溃疡。
【生产厂家】Abbott

PrevPac（兰索拉唑/阿莫西林/克拉霉素）是一种方便的, 含每日多种药物剂量包, 以消除幽门螺杆菌和减少十二指肠球部溃疡复发危险的治疗药物。每个剂量包包含了一天三种不同的处方药。减酸药物兰索拉唑缓释胶囊(lansoprazole)和两种抗生素称为TRIMOX（阿莫西林胶囊，USP）和BIAXIN（克拉霉素片）。
PrevPac三联药物用于消除幽门螺旋杆菌，减少十二指肠溃疡复发的风险。
当天上午，服用一粒30毫克的兰索拉唑缓释胶囊(lansoprazole)，两粒500毫克阿莫西林胶囊(TRIMOX)，一粒500毫克的克拉霉素片(BIAXIN)。到了晚上，重复服用相同的药品和剂量。继续服用10或14天每日两次的治疗。
PrevPac三联药物通常需要大约两个星期清除幽门螺旋杆菌。即使感觉好转，也应该按医生指示服药。如果停止服用药物过早，可能无法完全消除溃疡的幽门螺旋杆菌。

Prevpac
Generic name: Amoxicillin, clarithromycin, and lansoprazole
What is Prevpac?
Prevpac is a prepackaged combination of drugs designed to treat duodenal ulcers caused by Helicobacter pylori bacteria, the most common cause of ulcers. Prevpac is made up of 3 medications: amoxicillin and clarithromycin (Biaxin) are the antibiotic components and lansoprazole (Prevacid) is a proton-pump inhibitor that reduces the production of gastric acid.
What is the most important information I should know about Prevpac?
Take Prevpac exactly as prescribed and finish your entire course of therapy. If you stop too soon, the ulcer may not heal completely and your symptoms may return.
Serious and occasionally fatal allergic reactions have occurred in people taking antibiotics similar to those in Prevpac. Seek emergency medical treatment if you develop hives, swelling, itching, fainting, breathing difficulties, or chest pain. Also, if you develop severe diarrhea while taking Prevpac, call your doctor.
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Who should not take Prevpac?
Prevpac therapy is not recommended if you have severe kidney disease. Use Prevpac with caution if you are over 65 years old.
Do not take Prevpac if you've ever had an allergic reaction to antibiotics such as amoxicillin, clarithromycin, erythromycin, or penicillin. Also, avoid Prevpac if you've had a reaction to any cephalosporin-type antibiotic.
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What should I tell my doctor before I take the first dose of Prevpac?
Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Prevpac. Also, talk to your doctor about your complete medical history, especially if you have kidney or liver disease.
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What is the usual dosage?
The information below is based on the dosage guidelines your doctor uses.
Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: The recommended dosage is 1 capsule of lansoprazole (Prevacid), 2 capsules of amoxicillin, and 1 tablet of clarithromycin (Biaxin) taken together twice a day (morning and evening) for 10 or 14 days.
How should I take Prevpac?
Each pack contains a full day's supply of medication, consisting of two 30-milligram (mg) capsules of lansoprazole (Prevacid), four 500-mg capsules of amoxicillin, and two 500-mg tablets of clarithromycin(Biaxin). Take half the supply in the morning and the remainder at night.
Prevpac can be taken with or without food. Swallow each pill whole; do not crush or chew.
What should I avoid while taking Prevpac?
There are no restrictions on food, beverages, or activity while you are taking the medications contained in Prevpac, unless your doctor directs otherwise.
What are possible food and drug interactions associated with Prevpac?
If Prevpac is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Prevpac with drugs used to treat HIV infection as well as the following: alfentanil, alprazolam, ampicillin, antiarrhythmics (such as quinidine and disopyramide), astemizole, blood thinners, bromocriptine, carbamazepine, cholesterol-lowering drugs (such as lovastatin and simvastatin), cilostazol, cisapride, cyclosporine, digoxin, disopyramide, ergotamine-based drugs for migraine, ketoconazole, hexobarbital, iron supplements, methylprednisolone, midazolam, probenecid, phenytoin, pimozide, rifabutin, sildenafil, sucralfate, tacrolimus, terfenadine, theophylline, triazolam, valproic acid

