Generic Name and Formulations:
Diltiazem HCl 120mg, 180mg, 240mg, 300mg, 360mg; ext-rel caps.
Company:
AbbVie
Indications for CARDIZEM CD:
Vasospastic and chronic stable angina.
Adult Dose for CARDIZEM CD:
Initially 120–180mg once daily. Titrate over 7–14 days; usual max 480mg once daily.
Children's Dose for CARDIZEM CD:
Not recommended.
See Also:
CARDIZEM
CARDIZEM LA
Pharmacological Class:
Calcium channel blocker (benzothiazepine).
Contraindications:
Sick sinus syndrome, 2nd- or 3rd-degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.
Warnings/Precautions:
Heart failure. Impaired renal or hepatic function (monitor). Obstructive hypertrophic cardiomyopathy. Discontinue if persistent rash occurs. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions:
Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, cyclosporine, carbamazepine, lovastatin, simvastatin (consider dose adjustment; monitor). Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers (eg, rifampin). Anesthetics may potentiate cardiac depression.
Adverse Reactions:
Edema, headache, fatigue, dizziness, asthenia, 1st-degree AV block, bradycardia, flushing, nausea, rash (may be serious); rare: CHF, hypotension, liver abnormalities.
How Supplied:
LA tabs—30, 90; CD 120mg, 180mg, 240mg, 300mg—30, 90; CD 360mg—90; Tabs 30mg, 60mg—100, 500; 90mg, 120mg—100