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英文药名：NAUZELIN Suppository（Domperidone）
中文药名：多潘立酮坐剤
生产厂家：协和发酵麒麟
类别名称
消化道机能改善剂
欧文商標名
NAUZELIN Suppository
一般名
ドンペリドン Domperidone
化学名
5-Chloro-1-｛1-[3-（2-oxo-2,3-dihydro-1H-benzoimidazol-1-yl）propyl]piperidin-4-yl｝-1,3-dihydro-2H-benzoimidazol-2-one
分子式
C22H24ClN5O2 = 425.91
化学構造式
性状
白结晶粉末细黄或粉末（而不是臭，微苦）。
可溶性
易溶于乙酸（100），和微溶于甲醇或乙醇（99.5），极微溶于2-丙醇，和几乎不溶于水。
熔点
约243℃（分解）
分配系数
logP'OCT=3.20
[测量方法：摇瓶方法，正辛醇/pH7.4缓冲溶液]
适应证
成人（坐剤60 ）
下列疾病和胃肠道症状药物管理局（恶心，呕吐，食欲不振，腹胀，上腹部不适，胃灼热）的时间
○胃，十二指肠手术
○执政期间抗肿瘤药
孩子（坐剤10 坐剤30）
下列疾病和胃肠道症状药物管理局（恶心，呕吐，食欲不振，腹胀，腹痛）的时间
○周期性呕吐综合征，小儿腹泻，上呼吸道感染
○执政期间抗肿瘤药
用法用量
直肠给药
成人：每栓60mg
○每次在直肠用60毫克，每天两次。此外，年龄，将根据症状调整。
孩子（每栓：坐剤10 坐剤30）
在小于3岁的情况下，使用一次10mg，每日2-3次。
超过3岁，给药一次30毫克，每天2-3次。此外，将根据年龄，体重和症状调整。
包装规格：
坐剤10：20個（5個×4）
坐剤30：20個（5個×4）
坐剤60：20個（5個×4）
制造厂商
协和发酵麒麟有限公司
NAUZELIN Suppository（Domperidone）
NAUZELIN Suppository 10（ナウゼリン坐剤10）
Brand name : NAUZELIN Suppository 10
Active ingredient: Domperidone
Dosage form: white to yellowish white suppository, maximum diameter: approx. 8 mm, length: approx. 25 mm
Print on wrapping: KH308 10mg ナウゼリン
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NAUZELIN Suppository 30（ナウゼリン坐剤30）
Brand name : NAUZELIN Suppository 30
Active ingredient: Domperidone
Dosage form: white to yellowish white suppository, maximum diameter: approx. 8 mm, length: approx. 25 mm
Print on wrapping: KH309 30mg ナウゼリン
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NAUZELIN Suppository 60（ナウゼリン坐剤60）
Brand name : NAUZELIN Suppository 60
Active ingredient: Domperidone
Dosage form: white to yellowish white suppository, maximum diameter: approx. 10 mm, length: approx. 27 mm
Print on wrapping: KH311 60mg ナウゼリン
Effects of this medicine
This medicine suppresses activities of dopamine in the stomach and duodenum to improve gastrointestinal motility, and acts on CTZ (chemoreceptor trigger zone) involved in causing nausea to suppress nausea.
It is usually used to treat nausea in postoperative periods of the gastric and duodenal surgery.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have: gastrointestinal bleeding, mechanical ileus, gastrointestinal perforation, prolactinoma, hepatic disorder or renal disorder.
•If you are pregnant, possible pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adult, insert 1 suppository (60 mg of the active ingredient) into the rectum at a time, twice daily. The dosage may be adjusted according to the age or symptoms. Strictly follow the instructions.
•If you miss a dose, use a dose as soon as possible when the symptom of nausea is severe. Wait more than 7 hours to use a next dose. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.You should never use two doses at one time.
•If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop using this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may cause sleepiness and dizziness. Take care in driving a car or engaging in dangerous activities.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include diarrhea, defecation desire, anal discomfort, strange sensation when suppository is inserted, hepatic dysfunction and gynecomastia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•dizziness, orthostatic dizziness, cold sweat, facial pallor [shock]
•breathing difficulty, hives, swelling around eyes and mouth [anaphylactoid symptoms]
•tremor of limbs, muscle stiffness, twist or cramp in neck, upward rotation of eyes [extrapyramidal symptoms]
•decreased consciousness, sudden muscle contraction [consciousness disorder, convulsion]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
Kyowa Hakko Kirin Co.,LtdExternal
Revised: 7/2012
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/2399714J1026_1_10/
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