英文药名：ACTIVACIN （Alteplase[genetical recombination]for Injection）

中文药名：阿替普酶注射剂

生产厂家：协和发酵麒麟
药品简介
一般的名称
阿替普酶（重组）静脉
本产品为527个氨基酸组成的糖蛋白。
通用名称
阿替普酶（重组）
俗名
rt-PA组
分子量
约64,000
性状
无色透明液体（阿替普酶股）
剂量、疗效和用法
*功能障碍的改善与缺血性脑血管病急性期相关（起病4.5小时后）
通常，成人静脉给药（0.6mg/kg）34.8万国际单位（遗传学重组）每公斤体重阿替普酶。然而，最大剂量达（60毫克）348010000国际单位。总金额（1〜2分钟）的10％推注，给药的给药一小时休息紧随其后。
此外，尽快做药物的起效给药后。
溶解在溶液中根据需要随附的稀释与摩根生理盐水。
冠状动脉血栓的急性心肌梗死（在发病后6小时）溶解
通常情况下，静脉给药（为0.5mg/kg〜0.75mg/kg）29〜43.5万万国际单位（遗传学重组）每公斤体重阿替普酶的成年人。的总量（1〜2分钟）的快速给药10％，余给药一小时，然后休息。
 此外，药物的起效给药后。
溶解在溶液中根据需要随附的稀释与摩根生理盐水。
包装
1. アクチバシン注600万：1瓶（溶解液、溶解液注入針添付）
2. アクチバシン注1200万：1瓶（溶解液、溶解液注入針添付）
3. アクチバシン注2400万：1瓶（溶解液、溶解液注入針添付）

製造販売元
协和发酵麒麟
注：使用时参照原文资料[附件]： http://www.info.pmda.go.jp/go/pack/3959402D1027_1_20/3959402D1027_1_20?view=body
Brand name : ACTIVACIN for Injection 6 million [acute phase of ischemic cerebrovascular disorder]
　Active ingredient: Alteplase(genetical recombination)
　Dosage form: injection
　Print on wrapping: 
Effects of this medicine
This medicine dissolves thrombus (blood clots) through specific adsorption to thrombus formed in blood vessels.
It is usually used for improvement of dysfunction in the acute phase of ischemic cerebrovascular disorder (movement problem such as paralysis or numbness of limb due to reduced blood flow caused by a thrombus in the brain) within the first 4.5 hours of onset.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you are bleeding (intracranial bleeding, gastrointestinal bleeding, urinary tract bleeding, retroperitoneal bleeding, hemoptysis), suspected of having subarachnoid hemorrhage, at risk of cerebral hemorrhage (high blood pressure, high blood glucose, history of intracranial bleeding, bleeding diathesis [intracranial tumor, arteriovenous malformation, aneurysm], cerebral infarction within 3 months, intracranial or spinal surgery/injury within 3 months) or at risk of bleeding (gastrointestinal bleeding or urinary tract bleeding within 21 days, major surgery within 14 days, reduced blood coagulation).
If you have liver disorder, acute pancreatitis, low blood glucose level, history of convulsive seizure after ischemic cerebrovascular disorder, chest pain or back pain.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, this medicine is administered intravenously by rapid injection for 1-2 minutes, then the remainder is administered over 1 hour.
•You will undergo computed tomography (CT) or nuclear magnetic resonance imaging (MRI) of the head before receiving this medicine. You may also undergo chest X-ray.
Precautions while taking this medicine
•Use of this medicine may lead to serious bleeding such as cerebral hemorrhage. Blood pressure measurements and blood tests are thus performed on a frequent basis during and after use of this medicine to discover any bleeding as early as possible.
•Many individuals who use this medicine have heart disorders. Tests including electrocardiography are thus performed continuously during or after use of this medicine.
Possible adverse effects of this medicine
The most commonly reported adverse reactions include hemorrhagic cerebral infarction, subcutaneous bleeding, cerebral hemorrhage, gastrointestinal bleeding, headache, injection site bleeding, oral hemorrhage and hematuria. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•paralysis of unilateral limb, black stool, bloody phlegm[serious bleeding (cerebral hemorrhage, gastrointestinal bleeding, pulmonary hemorrhage, retroperitoneal bleeding)]
•headache, paralysis of unilateral limb, impaired consciousness[hemorrhagic cerebral infarction, cerebral infarction]
•cold sweats, difficult to breathe, hives[shock, anaphylactoid symptoms]
•general malaise, difficult to breathe, shortness of breath [heart rupture, cardiac tamponade]
•dizziness, palpitation, chest pain[serious arrhythmia (ventricular fibrillation, ventricular tachycardia)]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.