INTRALIPID 20% IV-肠道内营养剂
通用名：脂肪乳注射液
英文名：Fat Emulsion Injection, Intralipid
拼音名：Zhifangru Zhusheye
药品类别 营养治疗药
【别名】英脱利匹特、乳化脂肪。
【作用与用途】
本品是供静脉输注用的灭菌的脂肪乳剂，含有注射用大豆油和注射用卵磷脂，其中大约60％的脂肪酸是必需脂肪酸，其粒径大小和生物特性与天然乳糜微粒相似。本品是静脉营养的组成部份之一，为机体提供能量和必需脂肪酸，用于胃肠外营养补充能量及必需脂肪酸，预防和治疗人体必需脂肪酸缺乏症，也为经口服途径不能维持和恢复正常必需脂肪酸水平的病人提供必需脂肪酸。提供热量和脂肪酸。用于消耗性疾病、烧伤、创伤、手术后补充营养。
【剂量与用法】
成人：静脉滴注，按脂肪量计，每天最大推荐剂量为3g(甘油三酯)/kg。本品提供的能量可占总能量的70％。10％、20％脂肪乳注射液500ml的输注时间不少于5小时；30％脂肪乳注射液250ml的输注时间不少于4小时。新生儿和婴儿：10％、20％脂肪乳注射液每天使用剂量为0.5～4g(甘油三酯)／kg，输注速度不超过0.17g／kg／小时。每天最大用量不应超过4g／kg。只有在密切监测血清甘油三酯、肝功能、氧饱和度等指标的情况下输注剂量才可逐渐增加至每天4g／kg。早产儿及低体重新生儿，最好是24小时连续输注，开始时每天剂量为0.5～1g／kg，以后逐渐增加到每天2g／kg。本品可单独输注或用于配制含葡萄糖、脂肪、氨基酸、电解质、维生素和微量元素等的“全合一”营养混合液。只有在可配伍性得到保证的前提下，才能将其它药品加入本品内。也可与葡萄糖注射液或氨基酸注射液通过Y型管道混合后输入体内。该法既适用于中心静脉也适用于外周静脉。在无菌操作条件下，下列药品可加入本品内：
1．维他利匹特(成人)／维他利匹特(儿童)；
2．水乐维他(有关配制方法详见水乐维他说明书)。
【不良反应】
过敏反应：发热、体温升高、发冷、畏寒、过敏反应[4136]、高过敏反应(过敏反应[1545、1553]、皮疹、荨麻疹、过敏性休克[1547])，呼吸影响(如呼吸急促、困难)以及循环影响(如高血压、低血压)。血液系统：
1.即刻和早期副作用：溶血、网状红细胞增多
2.迟发副作用：长期输注本品，婴儿可能发生血小板减少。另外，长期静脉营养时即使不用本品也会有短暂的肝功能指标的异常。偶可发生静脉炎，血管痛及出血倾向。
3．病人脂肪廓清能力减退时，尽管输注速度正常仍可能导致脂肪超载综合征。脂肪超载综合征偶尔也可发生于肾功能障碍和感染患者。脂肪超载综合征表现为：高脂血症、发热、脂肪浸润、脏器功能紊乱等，但一般只要停止输注，上述症状即可消退。消化系统：恶心、呕吐、腹痛、肝功能损害。神经系统：神经系反应[1546](头痛、疲倦、谵语，抓空动作，自行要求起立行走、浅昏迷)。致中枢神经系统不良反应[904]：表现为兴奋、躁动、谵语,自觉要求起立行走.立即停药后症状逐渐减轻,而后出现浅度昏迷。其他：阴茎异常勃起。
【注意事项】
休克和血栓患者禁用。本品慎用于脂肪代谢功能减退的患者，如肝、肾功能不全，糖尿病酮中毒、胰腺炎、甲状腺机能低下(伴有高脂血症)以及败血症患者慎用。这些患者输注本品时，应密切观察血清甘油三酯浓度，连续使用一周以上的患者，应检查患者的脂肪廓清能力。对大豆蛋白过敏者慎用本品，使用前必须做过敏试验。
新生儿和未成熟儿伴有高胆红素血症或可疑肺动脉高压者应谨慎使用本品。新生儿，特别是未成熟儿，长期使用本品必须监测血小板数目、肝功能试验和血清甘油三酯浓度。因缺乏30％脂肪乳注射液用于婴儿和儿童的经验，所以暂不推荐给婴儿和儿童使用。采血时，如本品还没有从血流中完全清除，则将干扰其它实验室检测项目(如胆红素、乳酸脱氢酶、氧饱和度、血红蛋白等)。绝大多数病人在本品输注后5～6小时，即可被完全清除。孕妇：已有报道表明妊娠妇女使用10％和20％脂肪乳注射液是安全和成功的。理论上30％与10％和20％脂肪乳注射液一样，也能用于妊娠妇女，但尚缺乏动物生殖研究的证据。使用本品一周以上必须做脂肪廓清试验。具体操作如下：输注前采血样，离心，如果血浆呈乳状，则原定的输注计划应延期实施(此法不适用于高脂血症的患者)；当发现病人脂肪廓清能力降低时，最好再查血清甘油三酯。对于婴儿和儿童，监测脂肪廓请能力的最可靠的办法是定期测定血清甘油三酯水平。本品开瓶后一次未使用完的药液应予丢弃，不得再次使用。
【制剂规格】
注射液：250ml:25g、500ml:50g、100ml:20g、250ml:50g、500ml:100g。
【贮藏】
25℃以下，不得冰冻。有效期2年。
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Indications: lipid infusion for parenteral nutrition As a source of energy and essential fatty acids for patients requiring IV nutrition.
