【中文品名】美卡舍明
【药效类别】抗糖尿病药，抗侏儒症药
【通用药名】MECASERMIN
【别　　名】FK-780, IGF-1, Somazon, Somatomedin-1, Somatomedin-C
【化学名称】 Insulin-like growth factor I
【CA登记号】[67763-96-6]
【结 构 式】
【分 子 式】CHNOPS·
【分 子 量】
【收录药典】
【开发单位】藤泽
【首次上市】1995年，日本
【性　　状】
【用　　途】
　　一种重组Somatomedin-1，用于胰岛素抗性糖尿病和抗生长激素的侏儒症。还可用于骨疾病，如骨质疏松症、骨折、类风湿性关节炎和治疗溃疡、烧伤和创伤。

Self-injection
Revised: 2/2012
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name : Somazon 10mg for Injection
　Active ingredient: Mecasermin (genetical recombination)
　Dosage form: injectable preparation
　Print on wrapping:
Effects of this medicine
This medicine acts on receptors in the muscle, fat cells, liver, etc. to accelerate glucose transport into cells, thus reducing the blood sugar level. It is usually used for the treatment of hyperglycaemia, hyperinsulinaemia, acanthosis nigricans, hypertrichosis, etc. due to insulin receptor abnormality, etc.
The medicine also acts on receptors on chondrocytes to expand bones, thus promoting growth. It is usually used for the treatment of failure to thrive due to isolated growth hormone deficiency type 1A or Laron dwarfism.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you have a malignant tumor.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•General dosage regimen:
To improve hyperglycaemia, hyperinsulinaemia, acanthosis nigricans and hypertrichosis, inject 0.1 to 0.4mg/kg subcutaneously at a time, once or twice daily, before meal/s. Inject before breakfast if it is administered once a day, and inject before breakfast and supper if it is administered twice a day.
To improve failure to thrive, inject 0.05 to 0.2mg/kg at a time subcutaneously, once or twice daily, before meal/s. Administer before breakfast if it is administered once a day, and inject before breakfast and supper if it is administered twice a day. One vial contains 10mg of this medicine. Strictly follow the instructions of your doctor/pharmacist.
•When you use the medicine, add the accompanying saline diluent and rotate the vial gently with a circular motion to dissolve the medicine. Do not shake the vial vigorously. Use the medicine as soon as possible once it is dissolved.
•The injection site should be changed in turn, such as the arms, thigh, abdomen, hips, etc. Do not inject the medicine in the same site repeatedly.
•Consult your doctor or pharmacist if you have missed an injection. DO NOT inject double doses to make up for the missed dose.
•If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
•Do not stop injecting the medicine on your own judgment without the instructions of your doctor.
Precautions while taking this medicine
•You may experience hypoglycaemia. Share the information with your family about that taking this medicine may cause hypoglycaemia. Refrain from driving a car, working at heights, operating dangerous machinery, etc. Take something that contains sugar, such as plain sugar or juice, if you have signs or symptoms of hypoglycaemia such as dizziness, light-headedness, etc.
 
Possible adverse effects of this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: hypoglycaemia (sweating, palpitations, headache, etc.), queasiness, pallor, urticaria, injection site redness, diabetic retinopathy, oedema, dizziness, bad feeling, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of infants and children. Store away from light, heat and humidity and keep it at temperatures below 5℃.
•Discard the remainder. Do not store it. Consult with your dispensing pharmacy when you discard the medicine.