What are the possible side effects of Prevpac?
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: diarrhea, headache, taste disturbances
Can I receive Prevpac if I am pregnant or breastfeeding?
The effects of Prevpac during pregnancy and breastfeeding are unknown.
Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Prevpac?
Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at the same time.
How should I store Prevpac?
Store Prevpac at room temperature, away from light and moisture.
How To Use
HOW TO USE THIS MEDICATION: Take by mouth exactly as directed by your doctor, usually one dose (which contains four pills) twice daily before a meal.
Swallow each pill whole.
Do not divide, crush or chew.
Each packet contains both the morning and evening dose of your medicines (one day supply).
Consult your pharmacist or doctor for instructions on the proper use of this product.
If also taking sucralfate, this product should be taken at least 30 minutes before the sucralfate dose.
Finish your entire treatment even if your symptoms improve.
Side Effects
Headache, dizziness and abnormal taste may occur.
If these effects persist or worsen, notify your doctor promptly.
Report diarrhea promptly.
Unlikely but report promptly nausea, stomach pain, or dark or bloody stools.
Very unlikely but report promptly chest pain, sudden weakness, vision changes, unusually fast or irregular heart beats, vomiting, mouth sores, tongue discoloration, muscle pain, persistent sore throat with fever, unusual bruising or bleeding, yellowing eyes or skin, mood/mental changes, increased thirst or hunger, or change in amount or color of urine.
In the unlikely event you have an allergic reaction to this drug, seek medical attention immediately.
Symptoms of an allergic reaction include rash, itching, swelling, fainting or trouble breathing.
If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
Before using this drug, tell your doctor your entire medical history, including any allergies (especially drug allergies), liver or kidney disease, asthma or other lung disease, high blood pressure, or diabetes.
Limit alcohol intake, as it may worsen certain side effects of this medication.
Since this drug may cause dizziness, use extreme caution if operating machinery or performing hazardous tasks (e.g., driving).
This medication should be used only when clearly needed during pregnancy.
Discuss the risks and benefits with your doctor.
The amoxicillin in this product is excreted into breast milk.
Because of the potential risk to the infant, breast-feeding while using this drug is not recommended.
Consult your doctor before breast-feeding.
Elderly patients may be more sensitive to the effects of this drug, therefore caution is advised.
Missed Dose
If you miss a dose, take it as soon as you remember.
If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
Do not double the dose to catch up.
Drug Interactions
Tell your doctor of all nonprescription and prescription medication you may use, especially cisapride, pimozide, cyclosporine, tacrolimus, certain antihistamines (e.g., terfenadine, astemizole), theophylline, "blood thinners" such as warfarin, digoxin and other heart medications(e.g., disopyramide), zidovudine, certain drugs for high cholesterol(e.g., lovastatin), drugs for blood pressure (e.g., propranolol), drugs for diabetes (e.g., glyburide), bromocriptine, anti-seizure medications (e.g., carbamazepine, phenytoin, valproate), drugs for migraines (e.g., dihydroergotamine, ergotamine), drugs for sleep (e.g., triazolam), barbiturates (e.g., hexobarbital) and certain narcotic pain relievers (e.g., alfentanil).
Sucralfate may reduce the absorption of the lansoprazole in this product.
Lansoprazole may decrease the absorption of iron supplements (e.g., ferrous sulfate), digoxin and certain antifungals (e.g., ketoconazole, itraconazole).
Consult your pharmacist or doctor.
This drug may interfere with the effectiveness of birth control pills.
Discuss using other methods of birth control with your doctor.
Do not start or stop any medicine without doctor or pharmacist approval.