Pre- and postoperative nutritional disturbances in which a large supply of energy is necessary or desirable eg, in order to improve the nitrogen balance. Nutritional disorders or disturbances of nitrogen balance due to inadequate or failing intestinal absorption caused by tumours in the gastrointestinal tract, acute or chronic intestinal diseases (peritonitis, ulcerative colitis, terminal ileitis) and others. Burns, in extensive burns, every additional supply of energy is of value as a means of reducing the frequently excessive nitrogen losses.
A large supply of energy also improves the utilization of orally ingested protein as well as of infused Vamin. IV administered fat is also indicated in patients in whom oral nutrition is inadequate.
Prolonged unconsciousness eg, following cranial traumata or poisoning in cases where tube feeding is inappropriate or impossible. Impaired renal function, in which condition an adequate supply of energy is essential to reduce protein breakdown. Cachexia.
Emulsions of fractionated soya oil containing 10, 20, or 30% are given by slow intravenous infusion as part of total parenteral nutrition regimens (), usually with amino acid and carbohydrate solutions. The solutions and emulsions may be given at separate sites, at the same site through a Y-connector, or combined in one admixture. Fat emulsions provide a high energy intake in a relatively small volume.
They may also be used to prevent or correct essential fatty acid deficiency. When used as a calorie source the dose of the emulsion is determined by the energy requirements and clinical status of the patient; the amount of total carbohydrate, generally, should not comprise more than 60% of patients’ total calorie intake. For the prevention and correction of fatty acid deficiency about 5 to 10% of total calorific intake should be as an intravenous fat emulsion.
The composition and dosage recommendations of commercial preparations do differ slightly but they should be started slowly. Suggested initial rates for the 10% and 20% products are 1 mL/minute and 0.5 mL/minute respectively for 15 to 30 minutes.
The rate may then be increased and up to about 500 mL (or 10 mL/kg) of 10% or 250 mL (or 5 mL/kg) of 20% emulsion may be given on the first day.
The total daily dosage may then be increased gradually on subsequent days; suggested daily dose ranges are 500 to 1500 mL of a 10% or 500 to 1000 mL of a 20% emulsion and suggested rates of infusion are 500 mL of a 10% emulsion over a period of not less than 3 hours, and 500 mL of a 20% emulsion over not less than 5 hours.
Where a 30% emulsion is used, a dose of 333 mL or about 4.75 mL/kg has been recommended, given over 5 hours or more; the first dose should not exceed 3 mL/kg. Soya oil also has emollient properties and is used as a bath additive in the treatment of dry skin conditions. Supply of energy & essential fatty acids as IV solution
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产地国家: 美国
原产地英文商品名:
INTRALIPID 20% IV FAT EMULSION 1000ML 6 EACH CASE
原产地英文药品名:
Soybean Oil, Fat Emulsions
中文参考商品译名:
INTRALIPID注射液 20% 1000毫升/瓶 6瓶/盒
中文参考药品译名:
脂肪乳注射液
生产厂家英文名:
Baxter & Fresenius Kabi
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产地国家: 美国
原产地英文商品名:
INTRALIPID 20% IV FAT EMULSION 500ML 12EACH CASE
原产地英文药品名:
Soybean Oil, Fat Emulsions
中文参考商品译名:
INTRALIPID注射液 20% 500毫升/瓶 12瓶/盒
中文参考药品译名:
脂肪乳注射液
生产厂家英文名:
Baxter & Fresenius Kabi
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产地国家: 美国
原产地英文商品名:
INTRALIPID 20% IV FAT EMULSION 250ML 10EACH CASE
原产地英文药品名:
Soybean Oil, Fat Emulsions
中文参考商品译名:
INTRALIPID注射液 20% 250毫升/瓶 10瓶/盒
中文参考药品译名:
脂肪乳注射液
生产厂家英文名:
Baxter & Fresenius Kabi
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注：以下产品是韩国产品，购买时以咨询为准！
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인트라리피드 10%주 (Intralipid 10% Inj.)
주성분 및 함량
이 약 100ml 중
정제대두유(EP) 10.0g
성상
유백색의 유탁액이 수액용 플라스틱 용기 든 주사제
효능·효과
비경구 영양공급 처방의 일부로서 에너지 및 필수 지방산의 보급
용량·용법
1) 성인 : 일반적으로 체중 kg당 정제대두유로서 1일 2 g(10%는 20 mL) 이내로 한다. 투여시간은 3시간 이상에 걸쳐 점적 정맥주사한다.
첫째날 처음 주사에 한하여 체중 kg당 1 g 이내로 투여한다.
2) 환자의 생리학적 물질대사 상태를 고려하여 필수 지방산과 칼로리의 요구량에 맞게 점적 정맥주사한다.
사용상 주의 사항
* 자세한 내용은 로그인을 하셔야 확인 하실 수 있습니다.
저장방법
밀봉용기, 25℃ 이하 실온 보관
사용기간
제조일로부터 24개월
포장단위
500ml/백
