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英文药名：Persantin Tablets（Dipyridamole）
中文药名：双嘧达莫片
生产厂家：勃林格殷格翰有限公司
给药说明
本品为较强的冠状血管扩张药，能显著持久地增加冠脉流量，增加心肌供氧量。但由于主要扩张冠状小动脉即阻力血管，缺血区血流量不增加甚至减少，故对心绞痛的疗效不确切。而长期应用可促进侧支循环形成并具有抗血小板聚集作用，对冠心病的防治有益。
商標名
Persantin Tablets
一般名
ジピリダモール（JAN）
Dipyridamole（JAN）
化学名
2,2´,2´´,2´´´-{[4,8-Di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo}tetraethanol
化学構造式
分子式
C24H40N8O4
分子量
504.63
性状
·结晶性粉末或黄色，无臭晶体，味微苦。
·它是易溶于氯仿中，微溶于乙醇或甲醇（99.5），并在乙醚或几乎不溶于水。
熔点
165〜169℃
适应症
缺血性心脏疾病，充血性心脏衰竭和其他，（除了急性期）心绞痛，心肌梗塞
用法用量
口服：1日3次，每次25毫克。此外，增加或减少取决于患者的年龄和症状。
包装规格
片剂 12.5毫克：
1000片（10片×10），PTP100片（10片×100）的PTP
片剂 25毫克
500片一瓶，2100片（21粒×100）的PTP，1000片（10片×100）的PTP，100片（10片×10）PTP
制造商
勃林格殷格翰日本公司
完整资料附件：http://www.info.pmda.go.jp/go/pack/2171010F1409_1_03/
Persantin Tablets 25mg 12.5mg
Brand name : Persantin Tablets 25mg Tablets 12.5mg
Active ingredient: Dipyridamole
Dosage form: orange-red tablet (diameter: 6.3mm, thickness: 3.3mm)
Printings on wrapping: (Face) Persantin, PE25
(Back) ペルサンチン25mg, 12.5mg， company logo, Boehringer Ingelheim, recycle mark
Effects of this medicine
This medicine improves cardiac function by improving blood flow in the heart through its vasodilator effect.
By concomitant administration with warfarin, this medicine suppresses blood clotting inside the blood vessels after heart valve replacement.
This medicine decreases protein excretion in the urine due to a renal disease.
Before using this medicine, tell your doctor/pharmacist
If you have ever had any unusual or allergic reaction (itch, rash etc.) to any medicines.
If you have hypotension, angina pectoris, myocardial infarction, etc. due to cardiovascular disease.
Make sure your doctor knows if you are already pregnant or are breastfeeding.
If you are using any other prescription or nonprescription (OTC) medicine. (It is important to reduce the risk of drug interactions.)
Dosage regimen (proper use of this medicine)
Your dosage regimen is:(order of your doctor)
General dosage regimen:
[When you take this medicine for improvement of cardiac function]
Usually for adults, one tablet (25mg of dipyridamole) is orally administered three times daily and the dosage may be adjusted according to the disease to be treated, the patient's age and severity of symptoms. Follow your doctor's instructions.
[When you take the medicine for suppression of blood clotting]
Usually for adults, 4 tablets (100mg of dipyridamole) are orally administered three to four times daily and the dosage may be adjusted according to the disease to be treated, the patient's age and severity of symptoms. Follow your doctor's instructions.
[When you take this medicine for reduction in urinary protein]
Usually for adults, 4 tablets (100mg of dipyridamole) are orally administered three times daily and the dosage may be adjusted according to the disease to be treated, the patient's age and severity of symptoms. Follow your doctor's instructions.
Missed dose: If you are ordered to take this medicine on regular schedule and you missed a dose, take as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take a double dose to make up for the missed dose.
Overdose: If you took too much of this medicine, check with your doctor/pharmacist immediately.
Others: Do not stop your medication without the instructions of your doctor.
Precautions while using this medicine
Side effects of this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: headache, nausea, heart pounding, abdominal pain, weakness, malaise, rash.In rare cases, symptoms described below may be the sign of side effects indicated in brackets [ ]. If they occur, stop taking your medicine and check with your doctor immediately.
worsening of chest pain, a sensation of chest pressure, cold sweat, etc. [aggravation of anginal symptoms]
black points and insect-like object(s) seen in the visual field, black stools, headache, etc. [bleeding tendency (hemorrhage of the eye ground, gastrointestinal hemorrhage, intracerebral hemorrhage, etc.)]
subcutaneous bleeding, gum bleeding, nasal bleeding, etc. [decrease in platelets]
sudden attack of breathlessness, wheezing (a whistling noise in breathing), edema in the periphery of the eyes and lips, etc.[hypersensitivity]
Other side effects not listed here may occur. Check with your doctor/pharmacist if you have any worrisome symptom.
Storage and other information
Keep out of the reach of children. Store away from heat and moisture protected from direct sunlight.
Discard unused medicine.
Manufacturer's name : Nippon Boehringer Ingelheim Co., Ltd.
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